Journal of Prosthetic Dentistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 248 - 248
Published: Feb. 21, 2025
Background/Objectives: Rhabdomyolysis, a dangerous breakdown of skeletal muscle, has been reported as an adverse event in those prescribed statin therapy for the treatment hypercholesterolemia. Statin drugs are some most treatments elevated cholesterol levels. The purpose this comparative study was to determine association between used and risk rhabdomyolysis using FDA Adverse Event Reporting System (FAERS) transcriptomic data. Methods: A disproportionality analysis performed compare reference drug (simvastatin) group, with patient age assessed possible confounder. In addition, rule mining utilized both identify other events that frequently presented drug-drug interactions (DDIs). Finally, public data were explored genetic underpinnings highlighting these differences across statins. Results: Rhabdomyolysis is commonly patients treated statins, particularly simvastatin. Simvastatin associated more than 2-fold increased likelihood compared Men twice likely report women regardless treatment, highest observed pravastatin (ROR = 2.30, p < 0.001) atorvastatin 2.03, 0.0001). Several DDIs identified, including furosemide/Lasix, allopurinol clopidogrel/Plavix, pantoprazole, which may elevate through impaired muscle function delayed metabolism. nine myopathic genes identified regulators statin-induced rhabdomyolysis, DYSF, DES, PLEC, CAPN3, SCN4A, TNNT1, SDHA, MYH7, PYGM primary human cells. Conclusions: rhabdomyolysis. pronounced men women. pantoprazole.
Language: Английский
Citations
1
Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41629 - e41629
Published: Jan. 1, 2025
Language: Английский
Citations
0
eFood, Journal Year: 2025, Volume and Issue: 6(1)
Published: Jan. 20, 2025
ABSTRACT Mushrooms have long been an integral part of human culture and health are valued for their nutritional therapeutic properties. Often referred to as a superfood, mushrooms rich in bioactive compounds that provide range benefits including antioxidant, antimicrobial, anticancer, prebiotic, antidiabetic, anti‐inflammatory effects. This review focussed on the diversity mushrooms, emphasizing medicinal significance, explores secondary metabolites with potential applications nutraceuticals pharmaceuticals. It underscores role vital agents developing value‐added products. An overview compounds, such polysaccharides, peptides, proteins, terpenoids, phenolic identified numerous mushroom species. Additionally, addresses advancements fungal biotechnology, particularly use fungi efficient industrial cell factories, influence food quality sustainability. By critically analyzing recent studies, summarizes diverse roles biomolecules pharmaceutical industries highlights significant contribution modern medicine health‐related fields.
Language: Английский
Citations
0
Independent Nurse, Journal Year: 2025, Volume and Issue: 2025(1), P. 11 - 13
Published: Jan. 2, 2025
Mark Greener looks at how fungi have affected the development of life-saving medicines
Language: Английский
Citations
0
Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 16, 2025
Lipoprotein(a) (Lp(a)) serum concentration plays a crucial role as risk factor in cardiovascular diseases and is gaining more attention. Patients with elevated lipoprotein(a) levels are often prescribed statins they also have high concentrations of low-density lipoprotein cholesterol (LDL-C). Statins drugs that successfully decrease LDL-C, but their effectiveness Lp(a) reduction uncertain. The aim this study was to evaluate if statin therapy can affect concentration. A literature search on databases like PubMed, Oxford Academic, ScienceDirect, Embase, Cochrane Library, Scopus, Springer Link conducted from 1 May 10 August 2024 the finding studies concerning effect levels. Only randomised control placebo/comparator arm were included. For calculations, SPSS Statistics software version 29 used. bias for assessed using revised risk-of-bias tool trials. Overall, 43 (13,264 participants arms 11,676 arms) included analysis. mean difference absolute change all equaled 0.22 mg/dL not clinically significant. Egger's regression-based test resulted no (p = 0.404). In conclusion, does significantly Results work suggest people will Lp(a)-associated (CV) by administration.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 221 - 232
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 31, 2025
Language: Английский
Citations
0
Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101958 - 101958
Published: Feb. 10, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 27, 2025
Cholesterol, the most abundant sterol molecule in mammalian organisms, serves not only as a fundamental structural component of cell membranes but also critical regulator cellular signaling and function. Cholesterol-associated proteins can mediate liver injury either directly by influencing cholesterol levels or through non-cholesterol pathways. These pathways, which operate independently cholesterol’s traditional metabolic functions, are regulated specific transcription factors, receptors. Dysregulation cholesterol-associated disrupt homeostasis, leading to injury, disorders, even tumorigenesis. In this article, we explore mechanisms contribute via both classical pathways discuss their potential therapeutic targets for liver-related diseases.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Citations
0