Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke DOI Creative Commons

J Castillo-González,

Lara Buscemi, Pablo Vargas-Rodríguez

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107501 - 107501

Published: Nov. 7, 2024

Ischemic stroke is the result of a permanent or transient occlusion brain artery, leading to irreversible tissue injury and long-term sequelae. Despite ongoing advancements in revascularization techniques, remains second cause death worldwide. A comprehensive understanding complex interconnected mechanisms, along with endogenous mediators that modulate responses essential for development effective interventions. Our study investigates cortistatin, neuropeptide extensively distributed immune central nervous systems, known its immunomodulatory properties. With neuroinflammation peripheral deregulation as key pathological features ischemia, cortistatin emerges promising therapeutic candidate. To this aim, we evaluated potential effect well-established middle cerebral artery (MCAO) preclinical model. findings indicated administration at 24 h post-stroke significantly reduced neurological damage enhanced recovery. Importantly, cortistatin-induced neuroprotection was multitargeted, it modulated glial reactivity astrocytic scar formation, facilitated blood-brain barrier recovery, regulated local systemic dysfunction. Surprisingly, immediate early time points proved be not beneficial even detrimental. These results emphasize importance spatio-temporal dynamics pathology develop innovative strategies appropriate windows. Premature interruption certain neuroinflammatory processes might inadvertently compromise neuroprotective mechanisms. In summary, our highlights novel pleiotropic approach against ischemic stroke, offering new treatment options patients who undergo intervention but unsuccessful

Language: Английский

The antioxidant efficacy of Syagrus coronata fixed oil in reverting rotenone-induced neurotoxicity in mice DOI
Luciclaudio Cassimiro de Amorim, Iverson Conrado Bezerra, Artur José da Silva

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 3, P. 100045 - 100045

Published: April 16, 2024

Language: Английский

Citations

2
Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke DOI Open Access
Julia Castillo-González, Lara Buscemi, Pablo Vargas-Rodríguez

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

Abstract Ischemic stroke is the result of a permanent or transient occlusion brain artery, leading to irreversible tissue injury and long-term sequelae. Despite ongoing advancements in revascularization techniques, remains second cause death worldwide. A comprehensive understanding complex interconnected mechanisms, along with endogenous mediators that modulate responses essential for development effective interventions. Our study investigates cortistatin, neuropeptide extensively distributed immune central nervous systems, known its immunomodulatory properties. With neuroinflammation peripheral deregulation as key pathological features ischemia, cortistatin emerges promising therapeutic candidate. To this aim, we evaluated potential effect well-established middle cerebral artery (MCAO) preclinical model. findings indicate administration at 24 hours post-stroke significantly reduces neurological damage enhances recovery. Importantly, cortistatin-induced neuroprotection was multitargeted, it modulated glial reactivity astrocytic scar formation, facilitated blood-brain barrier recovery, regulated local systemic dysfunction. Surprisingly, immediate early time points proved be not beneficial even detrimental. These results emphasize importance spatio-temporal dynamics pathology develop innovative strategies. Premature interruption certain neuroinflammatory processes might inadvertently compromise neuroprotective mechanisms. In summary, our highlights novel pleiotropic approach against ischemic stroke, offering new treatment options patients whom intervention unsuccessful. Graphical abstract

Language: Английский

Citations

1
Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding DOI Creative Commons

Benjamin A. Benita,

Kyle M. Koss

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Nov. 20, 2024

Uncontrolled and chronic inflammatory states in the Central Nervous System (CNS) are hallmark of neurodegenerative pathology every injury or stroke-related insult. The key mediators these neuroinflammatory glial cells known as microglia, resident immune cell at core event, astroglia, which encapsulate insults proteoglycan-rich scar tissue. Since majority neuroinflammation is exclusively based on responses said glia, their phenotypes have been identified to be an spectrum encompassing developmental, homeostatic, reparative behaviors opposed ability affect devastating death cascades tissue formation. Recently, research groups focused peptide discovery identify phenotypes, find novel mechanisms, mediate re-engineer actions. Peptides retain diverse function proteins but significantly reduce activity dependence delicate 3D structures. Several peptides targeting unique microglia astroglia identified, along with several capable mediating deleterious promoting beneficial outcomes context neuroinflammation. A comprehensive review will provided primary methodologies, including top-down approaches using biomolecules naïve strategies phage libraries.

Language: Английский

Citations

1
Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke DOI Creative Commons

J Castillo-González,

Lara Buscemi, Pablo Vargas-Rodríguez

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107501 - 107501

Published: Nov. 7, 2024

Ischemic stroke is the result of a permanent or transient occlusion brain artery, leading to irreversible tissue injury and long-term sequelae. Despite ongoing advancements in revascularization techniques, remains second cause death worldwide. A comprehensive understanding complex interconnected mechanisms, along with endogenous mediators that modulate responses essential for development effective interventions. Our study investigates cortistatin, neuropeptide extensively distributed immune central nervous systems, known its immunomodulatory properties. With neuroinflammation peripheral deregulation as key pathological features ischemia, cortistatin emerges promising therapeutic candidate. To this aim, we evaluated potential effect well-established middle cerebral artery (MCAO) preclinical model. findings indicated administration at 24 h post-stroke significantly reduced neurological damage enhanced recovery. Importantly, cortistatin-induced neuroprotection was multitargeted, it modulated glial reactivity astrocytic scar formation, facilitated blood-brain barrier recovery, regulated local systemic dysfunction. Surprisingly, immediate early time points proved be not beneficial even detrimental. These results emphasize importance spatio-temporal dynamics pathology develop innovative strategies appropriate windows. Premature interruption certain neuroinflammatory processes might inadvertently compromise neuroprotective mechanisms. In summary, our highlights novel pleiotropic approach against ischemic stroke, offering new treatment options patients who undergo intervention but unsuccessful

Language: Английский

Citations

0