The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 11, 2024

Abstract Background Appropriate iron supplementation is essential for neonatal growth and development. However, there are few reports on the effects of overload immune homeostasis. Thus, aim this study was to investigate nutrition intestinal immunity by administering different levels pigs. Results We found that deficiency resulted in slow Iron led down-regulation jejunum barrier antioxidant marker genes, promoted CD8 + T cell differentiation mesenteric lymph nodes (MLN) pigs, disrupting health. Moreover, altered serum tissue status leading disturbances redox state, affecting host innate adaptive immunity. Conclusions These findings emphasized effect health elucidated importance regulating state This provided valuable insights into regulation function metabolism early life, thus contributing development targeted interventions nutritional strategies optimize neonates.

Language: Английский

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Enhancing food-derived bioactive components delivery: Impact of Fe3+/tannic acid metal-phenolic complexation on structure and in vitro release properties of cellulose nanofibers microgels

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: unknown, P. 111002 - 111002

Published: Dec. 1, 2024

Language: Английский

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Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do not affect number absorbing LRE cells, lower expression endocytic digestion machinery transgene assisted cell isolation single RNA-sequencing, characterize all cells take up dietary protein. We bacteria-sensing metabolic pathways LREs, some secretory types share components with custom-formulated diets, investigated influence diet activity microbiome. Impaired along protein-deficient diet, alters microbial community leads increased abundance bacterial genera have capacity reduce Together, these results reveal diet-dependent reciprocal interactions LREs regulate absorption.

Language: Английский

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Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

Published: Oct. 30, 2024

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do not affect number absorbing LRE cells, lower expression endocytic digestion machinery transgene assisted cell isolation single RNA-sequencing, characterize all cells take up dietary protein. We bacteria-sensing metabolic pathways LREs, some secretory types share components with custom-formulated diets, investigated influence diet activity microbiome. Impaired along protein-deficient diet, alters microbial community leads increased abundance bacterial genera have capacity reduce Together, these results reveal diet-dependent reciprocal interactions LREs regulate absorption.

Language: Английский

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Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 495 - 495

Published: Nov. 17, 2024

The gut dysbiosis present in chronic kidney disease (CKD) has been associated with anemia. Factors such as the accumulation of gut-derived uremic toxins, increased barrier permeability-induced inflammation, and a reduced intestinal production short-chain fatty acids (SCFAs), all changes microbiota composition CKD, may lead to development or worsening anemia renal patients. Understanding addressing these mechanisms related CKD patients can help delay improve its control this population. One approach is avoid reduce use drugs linked phosphate binders, oral iron supplementation, antibiotics, others, unless they are indispensable. Another involves introducing dietary that promote healthier and/or using prebiotics, probiotics, symbiotics setting. These measures increase presence SCFA-producing saccharolytic bacteria proteolytic bacteria, thereby lowering toxins inflammation. By ameliorating CKD-related dysbiosis, strategies also enhance response erythropoiesis-stimulating agents (ESAs) ESA-resistant In review, we have explored relationship between propose feasible solutions, both those already known potential future treatments.

Language: Английский

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