Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns DOI Creative Commons
Bárbara Costa, Maria João Gouveia, Nuno Vale

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1518 - 1518

Published: Dec. 12, 2024

Oxidative stress plays a critical role in various physiological and pathological processes, particularly during pregnancy, where it can significantly affect maternal fetal health. In the context of viral infections, such as those caused by Human Immunodeficiency Virus (HIV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxidative may exacerbate complications disrupting cellular function immune responses. Antiviral drugs, while essential managing these also contribute to stress, potentially impacting both mother developing fetus. Understanding mechanisms which antivirals examination pharmacokinetic changes pregnancy that influence drug metabolism is essential. Some research indicates antiretroviral drugs induce mitochondrial dysfunction other studies suggest their use generally safe. Therefore, concerns about long-term health effects persist. This review delves into complex interplay between antioxidant defenses, antiviral therapies, focusing on strategies mitigate potential damage. By addressing gaps our understanding, we highlight importance balancing efficacy with risks stress. Moreover, advocate for further develop safer, more effective therapeutic approaches pregnancy. dynamics optimizing outcomes fetus infections

Language: Английский

A vaccine against cytomegalovirus: how close are we? DOI Creative Commons
Sallie R. Permar, Mark R. Schleiss,

S. A. Plotkin

et al.

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(1)

Published: Jan. 1, 2025

The pursuit of a vaccine against the human cytomegalovirus (HCMV) has been ongoing for more than 50 years. HCMV is leading infectious cause birth defects, including damage to brain, and common complications in organ transplantation. complex biology made development difficult, but recent meeting sponsored by National Institute Allergy Infectious Diseases September 2023 brought together experts from academia, industry, federal agencies discuss progress field. reviewed status candidate vaccines under study challenges clinical trial design demonstrating efficacy congenital CMV infection or reduction disease following solid transplantation hematopoietic stem cell Discussion revealed that, with numerous that are study, it clear safe effective within reach. Meeting attendees achieved consensus opinion even partially would have major effect on global health consequences infection.

Language: Английский

Citations

1
Elucidating emerging signaling pathways driving endothelial dysfunction in cardiovascular aging DOI

Anna De Bartolo,

Tommaso Angelone, Carmine Rocca

et al.

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107462 - 107462

Published: Jan. 1, 2025

Language: Английский

Citations

1
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis DOI Creative Commons

Sei Kyung Chang,

Yi‐Fang Chuang, Ai‐Hsien Li

et al.

Immunity & Ageing, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 29, 2024

Language: Английский

Citations

4
Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatment DOI Creative Commons
Haritha L. Desu, Renaud Balthazard,

Audrey Daigneault

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 112, P. 105559 - 105559

Published: Jan. 20, 2025

Language: Английский

Citations

0
Association of Cytomegalovirus Serostatus with ELOVL2 Methylation: Implications for Lipid Metabolism, Inflammation, DNA Damage, and Repair Capacity in the MARK-AGE Study Population DOI
Robertina Giacconi, Chiara Pirazzini, Maria Giulia Bacalini

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112043 - 112043

Published: Feb. 1, 2025

Language: Английский

Citations

0
Advancing Precision Medicine: Uncovering Biomarkers and Strategies to Mitigate Immune-Related Adverse Events in Immune Checkpoint Inhibitors Therapy DOI Creative Commons

K L Nityashree,

P. Rachitha,

Shilpa Hanchinmane

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102035 - 102035

Published: April 1, 2025

Language: Английский

Citations

0
Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions DOI
Areez Shafqat, Mary Clare Masters, Utkarsh Tripathi

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400

Published: June 28, 2024

Language: Английский

Citations

3
Impact of Combined Antiretroviral Treatment (cART) on Latent Cytomegalovirus Infection DOI Creative Commons

Aura Temereanca,

Luminiţa Ene,

Grațiela Ţârdei

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(1), P. 76 - 76

Published: Jan. 9, 2025

Cytomegalovirus infections and reactivations are more frequent in people living with HIV (PLWH) have been associated increased risk of progression immunosenescence. We explored the impact combination antiretroviral therapy (cART) on latent CMV infection 225 young adults parenterally infected during childhood. Anti-CMV IgG antibodies were present 93.7% participants, lower levels correlating longer cART exposure better immunologic parameters. Patients immunological treatment success (CD4 > 350 cells/mL) had significantly titers compared to those suboptimal immune response cART. In total, 78% tested patients robust CMV-specific T-cell responses, measured by an IFN-γ release assay. A good was cellular immunity: level positively correlated CD4 CD8-T cell counts. No differences observed between suppressed/non-suppressed viremia terms humoral response. DNA detected only 17% among cART-induced recovery. The successful subsequent reconstitution may lead restoration responses effective control infection, limiting episodes reactivation HIV-positive individuals.

Language: Английский

Citations

0
Cytomegalovirus-Reactive IgG Correlates with Increased IL-6 and IL-1β Levels, Affecting Eating Behaviours and Tactile Sensitivity in Children with Autism DOI Creative Commons
Isti Anindya, Rini Sekartini, Ibnu Ariyanto

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 338 - 338

Published: Feb. 2, 2025

Background/Objectives: Elevated cytokine levels, including IL-6 and IL-1β, can contribute to persistent brain inflammation in children with autism cytomegalovirus (CMV) infection, exacerbating autism-related behaviours symptoms. This study evaluates the impact of CMV-induced increases on eating sensory profiles autism. Methods: A cross-sectional design was employed, involving aged two five years (CMV-reactive IgG), ASD (n= 98) TD (n = 96). Serological tests using ELISA were conducted measure IgG CMV, IL-6, IL-1β biomarkers. Eating evaluated BAMBI (Brief Autism Mealtime Behaviour Inventory), assessed SSP (Short Sensory Profile). Statistical analyses performed Spearman’s rank chi-square tests. Results: The results show that significantly affects children’s (p < 0.001), notable differences found between groups. Correlation analysis revealed a significant association CMV 0.026) 0.014) group. Additionally, (food refusal limited variety) correlated IL-1β. characteristics, such as tactile sensitivity, correlate 0.027) 0.002) Conclusions: These findings suggest CMV-infected are at increased risk dysregulation, contributing processing issues behaviours. Further research is needed enhance testing protocols better understand virus’s role development behavioural

Language: Английский

Citations

0
The Reduced Immunogenicity of Zoster Vaccines in CMV-Seropositive Older Adults Correlates with T Cell Imprinting DOI Creative Commons
Adriana Weinberg, Thao Vu, Michael Johnson

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 340 - 340

Published: March 22, 2025

Background: Cytomegalovirus (CMV) infection and age impact immune responses to vaccines. The effect of sex remains controversial. We investigated the relationship between cytomegalovirus-seropositivity, age, immunogenicity recombinant (RZV) live (ZVL) zoster vaccines in adults ≥50 years age. Methods: Varicella virus (VZV) glycoprotein E (gE)-specific antibody, antibody avidity, cell-mediated immunity (CMI) were measured pre-vaccination at regular intervals over 5 post-vaccination 80 RZV 79 ZVL recipients, including 91 cytomegalovirus-seropositive 90 female participants. Results: Differences associated with CMV-seropositivity: lower VZV-gE-CMI recipients after first dose vaccine, but no differences 2nd dose; VZV-gE-specific avidity recipients; more abundant Th1 senescent T cells (Tsen) less regulatory (Treg) tissue-resident memory (Trm). older age: cells. sex: none for either vaccine. cell subset abundance: higher Tsens Tregs or Trms post-dose 1 CMI Th1s concentrations. Conclusions: correlation CMV- age-associated subsets ZVLs RZVs suggests that imprinting contributes CMV on vaccine responses.

Language: Английский

Citations

0