Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes DOI Creative Commons
Maria Giuliani, Giorgia Bigossi, Giovanni Lai

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(5), P. 210 - 210

Published: May 3, 2024

Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population often require prolonged use of multiple drugs due to their chronic nature high proportion co-morbidities. Hence, research is constantly looking novel, effective molecules treat CVD T2DM with minimal side effects. Marine active compounds, holding great diversity chemical structures biological properties, represent interesting therapeutic candidates these age-related diseases. This review summarizes current state on marine compounds treatment T2DM, from pre-clinical studies clinical investigations approved drugs, highlighting potential development new therapies, together limitations translating results into human application.

Language: Английский

Targeting OPA1 protein for Therapeutic Intervention in Autosomal Dominant Optic Atrophy: In Silico Drug Discovery DOI
Azhar Iqbal, Muhammad Sajid, Abdelkrim Guendouzi

et al.

Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: unknown, P. 109013 - 109013

Published: March 1, 2025

Language: Английский

Citations

0
Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes DOI Creative Commons
Maria Giuliani, Giorgia Bigossi, Giovanni Lai

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(5), P. 210 - 210

Published: May 3, 2024

Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population often require prolonged use of multiple drugs due to their chronic nature high proportion co-morbidities. Hence, research is constantly looking novel, effective molecules treat CVD T2DM with minimal side effects. Marine active compounds, holding great diversity chemical structures biological properties, represent interesting therapeutic candidates these age-related diseases. This review summarizes current state on marine compounds treatment T2DM, from pre-clinical studies clinical investigations approved drugs, highlighting potential development new therapies, together limitations translating results into human application.

Language: Английский

Citations

2