The Role of miR‐144 in Inflammatory Diseases: A Review DOI Creative Commons
Shukun Hong,

Hongye Wang,

Lujun Qiao

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Background Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and considered key driver of many pathological conditions. MicroRNA‐144 (miR‐144) has emerged as critical regulator in inflammatory diseases, with its dysregulation implicated Understanding role mechanisms essential for developing therapeutic strategies. Objective This article aimed evaluate the miR‐144 diseases through literature review. Methods Electronic databases including PubMed, Web Science, Springer Link, China Knowledge Resource Integrated Database, Wanfang Data were searched relevant literature. The following keywords used combined differently according rules databases: “miR‐144,” “inflammation,” “inflammatory,” “immune response.” Studies investigating context inflammation included. extracted assess miR‐144's expression patterns association disease severity outcomes. Results was found be differentially expressed range sepsis, infectious respiratory cardiovascular digestive neuropsychiatric arthritis, pregnancy complications. varied depending on disease, both upregulation downregulation observed. modulation responses direct indirect targeting proteins pathways. review also highlighted potential diagnostic prognostic biomarker. Conclusion plays significant pathogenesis holds promise Its regulatory offer insights into processes may guide future However, further clinical studies are needed validate utility biomarker explore setting.

Language: Английский

The Role of miR‐144 in Inflammatory Diseases: A Review DOI Creative Commons
Shukun Hong,

Hongye Wang,

Lujun Qiao

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Background Inflammation, often caused by various stimuli, is a common response to tissue homeostasis disruptions and considered key driver of many pathological conditions. MicroRNA‐144 (miR‐144) has emerged as critical regulator in inflammatory diseases, with its dysregulation implicated Understanding role mechanisms essential for developing therapeutic strategies. Objective This article aimed evaluate the miR‐144 diseases through literature review. Methods Electronic databases including PubMed, Web Science, Springer Link, China Knowledge Resource Integrated Database, Wanfang Data were searched relevant literature. The following keywords used combined differently according rules databases: “miR‐144,” “inflammation,” “inflammatory,” “immune response.” Studies investigating context inflammation included. extracted assess miR‐144's expression patterns association disease severity outcomes. Results was found be differentially expressed range sepsis, infectious respiratory cardiovascular digestive neuropsychiatric arthritis, pregnancy complications. varied depending on disease, both upregulation downregulation observed. modulation responses direct indirect targeting proteins pathways. review also highlighted potential diagnostic prognostic biomarker. Conclusion plays significant pathogenesis holds promise Its regulatory offer insights into processes may guide future However, further clinical studies are needed validate utility biomarker explore setting.

Language: Английский

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