Effect of oleocanthal-rich olive oil on postprandial oxidative stress markers of patients with type 2 diabetes mellitus DOI Creative Commons

Maria Efthymia Katsa,

Andrea Paola Rojas Gil,

Evangelia-Mantelena Makri

et al.

Food & Nutrition Research, Journal Year: 2024, Volume and Issue: 68

Published: Nov. 11, 2024

Background: Type 2 diabetes mellitus (T2DM) is characterized by postprandial dysmetabolism, which has been linked to post-meal redox disturbances. Oleocanthal (OO), one of the most potent bioactive phenols extra virgin olive oil, shown modulating properties in vitro. However, its acute, vivo antioxidant have never studied before. Objective: The aim this study was investigate kinetics five markers (Thiobarbituric acid-reactive substances [TBARS] and glutathione peroxidase activity serum-GPx3 erythrocytes (GPx1), protein carbonyls serum) after consumption different meals. Design: Five isocaloric meals comprised white bread butter (BU) or plus ibuprofen (BU-IBU) oil poor OO oils containing 250 500 mg/Kg oleocanthal (OO250 OO500, respectively). We hypothesized that OO-rich will reduce oxidative stress T2DM patients compared other lipid sources. This involved 10 with had a cross-over design. Results: comparison incremental Area Under Curves (iAUCs) were able alleviate increments thiobarbituric (TBARS) GPx3 induce higher red blood cells (RBCs) GPx1 (P < 0.05). effect dose marker depended. Correlation analysis pooled sample demonstrated positive association between ex platelet sensitivity ADP iAUC TBARS. In conclusion, our can favorably modulate peroxidation RBC GPx when consumed as part carbohydrate meal. Discussion: demonstrates for first time that, apart from anti-inflammatory antiplatelet properties, also exert acute effects. Conclusion: finding emphasizes health benefits particularly those high content, patients.

Language: Английский

High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials DOI Creative Commons

Konstantina Liva,

Athanassios Panagiotopoulos, Alexandra Foscolou

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(3), P. 54 - 54

Published: March 7, 2025

Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as therapies for regulating molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents outcomes of clinical preclinical studies examining anti-obesity effects high extra virgin olive oil (HP-EVOO) its possible underlying mechanisms. Methods: Studies published between 2014 2024 were searched via MEDLINE, Scopus, Cochrane, Web Science, Semantic Scholar, Google Science.gov, Clinicaltrials.gov databases. A combination keywords Boolean logic was used to search throughout decade all databases, including “hyperglycemia” or “hypertension” “metabolic syndrome” “dyslipidemia” “hyperlipidemia” “hypoglycemia” “obesity” “macrovascular diabetic complications” “microvascular “cardiovascular disease” “overweight” “insulin sensitivity” resistance” “extra oil” “high “human” “animal model”. Results: 10-year literature survey identified 21 both animal models humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress endothelial function, potentially protecting against syndrome, hypertension type 2 diabetes, even compared EVOO. Moreover, HP-EVOO’s antiplatelet effect improvement HDL functionality reduce cardiovascular risk. Conclusions: evidence presented this study demonstrates represents effective preventive therapeutic dietary approach cardiometabolic diseases.

Language: Английский

Citations

0
Cardiovascular and Metabolic Benefits of Extra Virgin Olive Oil Phenolic Compounds: Mechanistic Insights from In Vivo Studies DOI Creative Commons
Gabriele Serreli, Anna Boronat, Rafael de la Torre

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(18), P. 1555 - 1555

Published: Sept. 16, 2024

Extra virgin olive oil (EVOO) represents a significant source of monounsaturated fatty acids (MUFA) and vitamin E, but it is also considered functional food, due to the content peculiar bioactive molecules, such as phenolic compounds, being able modulate various processes related aging most common metabolic degenerative diseases. A lot experimental research has focused on some these components, in cases, studies were performed vitro testing compounds at non-physiological concentrations achieving results that cannot easily be translated vivo. Recent clinical demonstrated vivo are regulate physiological functions prevent several pathological events including cardiovascular diseases (CVDs), which represent main causes death worldwide. This review aims sum up major evidence beneficial effects EVOO pathologies, describing evaluating efficacy relation mechanisms whole fraction its specific components.

Language: Английский

Citations

1
Exploring the Therapeutic Potential of Bioactive Compounds from Selected Plant Extracts of Mediterranean Diet Constituents for Cardiovascular Diseases: A Review of Mechanisms of Action, Clinical Evidence, and Adverse Effects DOI

Mateu Anguera-Tejedor,

Gabino Garrido, Bárbara B. Garrido‐Suárez

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105487 - 105487

Published: Nov. 17, 2024

Language: Английский

Citations

1
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment DOI Open Access
Paraskevi Papadopoulou, Alexia Polissidis,

Georgia Kythreoti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11040 - 11040

Published: Oct. 14, 2024

The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation cognitive impairment. This review examines the evidence for anti-inflammatory neuroprotective actions of their in treatment long COVID neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). Key findings suggest that exhibit antioxidant, anti-inflammatory, neuroprotective, antiviral properties, making them promising candidates intervention, especially when formulated unique combinations. Recommendations future research directions include elucidating molecular pathways through mechanistic studies, exploring implications polyphenol supplementation, conducting clinical trials assess efficacy safety. Investigating synergistic effects with other agents addressing different targets is suggested further exploration. reviewed strengthens translational value conditions involving dysfunction emphasizes novelty new formulations.

Language: Английский

Citations

1
Effect of oleocanthal-rich olive oil on postprandial oxidative stress markers of patients with type 2 diabetes mellitus DOI Creative Commons

Maria Efthymia Katsa,

Andrea Paola Rojas Gil,

Evangelia-Mantelena Makri

et al.

Food & Nutrition Research, Journal Year: 2024, Volume and Issue: 68

Published: Nov. 11, 2024

Background: Type 2 diabetes mellitus (T2DM) is characterized by postprandial dysmetabolism, which has been linked to post-meal redox disturbances. Oleocanthal (OO), one of the most potent bioactive phenols extra virgin olive oil, shown modulating properties in vitro. However, its acute, vivo antioxidant have never studied before. Objective: The aim this study was investigate kinetics five markers (Thiobarbituric acid-reactive substances [TBARS] and glutathione peroxidase activity serum-GPx3 erythrocytes (GPx1), protein carbonyls serum) after consumption different meals. Design: Five isocaloric meals comprised white bread butter (BU) or plus ibuprofen (BU-IBU) oil poor OO oils containing 250 500 mg/Kg oleocanthal (OO250 OO500, respectively). We hypothesized that OO-rich will reduce oxidative stress T2DM patients compared other lipid sources. This involved 10 with had a cross-over design. Results: comparison incremental Area Under Curves (iAUCs) were able alleviate increments thiobarbituric (TBARS) GPx3 induce higher red blood cells (RBCs) GPx1 (P < 0.05). effect dose marker depended. Correlation analysis pooled sample demonstrated positive association between ex platelet sensitivity ADP iAUC TBARS. In conclusion, our can favorably modulate peroxidation RBC GPx when consumed as part carbohydrate meal. Discussion: demonstrates for first time that, apart from anti-inflammatory antiplatelet properties, also exert acute effects. Conclusion: finding emphasizes health benefits particularly those high content, patients.

Language: Английский

Citations

0