Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine DOI Creative Commons

Qinyi Li,

Xiaohong Zhao, Huan Yang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1599 - 1599

Published: Nov. 27, 2024

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play critical roles in tumorigenesis, cancer progression, drug resistance. Persistent activation of ER system enhances survival capacities malignant tumor cells, including increased proliferation, invasion, resistance to treatment. Dysregulation function resultant is a common cellular therapies may lead cell death. Currently, growing evidence suggests that Traditional Chinese medicine (TCM), either as monotherapy or combination with other treatments, offers significant advantages preventing cancer, inhibiting growth, reducing surgical complications, improving sensitivity, mitigating drug-induced damage. Some these natural products have even entered clinical trials primary complementary anticancer agents. In this review, we summarize effects TCM monomers/natural on gastrointestinal (GI) tumors explore their mechanisms through modulation. We believe ongoing laboratory research development TCM-based hold considerable potential for advancing future treatments.

Language: Английский

Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer DOI Open Access

Diana-Theodora Morgos,

Constantin Ștefani,

Daniela Miricescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1848 - 1848

Published: Feb. 3, 2024

Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year.

Language: Английский

Citations

44
Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis DOI

Yongsen Li,

Mengyao Dong,

Hong Qin

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156441 - 156441

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cathepsin-K Targeted by Sanggenol L Induces Lethal Autophagy through ROS-Dependent AMPK/mTOR Signaling in Gastric Cancer DOI Creative Commons
Kui Zhang, Xin Hu, Jingjing Su

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100611 - 100611

Published: April 1, 2025

Language: Английский

Citations

0
Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT/GSK3β/NRF2 axis DOI
Xin Hu, Hongbo Chang, Yan Guo

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156789 - 156789

Published: April 1, 2025

Language: Английский

Citations

0
Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine DOI Creative Commons

Qinyi Li,

Xiaohong Zhao, Huan Yang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1599 - 1599

Published: Nov. 27, 2024

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play critical roles in tumorigenesis, cancer progression, drug resistance. Persistent activation of ER system enhances survival capacities malignant tumor cells, including increased proliferation, invasion, resistance to treatment. Dysregulation function resultant is a common cellular therapies may lead cell death. Currently, growing evidence suggests that Traditional Chinese medicine (TCM), either as monotherapy or combination with other treatments, offers significant advantages preventing cancer, inhibiting growth, reducing surgical complications, improving sensitivity, mitigating drug-induced damage. Some these natural products have even entered clinical trials primary complementary anticancer agents. In this review, we summarize effects TCM monomers/natural on gastrointestinal (GI) tumors explore their mechanisms through modulation. We believe ongoing laboratory research development TCM-based hold considerable potential for advancing future treatments.

Language: Английский

Citations

1