NeuroImage,
Journal Year:
2024,
Volume and Issue:
unknown, P. 120969 - 120969
Published: Dec. 1, 2024
The
preclinical
stage
of
Alzheimer's
Disease
(AD)
holds
great
potential
for
intervention,
therefore,
it
is
crucial
to
elucidate
the
neural
mechanisms
underlying
progression
subjective
cognitive
decline
(SCD).
Previous
studies
have
predominantly
focused
on
changes
in
cerebrum
associated
with
SCD,
but
relatively
neglected
cerebellum,
and
functional
relationship
between
cerebellum
cerebrum.
In
current
study,
we
employed
dynamic
connectivity
large-scale
brain
network
approaches
investigate
pathological
characteristics
states
cerebro-cerebellar
collaboration
across
different
SCD
(n
=
32)
healthy
elderly
29)
using
resting-state
fMRI.
Two-way
repeated
measures
ANOVA
permutation
t-tests
revealed
significant
group
difference,
individuals
exhibiting
shorter
state
duration
more
frequent
transitions
compared
three
states.
Additionally,
showed
lower
levels
intracerebellar
connectivity,
higher
cerebellar-cerebral
integration
representing
processing.
Furthermore,
hub
nodes
networks
shifted
These
findings
indicate
that
exhibits
greater
instability
can
compensate
negative
effects
early
disease
by
integrating
cerebellar
cerebral
networks,
thereby
maintaining
performance.
This
study
enhances
our
theoretical
understanding
stages
AD
provides
evidence
interventions
targeting
cerebellum.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: June 7, 2024
The
purpose
of
this
study
is
to
explore
whether
machine
learning
can
be
used
establish
an
effective
model
for
the
diagnosis
Parkinson's
disease
(PD)
by
using
texture
features
extracted
from
cerebellar
gray
matter
and
white
matter,
so
as
identify
subtle
changes
that
cannot
observed
naked
eye.
Medical Records,
Journal Year:
2025,
Volume and Issue:
7(1), P. 234 - 239
Published: Jan. 3, 2025
Aim:
The
aging
process
and
gender
are
thought
to
cause
changes
in
anatomical
regions
of
the
brain.
present
study
was
designed
age-
gender-related
morphometric
characteristics
cerebellum,
which
is
known
be
mainly
responsible
for
coordination
skeletal
system
balance.
Material
Method:
Brain
magnetic
resonance
(MR)
images
healthy
individuals
aged
25-55
years
were
analyzed.
MCRae
line
(MCL),
Klaus
index
(KI),
clivus
length
(LC),
supraocciput
(LSO),
diameter
posterior
cranial
fossa
(PDFC),
height
(PHFC),
lateral
cerebellum
(LDC),
(HCL),
width
(WCL),
cerebrum
(HC),
anterior
dural
angle
(ADAC),
cerebellar
(ACC),
anteroposterior
right
hemisphere
(RCHD)
left
(LCHD)
variables
measured.
Results:
It
has
been
determined
that
difference
between
groups
age,
MCL,
LSO,
PHFC,
HCL
statistically
significant.
genders
significant
KI,
LC,
LDC,
WCL,
HC,
RCHD,
LCHD
first
group,
second
HCL,
ACC,
third
group.
Conclusion:
Overall,
results
show
morphometry
Bolu
(Türkiye)
population.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 740 - 740
Published: Feb. 6, 2025
A
pentacyclic
triterpene,
oleanolic
acid
(OA),
has
anti-inflammatory
activity.
The
role
of
in
aging
is
poorly
understood,
and
the
regulatory
mechanism
IGF-1
signaling
still
not
fully
understood.
Thus,
we
hypothesized
that
OA
could
delay
by
regulating
PI3K/AKT/mTOR
pathway
via
insulin-like
growth
factor-1
(IGF-1).
This
study
initially
established
a
replicative
model
bleomycin-induced
human
dermal
fibroblast
(HDF)
mouse
embryonic
(MEF)
cell
lines.
On
this
basis,
inhibitors
or
recombinant
proteins
were
then
combined
with
(at
concentration
20
μM)
treated
for
72
h.
project
plans
to
detect
expression
aging-related
such
as
CDKN2A
(p16)
using
Western
blot
technology,
factors
Interleukin-1
beta
(IL-1β),
Interleukin-6
(IL-6),
Interleukin-8
(IL-8)
Real-Time
Quantitative
Polymerase
Chain
Reaction
(RT-qPCR),
Enzyme-Linked
Immunosorbent
Assay
(ELISA),
other
technologies,
combine
Senescence-Associated
β-Galactosidase
(SA-β-gal)
staining
changes
aging.
IGF-1,
PI3K/AKT/mTOR,
P16,
secretory
(SASP)
IL-1β,
IL-6,
IL-8
was
increased
senescent
cells.
After
treatment
jujuboside,
protein
decreased.
findings
suggested
slowed
down
inhibiting
through
IGF-1.
These
suggest
potential
new
drug
its
mechanisms
anti-aging.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1634 - 1634
Published: Feb. 14, 2025
Aging
and
age-related
neurodegenerative
disorders
are
characterized
by
the
dysfunction
or
loss
of
brain
nicotinic
acetylcholine
receptors
(nAChRs),
these
changes
may
be
related
to
other
senescence
markers,
such
as
oxidative
stress
DNA
repair
dysfunction.
However,
mechanism
nAChR
in
aging
modification
this
process
drugs
(e.g.,
memantine,
Mem)
not
yet
fully
understood.
To
study
whether
differences
expression
rat
occur
due
modulated
Mem,
we
analyzed
subunits
(at
RNA
protein
levels)
biomarkers
real-time
quantitative
polymerase
chain
reaction
(RQ-PCR)
Western
blot
validation.
Twenty-one
female
Wistar
rats
were
divided
into
four
groups,
depending
on
age,
oldest
group
received
injections
Mem
water
with
use
intragastric
catheters.
We
studied
cerebral
grey
matter
(CGM),
subcortical
white
(SCWM),
cerebellum
(Ce).
Results
showed
an
decrease
α7
mRNA
level
SCWM.
The
was
accompanied
reduced
8-oxoguanine
glycosylase
1
(OGG1)
increased
tumor
necrosis
factor
alpha
(TNFα)
level.
In
group,
observed
a
higher
SCWM
Ce.
Biomarker
levels
changed,
but
different
extent
area.
Importantly,
antioxidative
status
stopped
even
regressed
under
treatment.
After
two
weeks
treatment,
increase
TP53
8-oxo-2'deoxyguanosine
(8-oxo-2'dG)
observed.
conclude
that
administration
protective
against
mechanisms.
Biology,
Journal Year:
2025,
Volume and Issue:
14(3), P. 272 - 272
Published: March 7, 2025
Neural
excitatory/inhibitory
(E/I)
imbalance
plays
a
pivotal
role
in
the
aging
process.
However,
despite
its
significant
impact,
of
E/I
motor
dysfunction
and
neurodegenerative
diseases
has
not
received
sufficient
attention.
This
review
explores
mechanisms
underlying
through
lens
balance,
emphasizing
genetic
molecular
factors
that
contribute
to
this
(such
as
SCN2A,
CACNA1C,
GABRB3,
GRIN2A,
SYT,
BDNF…).
Key
regulatory
genes,
including
REST,
vps-34,
STXBP1,
are
examined
for
their
roles
modulating
synaptic
activity
neuronal
function
during
aging.
With
insights
drawn
from
ALS,
we
discuss
how
disruptions
balance
pathophysiology
age-related
dysfunction.
The
genes
discussed
above
exhibit
certain
association
with
neuron
(like
ALS),
relationship
had
been
previously
recognized.
Innovative
therapies,
such
gene
editing
technology
optogenetic
manipulation,
emerging
promising
tools
restoring
offering
hope
ameliorating
deficits
potential
these
technologies
intervene
aging-related
diseases,
challenges
direct
application
human
conditions.
