NeuroImage,
Journal Year:
2024,
Volume and Issue:
unknown, P. 120969 - 120969
Published: Dec. 1, 2024
The
preclinical
stage
of
Alzheimer's
Disease
(AD)
holds
great
potential
for
intervention,
therefore,
it
is
crucial
to
elucidate
the
neural
mechanisms
underlying
progression
subjective
cognitive
decline
(SCD).
Previous
studies
have
predominantly
focused
on
changes
in
cerebrum
associated
with
SCD,
but
relatively
neglected
cerebellum,
and
functional
relationship
between
cerebellum
cerebrum.
In
current
study,
we
employed
dynamic
connectivity
large-scale
brain
network
approaches
investigate
pathological
characteristics
states
cerebro-cerebellar
collaboration
across
different
SCD
(n
=
32)
healthy
elderly
29)
using
resting-state
fMRI.
Two-way
repeated
measures
ANOVA
permutation
t-tests
revealed
significant
group
difference,
individuals
exhibiting
shorter
state
duration
more
frequent
transitions
compared
three
states.
Additionally,
showed
lower
levels
intracerebellar
connectivity,
higher
cerebellar-cerebral
integration
representing
processing.
Furthermore,
hub
nodes
networks
shifted
These
findings
indicate
that
exhibits
greater
instability
can
compensate
negative
effects
early
disease
by
integrating
cerebellar
cerebral
networks,
thereby
maintaining
performance.
This
study
enhances
our
theoretical
understanding
stages
AD
provides
evidence
interventions
targeting
cerebellum.
International Journal of Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 23
Published: April 25, 2025
Piezo1
is
a
ubiquitously
expressed
non-selective
cation
channel
protein
found
across
various
species.
It
possesses
the
ability
to
detect
and
respond
external
mechanical
forces,
converting
cues
into
intracellular
bioelectrical
events,
thereby
facilitating
propagation
of
electrochemical
signals.
Within
nervous
system,
integral
synaptogenesis
myelination,
modulation
pro-inflammatory
mediators,
neuropathic
pain,
cognitive
processes,
angiogenesis,
regulation
cerebral
hemodynamics,
consequently
impacting
pathogenesis
progression
neurological
disorders.
This
review
meticulously
summarizes
synthesizes
existing
literature
provide
an
exhaustive
overview
Piezo1's
roles
mechanisms
in
spectrum
diseases,
including
neurodegenerative
disorders,
cerebrovascular
accidents,
traumatic
brain
injuries,
gliomas,
multiple
sclerosis,
epilepsy.
Additionally,
it
explores
potential
therapeutic
applications
targeting
Piezo1.
The
discussion
also
encompasses
current
research
limitations,
imperative
need
for
future
investigations,
prospective
strategies.
Our
analysis
indicates
that
susceptibility
gene
conditions,
its
expression
inhibition
may
confer
benefits.
In
summary,
this
comprehensive
offers
novel
insights
involvement
diseases
establishes
theoretical
groundwork
development
Piezo1-targeted
interventions.
Abstract
Age-related
neurodegenerative
diseases
involve
reduced
cell
numbers
and
impaired
behavioral
capacity.
Neurodegeneration
deficits
also
occur
during
aging,
notably
in
the
absence
of
disease.
The
cerebellum,
which
modulates
movement
cognition,
is
susceptible
to
loss
both
aging
Here,
we
demonstrate
that
cerebellar
Purkinje
aged
mice
not
spatially
random
but
rather
occurs
a
pattern
parasagittal
stripes.
We
find
exhibit
motor
coordination
more
severe
tremor
compared
younger
mice.
However,
relationship
between
patterned
dysfunction
straightforward.
Examination
postmortem
samples
human
cerebella
from
neurologically
typical
individuals
supports
presence
selective
cells
aging.
These
data
reveal
spatiotemporal
cellular
substrate
for
cerebellum
may
inform
about
how
neuronal
vulnerability
leads
neurodegeneration
ensuing
deterioration
behavior.
Abstract
Age-related
neurodegenerative
diseases
involve
reduced
cell
numbers
and
impaired
behavioral
capacity.
Neurodegeneration
deficits
also
occur
during
aging,
notably
in
the
absence
of
disease.
The
cerebellum,
which
modulates
movement
cognition,
is
susceptible
to
loss
both
aging
Here,
we
demonstrate
that
cerebellar
Purkinje
aged
mice
not
spatially
random
but
rather
occurs
a
pattern
parasagittal
stripes.
We
find
exhibit
motor
coordination
more
severe
tremor
compared
younger
mice.
However,
relationship
between
patterned
dysfunction
straightforward.
Examination
postmortem
samples
human
cerebella
from
neurologically
typical
individuals
supports
presence
selective
cells
aging.
These
data
reveal
spatiotemporal
cellular
substrate
for
cerebellum
may
inform
about
how
neuronal
vulnerability
leads
neurodegeneration
ensuing
deterioration
behavior.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 740 - 740
Published: Feb. 6, 2025
A
pentacyclic
triterpene,
oleanolic
acid
(OA),
has
anti-inflammatory
activity.
The
role
of
in
aging
is
poorly
understood,
and
the
regulatory
mechanism
IGF-1
signaling
still
not
fully
understood.
Thus,
we
hypothesized
that
OA
could
delay
by
regulating
PI3K/AKT/mTOR
pathway
via
insulin-like
growth
factor-1
(IGF-1).
This
study
initially
established
a
replicative
model
bleomycin-induced
human
dermal
fibroblast
(HDF)
mouse
embryonic
(MEF)
cell
lines.
On
this
basis,
inhibitors
or
recombinant
proteins
were
then
combined
with
(at
concentration
20
μM)
treated
for
72
h.
project
plans
to
detect
expression
aging-related
such
as
CDKN2A
(p16)
using
Western
blot
technology,
factors
Interleukin-1
beta
(IL-1β),
Interleukin-6
(IL-6),
Interleukin-8
(IL-8)
Real-Time
Quantitative
Polymerase
Chain
Reaction
(RT-qPCR),
Enzyme-Linked
Immunosorbent
Assay
(ELISA),
other
technologies,
combine
Senescence-Associated
β-Galactosidase
(SA-β-gal)
staining
changes
aging.
IGF-1,
PI3K/AKT/mTOR,
P16,
secretory
(SASP)
IL-1β,
IL-6,
IL-8
was
increased
senescent
cells.
After
treatment
jujuboside,
protein
decreased.
findings
suggested
slowed
down
inhibiting
through
IGF-1.
These
suggest
potential
new
drug
its
mechanisms
anti-aging.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Nov. 29, 2024
It
is
crucial
to
identify
biomarkers
that
influence
the
aging
process
and
associated
health
risks,
given
growing
severity
of
global
population
issue.
The
objectives
our
research
were
evaluate
cardiac
metabolic
index
(CMI)
as
a
novel
biomarker
for
identifying
individuals
at
increased
risk
accelerated
biological
assess
its
use
in
guiding
preventive
strategies
aging-related
risks.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(20), P. 4973 - 4973
Published: Oct. 21, 2024
Human
milk
comprehensively
meets
the
nutritional
needs
of
a
child,
providing
not
only
structural
and
energy
components
but
also
various
bioactive
factors.
Among
these,
neurotrophic
factors
hormones
involved
in
metabolic
processes
deserve
special
attention.
Studies
using
enzyme-linked
immunosorbent
assays
compared
content
factors-CNTF,
NT-3,
NGF-and
hormones,
leptin
insulin,
two
groups
breast
samples:
early
lactation
(1-3
months)
extended
(>6
months,
up
to
12
months).
The
results
indicated
changes
insulin
levels
as
period
extended.
NGF,
leptin,
were
present
samples
from
both
study
groups,
with
being
higher
group.
CNTF
NT-3
detected
any
either
analyses
confirmed
that
human
women
who
breastfeed
for
periods
remains
source
biologically
active
macronutrients
support
child's
development
health.
