International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12784 - 12784
Published: Nov. 28, 2024
Resolvins
are
specialized
pro-resolving
mediators
(SPMs)
derived
from
omega-3
fatty
acids
that
play
a
critical
role
in
resolving
inflammation
and
restoring
tissues
to
state
of
health
after
an
immune
response.
Their
chronic
inflammatory
conditions
highlights
their
importance
maintaining
balance
between
effective
response
the
resolution
prevent
tissue
damage.
Periodontal
disease
is
condition
affecting
surrounding
teeth,
leading
gum
damage
bone
loss.
Chronic
periodontal
can
exacerbate
systemic
influence
other
conditions,
such
as
diabetes.
There
bidirectional
relationship
diabetes
disease,
both
characterized
by
oral
complications.
This
narrative
review
aims
synthesize
current
knowledge
on
how
resolvins
pathways
repair
mechanism
patients
with
type
2
Furthermore,
this
serves
foundation
for
developing
targeted
therapeutic
strategies,
addressing
pressing
need
treatments
consider
outcomes.
Oral Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 3, 2024
ABSTRACT
Objective
The
aim
of
this
study
is
to
explore
the
mechanism
benzylurea
in
inflammatory
injury
human
periodontal
ligament
fibroblasts
(hPDLFs).
Methods
An
inflammation
model
hPDLFs
was
established
using
LPS.
Nuclear
transport
nuclear
transcription
factor‐κB
(NF‐κB),
secretion
cytokines,
and
morphology
distribution
F‐actin
were
determined.
Mitochondrial
function
assessed
by
measuring
mitochondrial
membrane
potential
(MMP),
permeability
transition
pore
(mPTP),
reactive
oxygen
species
(ROS)
levels.
expression
carrier
homolog
2
(MTCH2)
Cytochrome
b5
type
B
(CYB5B)
detected.
Results
Benzylurea
alleviated
effects
lipopolysaccharide
(LPS)
on
proliferation
apoptosis
hPDLFs.
It
reduced
release
cytokines
inhibited
NF‐κB
translocation.
improved
regulating
MMP
preventing
excessive
mPTP
opening.
Furthermore,
LPS
elevated
MTCH2
CYB5B
However,
these
can
be
benzylurea.
altered
directly
affected
expression,
activation
translocation
NF‐κB.
Conclusion
may
act
as
an
effector
MTCH2,
with
enhancing
protecting
from
LPS‐induced
through
MTCH2.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Nov. 22, 2024
To
investigate
the
difference
of
salivary
microbiome
composition
in
type
2
diabetes
mellitus
with
different
stages
periodontitis.
105
patients
diagnosed
T2DM
were
divided
into
four
groups
according
to
Stage
periodontitis.The
16
S
rDNA
hypervariable
regions
V3-V4
amplified
by
polymerase
chain
reaction
(PCR)
after
saliva
DNA
was
extracted.
The
library
constructed
and
Illumina
sequencing
performed.
results
compared
silva
138
database,
studied
species
analysis,
principal
coordinate
correlation
analysis.
There
significant
differences
alpha
diversity
among
groups,
but
no
Beta
diversity.
At
phylum
level,
there
one
differential
bacteria—Firmicutes,
while
at
genus
bacteria.
Spearman's
analysis
identified
correlations
between
periodontal
health
indices
(PLI,
SBI,
AL
PD)
abundances
over
13
genera,
including
Streptococcus,
Gemella
Capnocytophaga,
etc.
Additionally,
duration
exhibited
a
positive
PD.
are
microbial
is
some
microbiota
inflammation.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1450 - 1450
Published: Nov. 26, 2024
Periodontitis,
an
oral
disease
initiated
by
a
dysbiotic
dental
biofilm,
has
unclear
response
to
photobiomodulation
(PBM)
as
adjunctive
treatment.
This
study
investigates
the
effects
of
PBM
on
reactive
oxygen
species
(ROS),
apoptosis,
oxidative
stress,
and
inflammatory
markers
in
periodontitis
model
using
C57BL/6
mice,
divided
into
four
groups:
control
(C),
+
(C
PBM),
(P),
(P
PBM).
An
infrared
diode
laser
(808
nm,
133.3
J/cm2,
4
J/session)
was
applied
for
three
days.
reduced
superoxide
anions,
hydrogen
peroxide,
apoptosis
gingival
cells,
while
decreasing
systemic
inflammation
protein
oxidation.
In
P
group,
pro-inflammatory
cytokines
IL-6
IL-12p70
decreased,
whereas
IL-10
increased,
suggesting
improvements
stress
profiles.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12784 - 12784
Published: Nov. 28, 2024
Resolvins
are
specialized
pro-resolving
mediators
(SPMs)
derived
from
omega-3
fatty
acids
that
play
a
critical
role
in
resolving
inflammation
and
restoring
tissues
to
state
of
health
after
an
immune
response.
Their
chronic
inflammatory
conditions
highlights
their
importance
maintaining
balance
between
effective
response
the
resolution
prevent
tissue
damage.
Periodontal
disease
is
condition
affecting
surrounding
teeth,
leading
gum
damage
bone
loss.
Chronic
periodontal
can
exacerbate
systemic
influence
other
conditions,
such
as
diabetes.
There
bidirectional
relationship
diabetes
disease,
both
characterized
by
oral
complications.
This
narrative
review
aims
synthesize
current
knowledge
on
how
resolvins
pathways
repair
mechanism
patients
with
type
2
Furthermore,
this
serves
foundation
for
developing
targeted
therapeutic
strategies,
addressing
pressing
need
treatments
consider
outcomes.
