Unraveling the Heterogeneity of Deficiency of Mismatch Repair Proteins in Endometrial Cancer: Predictive Biomarkers and Assessment Challenges DOI Open Access
Filomena Marino Carvalho, Jesus Paula Carvalho

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3452 - 3452

Published: Oct. 11, 2024

Endometrial cancer (EC) poses a significant global health challenge, with increasing prevalence in 26 of 43 countries and over 13,000 deaths projected the United States by 2024. This rise correlates aging populations, obesity epidemic, changing reproductive patterns, including delayed childbearing. Despite early diagnosis 67% cases, approximately 30% cases present regional or distant spread, leading to nearly 20% mortality rates. Unlike many cancers, EC rates are escalating, outpacing therapeutic advancements until recently. One reasons for this was lack effective options advanced disease The introduction immunotherapy has marked turning point treatment, particularly benefiting patients defects mismatch repair proteins (dMMRs). However, dMMR status alone does not ensure favorable response, underscoring need precise patient selection. review explores pivotal role EC, emphasizing their heterogeneity, challenges assessment, potential as predictive biomarkers.

Language: Английский

Expression and prognostic value of EGF-like domain multiple 6 in uterine corpus endometrial carcinoma and its correlation with immune cell infiltration DOI

Qiannan Li,

Nuerbiya Muheteer,

Gulibositan Ayoufu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Uterine corpus endometrial carcinoma (UCEC) represents a common malignancy affecting the female reproductive tract, distinguished by elevated rates of both morbidity and mortality. This study investigates EGF-like domain multiple 6 (EGFL6) expression as potential diagnostic prognostic biomarker in UCEC. RNA sequencing data along with clinical information UCEC patients were sourced from The Cancer Genome Atlas (TCGA). Logistic regression analysis assessed correlations between EGFL6 features. Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA) conducted to evaluate EGFL6-related biological characteristics signaling pathways. Immunohistochemistry (IHC) was performed on tissue microarrays assess levels. Kaplan-Meier method Cox analyses evaluated significance EGFL6. Three nomograms developed predict overall survival (OS), disease-specific (DSS), progression-free interval (PFI) probabilities at one, three, five years following diagnosis. validated through quantitative real-time PCR (RT-qPCR). Our findings demonstrate that is markedly overexpressed associated unfavorable characteristics, including stage histological type. GO/KEGG GSEA highlighted its possible involvement critical pathways, such MAPK Ras signaling. Additionally, decreased immune cell infiltration, particularly regulatory T cells (Tregs) (r = -0.219, p < 0.001) CD8 + -0.217, 0.001). Overall, linked poor patient prognosis. In conclusion, presents itself for UCEC, which could greatly influence improvement evaluations.

Language: Английский

Citations

0
Role of signaling pathways in endometrial cancer DOI
Nikita Balhara, Ritu Yadav, Meenakshi Chauhan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 21, 2025

Language: Английский

Citations

0
Prognostic role of C-reactive protein in patients with endometrial cancer: a meta-analysis DOI

Xieyan Yu,

Xiaoxing Zhang

Biomarkers in Medicine, Journal Year: 2024, Volume and Issue: 18(6), P. 279 - 289

Published: March 18, 2024

The present meta-analysis aimed to explore the association between C-reactive protein (CRP) levels and prognosis of patients with endometrial cancer (EC).

Language: Английский

Citations

3
The Clinicopathological Features and Prognoses of Lower Uterine Segment Cancer: A Retrospective, Single-Center Cohort Study DOI Creative Commons

Hao Wang,

Yinbo Xiao,

Yumeng Cai

et al.

International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 1401 - 1411

Published: Aug. 1, 2024

Introduction:This study used single-center data to analyze the clinicopathological features of site-specific endometrial cancer.Methods: Patients with carcinoma who had undergone surgery at Peking Union Medical College Hospital, China, between March 2016 and January 2022 were enrolled.Clinical information pathological characteristics summarized, microsatellite status was analyzed using immunohistochemical method.Patient prognoses measured in terms rates overall survival progression-free survival.Results: The mean patient age 49 years (ranging: from 25 76 old), there no difference endometrioid type II LUSC.The ER PR expression ratios 80.4% 64.3%, respectively, this LUSC cohort, MMR deficiency ratio 33.9%, including 39.6% 15.4% carcinoma.Combined MSH2&MSH6 loss more common than combined MLH1&PMS2 being unexpressed (16.1% vs 12.5%), dMMR patients differed significantly pMMR group vascular invasion (P=0.003).The combination chemotherapy radiotherapy did not provide a statistically significant improvement prognosis compared alone. Conclusion:The results showed that tended be younger their tumors less hormone markers.The biological behavior both cancer EC may similar when occurs area.Furthermore, tumor also higher incidence invasion, improvement.Thus, successful treatment requires aggressive surgical intervention effective postoperative approach.

Language: Английский

Citations

1
A 10-Year Retrospective Cohort Study of Endometrial Cancer Outcomes and Associations with Lymphovascular Invasion: A Single-Center Study from Germany DOI Creative Commons

Alexandra Nienhaus,

Rahavie Rajakulendran,

Elena Bernad

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(15), P. 1686 - 1686

Published: Aug. 4, 2024

This 10-year retrospective cohort study at a single-center clinic in Germany aimed to analyze the outcomes of endometrial cancer patients and explore impact lymphovascular invasion (LV) on patient disease-free survival (DFS). Identifying correlations among demographic data, tumor characteristics, treatment modalities, could enhance management improve rates. The encompassed diagnosed treated for from January 2010 December 2020. Clinical pathological data were extracted medical records 311 patients, focusing variables such as age, histological type, grade, type surgical treatment, adjuvant therapies. Survival analysis was conducted using Kaplan-Meier method multivariate Cox proportional hazard models identify factors independently associated with survival. demonstrated that significantly impacted (log-rank

Language: Английский

Citations

0
Predictive biomarkers in endometrial carcinomas: a review of their relevance in daily anatomic pathology DOI Creative Commons

Janaína Nagel,

Rafael Bispo Paschoalini, Patrícia Barreto

et al.

Surgical and Experimental Pathology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 9, 2024

Abstract Endometrial carcinoma (EC) is the most common gynecologic malignancy in high-income countries, with its incidence and mortality rising globally, particularly countries undergoing rapid socioeconomic transitions. Over past decade, management of EC has shifted towards molecular classification biomarker-driven therapies. This shift began 2013 discovery 4 prognostic subgroups by The Cancer Genome Atlas (TCGA). Following TCGA discovery, Proactive Molecular Risk Classifiers for (ProMisE) TransPORTEC initiative have provided pragmatic classifiers combining next-generation sequencing (NGS) surrogate immunohistochemical markers to TCGA’s categorization: Mismatch Repair Deficient (MMRd); p53-abnormal (p53abn); No Specific Profile (NSMP); POLE -mutant ( mut). These not only provide insights into biological behavior but also strong clinical relevance implications. In line these advancements, World Health Organization (WHO) endorsed 2020, advocating integration pathology reports. 2023, Federation International Gynecology Obstetrics (FIGO) proposed a new staging system that integrates histological parameters profiles routine practice. use complete surrogates all cases, whenever resources permit, intended promote risk-group stratification, data collection, Lynch Syndrome (LS) screening, potentially influence adjuvant systemic treatment decisions, as well predict efficacy Immune Checkpoint Inhibitors (ICI). Consequently, evolving landscape predictive biomarkers gained importance daily oncology practice, profoundly changing role pathologists. Pathologists are now crucial interpreting information participating members multidisciplinary teams therapeutic decisions. review article aims emphasize encourage pathologists become familiar their anatomical

Language: Английский

Citations

0
Unraveling the Heterogeneity of Deficiency of Mismatch Repair Proteins in Endometrial Cancer: Predictive Biomarkers and Assessment Challenges DOI Open Access
Filomena Marino Carvalho, Jesus Paula Carvalho

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3452 - 3452

Published: Oct. 11, 2024

Endometrial cancer (EC) poses a significant global health challenge, with increasing prevalence in 26 of 43 countries and over 13,000 deaths projected the United States by 2024. This rise correlates aging populations, obesity epidemic, changing reproductive patterns, including delayed childbearing. Despite early diagnosis 67% cases, approximately 30% cases present regional or distant spread, leading to nearly 20% mortality rates. Unlike many cancers, EC rates are escalating, outpacing therapeutic advancements until recently. One reasons for this was lack effective options advanced disease The introduction immunotherapy has marked turning point treatment, particularly benefiting patients defects mismatch repair proteins (dMMRs). However, dMMR status alone does not ensure favorable response, underscoring need precise patient selection. review explores pivotal role EC, emphasizing their heterogeneity, challenges assessment, potential as predictive biomarkers.

Language: Английский

Citations

0