Olfactory Projections to Locomotor Control Centers in the Sea Lamprey DOI Open Access
Philippe‐Antoine Beauséjour,

Jean-Christophe Veilleux,

Steven Condamine

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9370 - 9370

Published: Aug. 29, 2024

Although olfaction is well known to guide animal behavior, the neural circuits underlying motor responses elicited by olfactory inputs are poorly understood. In sea lamprey, anatomical evidence shows that project posterior tuberculum (PT), a structure containing dopaminergic (DA) neurons homologous mammalian ventral tegmental area and substantia nigra pars compacta. Olfactory travel directly from medial bulb (medOB) or indirectly through main lateral pallium (LPal). Here, we characterized transmission of PT in Petromyzon marinus. Abundant projections medOB were observed close DA PT. Moreover, electrophysiological experiments revealed activated both LPal, calcium imaging indicated signal then relayed mesencephalic locomotor region initiate locomotion. semi-intact preparations, stimulation LPal induced locomotion was tightly associated with activity active throughout spontaneously occurring bouts. Altogether, our observations suggest convey PT, which turn activate brainstem command system elicit

Language: Английский

Cys fluorescent probe precisely modified by fluorine revealing oxidative stress mechanism in Parkinson's disease DOI
Yuting Wang,

Huming Yan,

Fangjun Huo

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102401 - 102401

Published: July 13, 2024

Language: Английский

Citations

5
Pterostilbene alleviates MPTP-induced neurotoxicity by targeting neuroinflammation and oxidative stress DOI

Yepeng Fan,

Feng He, Mulan Chen

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 729, P. 150358 - 150358

Published: July 5, 2024

Language: Английский

Citations

3
Gray matter structural and functional brain abnormalities in Parkinson’s disease: a meta-analysis of VBM and ALFF data DOI
Lu Wang,

Xin Xiong,

Junqi Liu

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 19, 2025

Language: Английский

Citations

0
Advanced nanocomposite-based electrochemical sensor for ultra-sensitive dopamine detection in physiological fluids DOI Creative Commons

Megha Shinde,

Gymama Slaughter

Frontiers in Lab on a Chip Technologies, Journal Year: 2025, Volume and Issue: 4

Published: March 25, 2025

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring flexible laser-induced graphene (LIG) modified with unique nanocomposite comprising Nb 4 C 3 T x MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. performance of fabricated via cyclic voltammetry showed significant activity upon modification LIG an increased peak anodic current (I pa ) from 43 μA 104 μA. demonstrated high electrocatalytic wide linear detection range 1 nM mM DA excellent sensitivity 0.283 μA/nM cm −2 , ultralow limit 70 pM. exhibited good recovery in biological samples remarkable selectivity DA, effectively distinguishing it common interfering compounds such as uric acid, ascorbic glucose, sodium chloride, their mixtures. platform provides reliable accurate approach detecting even complex matrices at applications highlighting its potential advanced biosensing applications.

Language: Английский

Citations

0
Aging accelerates locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression DOI

Isabel Soto,

Robert McManus,

Walter Navarrete

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 376, P. 114771 - 114771

Published: April 4, 2024

Language: Английский

Citations

3
Moderate intensity aerobic exercise alleviates motor deficits in 6-OHDA lesioned rats and reduces serum levels of biomarkers of Parkinson's disease severity without recovery of striatal dopamine or tyrosine hydroxylase DOI Creative Commons

Ella A. Kasanga,

Isabel Soto,

Ashley Centner

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114875 - 114875

Published: June 27, 2024

Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD) patients points to activation neurobiological mechanisms that may be targetable therapeutic approaches. However, evidence for AE-related recovery striatal dopamine (DA) signaling or tyrosine hydroxylase (TH) loss has been inconsistent rodent studies. This ambiguity related the timing AE intervention relation status nigrostriatal neuron loss. Here, we replicated human PD at diagnosis establishing with >80% DA and TH prior initiating AE, assessed its potential alleviate decline restore We also evaluated if serum levels neurofilament light (NfL) glial fibrillary acidic protein (GFAP), biomarkers severity, changed response AE. 6-hydroxydopamine (6-OHDA) was infused unilaterally into rat medial forebrain bundle induce progressive over 28 days. Moderate intensity (3× per week, 40 min/session), began 8–10 days post-lesion following establishment impaired forelimb use. Striatal tissue DA, mRNA, NfL/GFAP were determined 3-wks after began. Despite severe depletion initiation, use deficits hypokinesia onset alleviated without loss, but reduced NfL GFAP levels. proof-of-concept study shows alleviates when initiated obligate protein. Moreover, reduction serve as objective blood-based efficacy.

Language: Английский

Citations

1
A Novel Approach to Tyrosinase-Based Biosensors: Electrode Reactions and Biological Measurement DOI Creative Commons

Masumeh Goodarzi,

Hosna Tavakoli,

Maryam Khalaj

et al.

Biosensors and Bioelectronics X, Journal Year: 2024, Volume and Issue: unknown, P. 100550 - 100550

Published: Oct. 1, 2024

Language: Английский

Citations

1
Reproductive Technologies and Parkinson’s disease: A Study of the Substantia Nigra and Motor Functions in C57BL/6 and B6.CG-TG Mice DOI

V. S. Kozeneva,

I. N. Rozhkova,

E. Yu. Brusentsev

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(6), P. 2434 - 2450

Published: Nov. 1, 2024

Language: Английский

Citations

1
Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression DOI Open Access

Isabel Soto,

Robert McManus,

Walter Navarrete-Barahona

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Parkinson's disease (PD) rodent models provide insight into the relationship between nigrostriatal dopamine (DA) signaling and locomotor function. Although toxin-based rat produce frank neuron loss eventual motor decline characteristic of PD, rapid nature neuronal may not adequately translate premotor traits, such as cognitive decline. Unfortunately, genetic PD models, like Pink1 knockout (KO) rat, often fail to replicate differential severity striatal DA tyrosine hydroxylase (TH) loss, a bradykinetic phenotype, reminiscent human PD. To elucidate this inconsistency, we evaluated aging progression factor in timing non-motor impairments. Male PINK1 KO age-matched wild type (WT) rats were longitudinal study from 3 16 months old one cohort, cross-sectional young adult (6-7 months) aged (18-19 another cohort. Young exhibited hyperkinetic behavior associated with elevated TH substantia nigra (SN), which decreased therein, but striatum, rats. Additionally, norepinephrine levels prefrontal cortex (PFC), paired higher content KO. younger age onset characterizes familial forms our results underscore critical need consider age-related factors. Moreover, indicate that compensatory mechanisms exist preserve function, evidenced by increased SN early lifespan, response deficient declines impairment.

Language: Английский

Citations

0
5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses DOI Open Access

Maya Molinari,

Ori J. Lieberman, David Sulzer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

Abstract The substantia nigra pars reticulata (SNr), a crucial basal ganglia output nucleus, contains dense expression of dopamine D1 receptors (D1Rs), along with dendrites belonging to dopaminergic neurons compacta. These D1Rs are primarily located on the terminals striatonigral medium spiny neurons, suggesting their involvement in regulation neurotransmitter release from direct pathway response somatodendritic release. To explore hypothesis that modulate GABA synapses, we conducted optical recordings activity and postsynaptic patch-clamp SNr presence D1R agonists. We found inhibits optogenetically triggered by modulating vesicle fusion Ca 2+ influx boutons. Notably, effect DA was independent but required activation 5-HT1B receptors. Our results suggest serotonergic mechanism involved therapeutic actions medications for Parkinson’s disease psychostimulant-related disorders.

Language: Английский

Citations

0