The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 178031 - 178031
Published: Dec. 16, 2024
Language: Английский
Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)
Published: June 5, 2024
Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve vital mediators in intercellular communication material exchange. Endothelial progenitor cells (EPCs), recognized precursors vascular endothelial (ECs), garnered considerable attention recent years due potential therapeutic value their derived extracellular (EPC-EVs) context CVDs. This comprehensive review systematically explores origins, characteristics, functions EPCs, alongside classification, properties, biogenesis, extraction techniques EVs, with particular emphasis on protective roles Additionally, we delve into essential bioactive components EPC-EVs, including microRNAs, long non-coding RNAs, proteins, analyzing beneficial effects promoting angiogenesis, anti-inflammatory anti-oxidant activities, anti-fibrosis, anti-apoptosis, myocardial regeneration. Furthermore, this comprehensively investigates EPC-EVs across various CVDs, encompassing acute infarction, ischemia-reperfusion injury, atherosclerosis, non-ischemic cardiomyopathies, diabetic cardiovascular disease. Lastly, summarize challenges associated clinical application outline future directions, aiming offer valuable resource for both theoretical insights practical applications managing
Language: Английский
Citations
7
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 77 - 77
Published: Jan. 10, 2025
Our group has recently demonstrated that exercise intervention affects the release and function of bone marrow endothelial progenitor cell-derived extracellular vesicles (EVs) in transgenic hypertensive mice. Whether such an regimen can impact circulating EVs (cEVs) remains unknown. In this study, we investigated influence on cEV level function. Transgenic mice (Alb1-Ren) underwent 8-week treadmill (10 m/min for 1 h, 5 days per week). Age- sex-matched sedentary Alb1-Ren served as controls. cEVs were isolated from blood exercised are denoted ET-cEV nET-cEV, respectively. labeled to determine their uptake efficiency pathways. The functions assessed Angiotensin II (Ang II) plus hypoxia-injured cerebral microvascular cell (mBMEC) injury model. Cellular migration ability oxidative stress evaluated. We found stimulated release, ET-cEVs more prone be internalized by mBMECs. internalization was mediated macropinocytosis endocytosis Functional studies showed improve compromised capability mBMECs challenged Ang hypoxia. Additionally, treatment upregulated expression p-Akt/Akt Compared nET-cEVs, significantly reduced ROS overproduction mBMECs, associated with decreased Nox2 expression. All these findings suggest exercise-intervened protect cells against hypoxic injury.
Language: Английский
Citations
0
Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1309 - 1309
Published: Aug. 6, 2024
Perivascular adipose tissue (PVAT) is a special deposit of fat surrounding the vasculature. Previous studies suggest that PVAT modulates vasculature function in physiological conditions and implicated pathogenesis vascular diseases. Understanding how influences disease progression important. Extracellular vesicles (EVs) are novel mediators intercellular communication. EVs encapsulate molecular cargo such as proteins, lipids, nucleic acids. can influence cellular functions by transferring carried bioactive molecules. Emerging evidence indicates PVAT-derived play an important role under health conditions. This review will focus on roles PVAT-EVs obesity, diabetic, metabolic syndrome-related diseases, offering insights into therapeutic targets for
Language: Английский
Citations
3
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(8), P. 2181 - 2198
Published: July 29, 2024
Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo have significant advantages the management ischemic stroke. However, uncertain distribution rapid clearance extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within efficacy may be greatly improved. Furthermore, previous studies indicated that microvesicles, subset large-sized can transport mitochondria to neighboring cells, thereby aiding restoration mitochondrial function post-ischemic Small also demonstrated capability transfer components, such proteins deoxyribonucleic acid, sub-components, vesicle–based therapy. In this review, we undertake comparative analysis isolation techniques employed present an overview current dominant vesicle modification methodologies. Given complex facets treating stroke, delineate various approaches which are suited different treatment process. Moreover, given burgeoning interest delved into feasibility existing research findings transportation fractions intact through small microvesicles offer fresh perspective
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6085 - 6085
Published: May 31, 2024
Endothelial progenitor cells (EPCs) are circulating of various origins that possess the capacity for renewing and regenerating endothelial lining blood vessels. During physical activity, in response to factors such as hypoxia, changes osmotic pressure, mechanical forces, undergo intense physiological stress results damage. Circulating EPCs participate vessel repair vascular healing mainly through paracrine signalling. Furthermore, activity may play an important role mobilising this cell population. In narrative review, we summarise current knowledge on biology EPCs, including their characteristics, assessment, mobilisation both chronic acute healthy individuals.
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 1, 2024
Lung cancer is the major cause of cancer-related deaths worldwide with an estimated 1.8 million and 2.4 new cases in 2022. Poor cardiorespiratory fitness, dyspnea fatigue are common features lung patients, partially limiting exercise prescription. Exercise improves muscular fitness reduces risk some types cancer, including cancer. Recently, American Society Clinical Oncology has encouraged preoperative for patients. Nonetheless, only limited data, mostly obtained from mouse models available on molecular effects Thus, present minireview aims to shed light mechanisms induced by different type In particular, role tumor microenvironment remodeling, angiogenesis, gene expression, apoptosis intermediate metabolism will be examined.
Language: Английский
Citations
0
Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(11)
Published: Nov. 4, 2024
Extracellular vesicles (EVs) are nanoscale released by cells, which play an important role in intercellular communication transporting proteins, lipids, nucleic acids, and other molecules. Different intensities of exercise can induce the release EVs from cells tissues, such as endothelial skeletal muscle adipose tissue, hepatocytes, immune neuronal cells. Exercise-induced exert cardiovascular protective effects anti-inflammatory anti-oxidative altering their contents. This paper reviews cell tissue sources induced different intensities, regulatory on EVs, mechanisms action diseases. The aim is to provide new insights for treatment diseases offer scientific evidence construction engineered mimicking exercise.
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 958, P. 178031 - 178031
Published: Dec. 16, 2024
Language: Английский
Citations
0