Viability and Radiosensitivity of Human Tumor Cells from Breast and Colon Are Influenced by Hypericum perforatum Extract HP01

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 622 - 622

Published: Jan. 13, 2025

To enhance the treatment of tumors that are resistant to radio- and chemotherapy while minimizing side effects radiochemotherapy, researchers continuously seeking new active compounds for use in combination with radiotherapy. Therefore, aim our study was examine cytotoxic radiosensitizing an extract from St. John’s Wort (Hypericum perforatum), referred as HP01, on human epithelial tumor cells vitro. The growth MCF-7 (breast carcinoma) HT-29 (colon examined under influence HP01. In radiation, HP01 cytotoxicity long-term survival were assessed using a colony formation assay. number DNA double-strand breaks analyzed γH2AX assay, cell cycle distribution via flow cytometry. A growth-inhibiting effect observed both lines starting at concentration 10 µg/mL Treatment resulted inhibition clonogenic after ionizing radiation (6 Gy). (DSBs) increased treatment, but repair radiation-induced DSBs not affected. Cell analysis revealed addition enhanced G2/M arrest cells. Overall, only showed also demonstrated first time. We conclude HP01-induced accumulation may be main rationale drug-induced radiosensitivity. It is therefore promising candidate combined therapy diseases warrants further investigation.

Language: Английский

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Transannular Acylation Facilitates C₅–C₉ Bond Formation in Hyperforin Total Synthesis

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Hyperforin is considered the flagship congener among polycyclic polyprenylated acylphloroglucinols due to its compelling and complex molecular architecture, coupled with remarkable biological activity, thus rendering it an appealing synthetic target for chemists over past two decades. Herein, innovative linear total synthesis of hyperforin reported. Our relies on formation bicyclo[3.3.1]nonane-2,4,9-trione framework via transannular acylation a decorated eight-membered ring, followed by late stage bridgehead substitution.

Language: Английский

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New Prospects of Alternative Medicine from Plant Sources in Management of Alzheimer’s Disease

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Although the cure for Alzheimer’s disease (AD) remains elusive, scientific community has remained vigilant in search of remedies AD management. The statistics fight against paint a pale picture; number people suffering from high. About 40 million worldwide, mainly elderly, are experiencing and is expected to rise next decade. Meanwhile, FDA-certified drugs management only relieve symptoms provide limited benefit cognitive functioning patient. increasing economic social burden as well drawbacks current measures highlights need urgent attention alternative avenues combat AD. A major area focus this endeavour herbal therapy. Universally, humanity appreciably recognizes role medicines have played catering human health. Presently, 80% global populace relies on plant-based primary healthcare. Numerous preparations been reported exhibit anti-AD efficacy various research models. This chapter provides an account pathophysiology with study models: clinical trials, vivo, vitro silico.

Language: Английский

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