Pilot Study of Acute and Subchronic Oral Toxicological Biosafety Evaluation of Resorcinol‐Formaldehyde Aerogel Nanomaterial in Kunming Mice DOI Open Access

Guangzhen Zheng,

Yong Zhu,

Bingmin Wu

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Resorcinol-formaldehyde aerogel (RFa) is a unique nanomaterial composed of polymer nanoparticles with three-dimensional network structure. Our previous studies have demonstrated its application in the separation and purification alkaloids, we are exploring potential as drug delivery carrier. Therefore, it necessary to comprehensively understand vivo toxicity profile RFa evaluate oral biosafety. In this work, systematically evaluated acute subchronic both male female Kunming mice. During 14-day test, dose administered (M = 580 mg/kg) was converted from clinical adsorbed alkaloids on RFa. The mice were gavaged only once observed continuously for 14 days. There no abnormalities, pathological changes major organs (heart, liver, spleen, lungs, kidneys, testes, ovaries) detected, followed by 12-week test at 1/4M, 1/2M, M. All orally daily regularly throughout experimental period. As result, abnormalities found body weights, food intake, organ coefficients. Tissue section revealed organs. addition, there significant differences hematological, blood biochemical, coagulation parameters compared control group. These results showed that well tolerated these dosage levels did not cause toxic effects This study, part broad research program biosafety nanomaterials, provided assurance subsequent study biomedical applications.

Language: Английский

Recent progress in two-response signaling aptasensors: Efficient detection tools for various targets DOI
Abouzar Shafaghi, Zahra Khoshbin, Fatemeh Mohammadi

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112643 - 112643

Published: Jan. 2, 2025

Language: Английский

Citations

1

Hydrophobic Silk Fibroin–Agarose Composite Aerogel Fibers with Elasticity for Thermal Insulation Applications DOI Creative Commons

Yuxiang Du,

Pengjie Jiang, Xin Yang

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 266 - 266

Published: April 15, 2024

Aerogel fibers, characterized by their ultra-low density and thermal conductivity, are an ideal candidate for personal management as they hold the potential to effectively reduce energy consumption of room heating significantly contribute conservation. However, most aerogel fibers have weak mechanical properties or require complex manufacturing processes. In this study, simple continuous silk fibroin–agarose composite (SCAFs) were prepared mixing agarose with fibroin through wet spinning rapid gelation, followed solvent replacement supercritical carbon dioxide treatment. Among them, gelation SCAFs was achieved using physical methods heat-reversible gel properties, simplifying preparation process. Hydrophobic (HSCAFs) a chemical vapor deposition (CVD) method. After CVD, HSCAFs’ skeletons uniformly coated silica layer containing methyl groups, endowing them outstanding radial elasticity. Moreover, HSCAFs exhibited low (≤0.153 g/cm3), large specific surface area (≥254.0 m2/g), high porosity (91.1–94.7%), excellent hydrophobicity (a water contact angle 136.8°). More importantly, showed insulation performance in low-temperature (−60 °C) high-temperature (140 environments. The designed may provide new approach high-performance management.

Language: Английский

Citations

4

Preparation of high temperature-resistant alumina-based aerogels and application of high temperature insulation DOI
Hao Ling, Yalong Liao, Lijun Hu

et al.

Journal of the Textile Institute, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Feb. 21, 2025

Language: Английский

Citations

0

Aerogels and Their Composites for Sensing Applications DOI
Abel Inobeme, Stanley Okonkwo, Charles Oluwaseun Adetunji

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 63 - 94

Published: March 14, 2025

Aerogels have garnered significant attention in recent years owing to their unique properties, such as ultra-low density, high surface area, and excellent thermal insulation. These characteristics make aerogels promising candidates for various applications, including sensing. This work presents a comprehensive review of composites utilized sensing applications. We discuss the synthesis methods functionalization techniques tailor properties. Recent advancements development aerogel-based sensors detecting analytes are also discussed. Overall, hold great potential advancing technologies diverse fields ranging from environmental monitoring biomedical diagnostics.

Language: Английский

Citations

0

Physicochemical Properties and Types of Aerogels DOI

Abel Inobeme,

Chetna C. Chauhan, Muniratu Maliki

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 229 - 262

Published: March 14, 2025

Aerogels are a class of materials known for their exceptional physical properties, characterized by high porosity and low density. They composed network interconnected nanoparticles or polymers, resulting in solid with porous structure filled gas. This unique imparts several advantageous physicochemical properties to aerogels, including surface area, thermal conductivity, porosity. These make aerogels promising candidates various applications, such as insulation, catalysis, drug delivery, environmental remediation. chapter focuses on the types aerogels.

Language: Английский

Citations

0

Exploring Future Perspectives in Aerogel-Based Research DOI
John Tsado Mathew,

Musah Monday,

Yakubu Azeh

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 203 - 228

Published: March 14, 2025

Aerogels, with their exceptional properties including ultra-low density, high surface area, and superior thermal insulation, have garnered significant attention across various fields of research application. In this abstract, we delve into the future perspectives aerogel-based research, highlighting emerging trends potential directions. One promising avenue is advancement aerogel manufacturing techniques, aiming for scalability, cost-effectiveness, environmental sustainability. Additionally, integration aerogels novel applications such as energy storage, catalysis, biomedical devices presents exciting opportunities innovation. Furthermore, exploring in like aerospace, wearable technology, remediation holds promise transformative breakthroughs. This abstract provides a glimpse landscape emphasizing importance continued exploration innovation harnessing remarkable these materials

Language: Английский

Citations

0

Biomedical Applications of Aerogel DOI
Stanley Okonkwo, Abel Inobeme, Daniel Ojochenemi Apeh

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 119 - 146

Published: March 14, 2025

Aerogels have garnered significant attention in biomedical applications due to their unique properties. This review explores three key areas: biosensing, imaging, and bone regeneration. In aerogels serve as excellent platforms for immobilizing biomolecules, enabling sensitive detection of analytes through various mechanisms such fluorescence or surface plasmon resonance. low density high area make promising candidates contrast agents drug delivery vehicles magnetic resonance imaging computed tomography. Furthermore, biocompatibility tunable porosity render suitable scaffolds regeneration, promoting cell adhesion, proliferation, mineralization. abstract underscores the multifaceted roles play addressing diverse challenges, paving way future breakthroughs healthcare.

Language: Английский

Citations

0

Sugarcane bagasse-derived silica/carbon composite electrode for tetracycline detection DOI

Roberta Anjos de Jesus,

Gustavo Vicente de Sá Santos,

Giancarlo R. Salazar‐Banda

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 131028 - 131028

Published: May 1, 2025

Citations

0

Biomedical applications of three-dimensional graphene derived nanocomposites DOI
Ayesha Kausar

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 225 - 242

Published: Jan. 1, 2025

Language: Английский

Citations

0

Emerging Trend of Carbon Aerogel Synthesis for Biomedical Applications DOI
Sahar Kiani, Arnab Dutta, Sheng Yong

et al.

Current Opinion in Green and Sustainable Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 101033 - 101033

Published: May 1, 2025

Language: Английский

Citations

0