Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks DOI Creative Commons
Felix Siebenhühner, J. Matias Palva, Satu Palva

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111111 - 111111

Published: Oct. 9, 2024

Neuronal oscillations are ubiquitous in brain activity at all scales and their synchronization dynamics essential for information processing neuronal systems. The underlying synaptic mechanisms, while mainly based on GABA- glutamatergic neurotransmission, influenced by neuromodulatory systems that have highly variable densities of neurotransmitter receptors transporters across the cortical mantle. How they constrain network structures interacting has remained a central unaddressed question. We asked here whether receptor transporter covary with frequency-specific neuroanatomical patterns inter-areal phase synchrony (PS) amplitude correlation (AC) networks resting-state magnetoencephalography (MEG) data. Network centrality delta gamma frequencies covaried positively GABA-, NMDA-, dopaminergic-, most serotonergic covariance was negative alpha beta bands. These results show local microarchitecture shapes macro-scale oscillation spectrally specific patterns.

Language: Английский

GABAB Receptors: Molecular Organization, Function, and Alternative Drug Development by Targeting Protein-Protein Interactions DOI
Dietmar Benke, Musadiq A. Bhat, Mohammad Hleihil

et al.

˜The œReceptors, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 39

Published: Jan. 1, 2024

Language: Английский

Citations

1
Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks DOI Creative Commons
Felix Siebenhühner, J. Matias Palva, Satu Palva

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111111 - 111111

Published: Oct. 9, 2024

Neuronal oscillations are ubiquitous in brain activity at all scales and their synchronization dynamics essential for information processing neuronal systems. The underlying synaptic mechanisms, while mainly based on GABA- glutamatergic neurotransmission, influenced by neuromodulatory systems that have highly variable densities of neurotransmitter receptors transporters across the cortical mantle. How they constrain network structures interacting has remained a central unaddressed question. We asked here whether receptor transporter covary with frequency-specific neuroanatomical patterns inter-areal phase synchrony (PS) amplitude correlation (AC) networks resting-state magnetoencephalography (MEG) data. Network centrality delta gamma frequencies covaried positively GABA-, NMDA-, dopaminergic-, most serotonergic covariance was negative alpha beta bands. These results show local microarchitecture shapes macro-scale oscillation spectrally specific patterns.

Language: Английский

Citations

0