Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 524 - 524
Published: April 3, 2025
Molecular
modelling
is
a
vital
tool
in
the
discovery
and
characterisation
of
bioactive
peptides,
providing
insights
into
their
structural
properties
interactions
with
biological
targets.
Many
models
predicting
peptide
function
or
structure
rely
on
intrinsic
properties,
including
influence
amino
acid
composition,
sequence,
chain
length,
which
impact
stability,
folding,
aggregation,
target
interaction.
Homology
predicts
structures
based
known
templates.
Peptide-protein
can
be
explored
using
molecular
docking
techniques,
but
there
are
challenges
related
to
inherent
flexibility
addressed
by
more
computationally
intensive
approaches
that
consider
movement
over
time,
called
dynamics
(MD).
Virtual
screening
many
usually
against
single
target,
enables
rapid
identification
potential
peptides
from
large
libraries,
typically
approaches.
The
integration
artificial
intelligence
(AI)
has
transformed
leveraging
amounts
data.
AlphaFold
general
protein
prediction
deep
learning
greatly
improved
predictions
conformations
interactions,
addition
estimates
model
accuracy
at
each
residue
guide
interpretation.
Peptide
being
further
enhanced
Protein
Language
Models
(PLMs),
deep-learning-derived
statistical
learn
computer
representations
useful
identify
fundamental
patterns
proteins.
Recent
methodological
developments
discussed
context
canonical
as
well
those
modifications
cyclisations.
In
designing
therapeutics,
main
outstanding
challenge
for
these
methods
incorporation
diverse
non-canonical
acids
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(3), P. 566 - 566
Published: March 2, 2025
The
global
nutraceutical
industry
is
experiencing
a
paradigm
shift,
driven
by
an
increasing
demand
for
functional
foods
and
dietary
supplements
that
address
malnutrition
chronic
diseases
such
as
obesity,
diabetes,
cardiovascular
conditions,
cancer.
Traditional
plant-
animal-derived
nutraceuticals
face
limitations
in
scalability,
cost,
environmental
impact,
paving
the
way
microbial
biotechnology
sustainable
alternative.
Microbial
cells
act
bio-factories,
converting
nutrients
like
glucose
amino
acids
into
valuable
products
polyunsaturated
fatty
(PUFAs),
peptides,
other
bioactive
compounds.
By
harnessing
their
natural
metabolic
capabilities,
microorganisms
efficiently
synthesize
these
compounds,
making
production
effective
approach
development.
This
review
explores
transformative
role
of
platforms
nutraceuticals,
emphasizing
advanced
fermentation
techniques,
synthetic
biology,
engineering.
It
addresses
challenges
optimizing
strains,
ensuring
product
quality,
scaling
while
navigating
regulatory
frameworks.
Furthermore,
highlights
cutting-edge
technologies
CRISPR/Cas9
genome
editing,
adaptive
evolution
strain
enhancement,
bioreactor
innovations
to
enhance
yield
efficiency.
With
focus
on
sustainability
precision,
positioned
game-changer
industry,
offering
eco-friendly
scalable
solutions
meet
health
needs.
integration
omics
exploration
novel
sources
hold
potential
revolutionize
this
field,
aligning
with
growing
consumer
innovative
products.
Foods,
Journal Year:
2024,
Volume and Issue:
13(17), P. 2778 - 2778
Published: Aug. 30, 2024
This
study
aimed
to
establish
the
preparation
process
of
peptide–calcium
chelates
(TMP-Ca)
using
skipjack
tuna
meat
and
investigate
function
mechanism
TMP-Ca
in
an
osteoporosis
model
rats.
The
results
indicated
that
trypsin
is
more
suitable
for
preparing
Ca-chelating
hydrolysates
meat,
optimal
hydrolysis
conditions
were
derived
as
follows:
digestion
time
4
h,
material–liquid
ratio
1:10,
enzyme
dose
3%.
chelating
Ca
with
hydrolysate
optimized
be
chelation
50
min,
temperature
°C,
pH
8.0,
a
peptide–Ca
1:10.
prepared
was
subjected
ultrafiltration,
fraction
(TMP)
(MW
<1
kDa)
showed
highest
rate
(51.27
±
1.42%)
made
into
(TMP-Ca).
In
osteoporotic
rats,
significantly
improved
decrease
ovarian
indexes
caused
by
retinoic
acid.
It
also
elevated
serum
Ca,
phosphorus,
bone
turnover
indexes,
increased
number
trabeculae,
microstructure.
addition,
we
confirmed
could
regulate
OPG/TRAF6
pathway
reduce
osteoclast
differentiation,
inhibit
resorption,
promote
formation.
Therefore,
ameliorate
osteoporosis,
this
provides
functional
component
healthcare
products
treat
osteoporosis.
Foods,
Journal Year:
2025,
Volume and Issue:
14(2), P. 252 - 252
Published: Jan. 14, 2025
The
impact
of
the
world’s
growing
population
on
food
systems
and
role
dietary
patterns
in
management
non-communicable
diseases
underscore
need
to
explore
sustainable
protein
sources.
Although
microalgae
have
stood
out
as
alternative
sources
proteins
bioactive
peptides,
some
species
such
Nannochloropsis
gaditana
remain
unexplored.
This
study
aimed
characterize
N.
gaditana’s
proteome
evaluate
its
potential
a
source
peptides
by
using
an
silico
approach.
A
total
1955
were
identified
classified
into
functional
groups
cellular
components,
molecular
functions,
biological
processes.
In
gastrointestinal
digestion
demonstrated
that
202
hydrophobic
low-molecular-size
with
bioactivity
released.
Among
them,
27
exhibited
theorical
antioxidant,
antihypertensive,
antidiabetic,
anti-inflammatory,
and/or
antimicrobial
activities.
Seven
twenty-seven
showed
≥20%
intestinal
absorption,
suggesting
systemic
effects,
while
rest
could
act
at
local
level.
Molecular
docking
strong
affinities
key
enzymes
MPO,
ACE,
DPPIV.
Resistance
digestion,
capacity
be
absorbed,
multifunctionality
for
peptide
FIPGL.
highlights
novel
promising
effects.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5333 - 5333
Published: May 14, 2024
Mulberry
is
a
rapidly
growing
plant
that
thrives
in
diverse
climatic,
topographical,
and
soil
types,
spanning
temperature
temperate
countries.
plants
are
valued
as
functional
foods
for
their
abundant
chemical
composition,
serving
significant
reservoir
of
bioactive
compounds
like
proteins,
polysaccharides,
phenolics,
flavonoids.
Moreover,
these
displayed
potent
antioxidant
activity
by
scavenging
free
radicals,
inhibiting
reactive
oxygen
species
generation,
restoring
elevated
nitric
oxide
production
induced
LPS
stimulation
through
the
downregulation
inducible
NO
synthase
expression.
Active
components
oxyresveratrol
found
Foods,
Journal Year:
2024,
Volume and Issue:
13(21), P. 3369 - 3369
Published: Oct. 23, 2024
Microbial
fermentation
is
a
well-known
strategy
for
enhancing
the
nutraceutical
attributes
of
foods.
Among
outcomes,
bioactive
peptides
(BAPs),
short
chains
amino
acids
resulting
from
proteolytic
activity,
are
emerging
as
promising
components
thanks
to
their
bioactivities.
Indeed,
BAPs
offer
numerous
health
benefits,
including
antimicrobial,
antioxidant,
antihypertensive,
and
anti-inflammatory
properties.
This
review
focuses
on
production
during
process,
emphasizing
how
different
microbial
strains
conditions
influence
quantity
quality
these
peptides.
Furthermore,
it
examines
benefits
fermented
foods,
highlighting
potential
in
disease
prevention
overall
promotion.
Additionally,
this
addresses
challenges
future
directions
field.
comprehensive
overview
underscores
promise
foods
sustainable
potent
sources
peptides,
with
significant
implications
developing
functional
nutraceuticals.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 23, 2024
Inflammation
is
a
normal
immune
response
in
organisms,
but
it
often
triggers
chronic
diseases
such
as
colitis
and
arthritis.
Currently,
the
most
widely
used
anti-inflammatory
drugs
are
non-steroidal
drugs,
albeit
they
accompanied
by
various
adverse
effects
hypertension
renal
dysfunction.
Bioactive
peptides
(BAPs)
provide
therapeutic
benefits
for
inflammation
mitigate
side
effects.
Herein,
this
review
focuses
on
of
BAPs
different
body
parts.
Emphasis
placed
immunomodulatory
mechanisms
treating
inflammation,
regulating
release
inflammatory
mediators,
modulating
MAPK
NF-κB
signaling
pathways,
reducing
oxidative
stress
reactions
immunomodulation.
This
aims
to
reference
function,
application,
anti-inflammation
BAPs.
Fermentation,
Journal Year:
2025,
Volume and Issue:
11(1), P. 36 - 36
Published: Jan. 17, 2025
The
article
reviews
the
literature
on
antimicrobial
peptides
(AMPs)
that
exhibit
unique
mechanisms,
such
as
broad-spectrum
activity,
low
development
of
resistance,
and
ability
to
modulate
immune
response
host
organism.
Information
is
provided
significant
potential
AMPs
in
fight
against
pathogens
threatening
human
health
food
safety.
Enrichment
diet
with
biologically
active
obtained
using
proteolytic
activity
lactic
acid
bacteria
(LAB)
proposed
a
simple,
accessible,
viable
alternative
antibiotics
does
not
have
harmful
side
effect.
review
briefly
covers
methods
for
obtaining
features
LAB
system
responsible
producing
bioactive
environment.
It
has
been
shown
various
strains
makes
it
possible
produce
high-quality
whey-based
beverages
different
directions
antagonistic
opportunistic
helps
optimize
gastrointestinal
microbiota.
assumed
drinks
can
reduce
dose
antimicrobials
combined
therapy
infectious
diseases
be
preventive
measure
contagion
spread
resistance.
