Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance DOI
Е. Л. Паткин, И. О. Сучкова, Sergey G. Tsikunov

et al.

Успехи физиологических наук, Journal Year: 2024, Volume and Issue: 55(4), P. 3 - 26

Published: Dec. 8, 2024

Post-traumatic stress disorder is a mental that closely associated with dysfunction of the hypothalamic-pituitary-adrenal axis, and for its development required experience traumatic event causes negative emotions memories persist quite long time. The likelihood post-traumatic influenced both environmental factors, genetic epigenetic characteristics body. In this case modifications act as dynamic biomarkers (“nanotags”) impact environment on genome (epigenome), which can, under certain conditions, disappear or remain not only in an individual directly exposed to psychogenic trauma, but also transmitted over number generations. Review focuses possible mechanisms intergenerational transgenerational inheritance biological effects stress-related disorders.

Language: Английский

LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review DOI

Shayan Khalilollah,

Sina Kalantari Soltanieh,

Raed Obaid Saleh

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 179, P. 156585 - 156585

Published: April 4, 2024

Language: Английский

Citations

3
Potential Correlation Between Molecular Biomarkers and Oxidative Stress in Traumatic Brain Injury DOI Open Access
Cătălina Ionescu,

Madalina Ghidersa,

Alin Ciobîcă

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3858 - 3858

Published: April 18, 2025

Diagnosing traumatic brain injury (TBI) remains challenging due to an incomplete understanding of its neuropathological mechanisms. TBI is recognised as a complex condition involving both primary and secondary injuries. Although oxidative stress non-specific molecular phenomenon observed in various conditions, it plays crucial role response recovery. Due these aspects, we aimed evaluate the interaction between some known biomarkers providing evidence for possible relevance clinical diagnosis outcome prediction. We found that while many currently validated interact with pathways, their patterns variation could assist diagnosis, prognosis, outcomes prediction cases.

Language: Английский

Citations

0
Decoding serotonin: the molecular symphony behind depression DOI Creative Commons

Yue Shu,

Lei Tian, Xing Wang

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 24, 2025

The serotonin (5-hydroxytryptamine) system represents a crucial neurotransmitter network that regulates mood, behavior, and cognitive functions, playing significant role in the pathogenesis progression of depression. Although this perspective faces challenges, continues to exert substantial modulatory effects on specific aspects psychological functioning actively contributes multiple pathological processes depression development. Therefore, review systematically integrates interdisciplinary research advances regarding relationship between 5-hydroxytryptamine (5-HT) By focusing core biological including biosynthesis metabolism, SERT gene regulatory networks, protein molecular modifications, it aims elucidate how 5-HT dysregulation development depression, while providing novel perspectives therapeutic targets for innovative antidepressant drug

Language: Английский

Citations

0
Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders DOI
Bhaskar Roy,

Anuj Kumar Verma,

Ellie Marie Hulwi

et al.

Genomic psychiatry :, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: July 18, 2024

Unipolar and bipolar depression [major depressive disorder (MDD) (BD)] are complex psychiatric disorders characterized by disturbances in mood, affect, cognition. Increasing evidence has confirmed epigenetic malfunctioning at the core of these two mental conditions; however, exact molecular nature that maladaptivity is less known. Lately, long noncoding RNAs (lncRNAs) have emerged as essential regulators gene expression cellular processes, offering new avenues for exploring pathophysiology mood disorders. In this report, we present a comprehensive review recent clinical studies investigating involvement lncRNA MDD BD, emphasizing their disease-specific contribution potential biomarkers. We explore dysregulation specific lncRNAs detected peripheral blood samples individuals with disorders, while underscoring significance diagnosis, prognosis, predicting treatment response. Additionally, provide future directions research context

Language: Английский

Citations

1
Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury DOI
Zhiqiang Tang, Shuyun Xu,

Shucheng Zhao

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2024, Volume and Issue: 249, P. 108648 - 108648

Published: Nov. 19, 2024

Language: Английский

Citations

1
Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes DOI Creative Commons
Shuang Liang,

Zihui Hu

Biomedical Papers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Traumatic brain injury (TBI) has long-term consequences, including neurodegenerative disease risk. Current diagnostic tools are limited in detecting subtle damage. This review explores emerging biomarkers for TBI, those related to neuronal injury, inflammation, EVs, and ncRNAs, evaluating their potential predict clinical outcomes like mortality, recovery, cognitive impairment. It addresses challenges opportunities implementing practice, aiming improve TBI diagnosis, prognosis, treatment.

Language: Английский

Citations

0
Post-traumatic stress disorder: molecular mechanisms of the intergenerational and transgenerational inheritance DOI
Е. Л. Паткин, И. О. Сучкова, Sergey G. Tsikunov

et al.

Успехи физиологических наук, Journal Year: 2024, Volume and Issue: 55(4), P. 3 - 26

Published: Dec. 8, 2024

Post-traumatic stress disorder is a mental that closely associated with dysfunction of the hypothalamic-pituitary-adrenal axis, and for its development required experience traumatic event causes negative emotions memories persist quite long time. The likelihood post-traumatic influenced both environmental factors, genetic epigenetic characteristics body. In this case modifications act as dynamic biomarkers (“nanotags”) impact environment on genome (epigenome), which can, under certain conditions, disappear or remain not only in an individual directly exposed to psychogenic trauma, but also transmitted over number generations. Review focuses possible mechanisms intergenerational transgenerational inheritance biological effects stress-related disorders.

Language: Английский

Citations

0