Physico-Chemical Characterization and Initial Evaluation of Carboxymethyl Chitosan–Hyaluronan Hydrocolloid Systems with Insulin Intended for Intranasal Administration DOI Open Access
Roxana Popescu, Cristina-Elena Dinu-Pîrvu, Mihaela Violeta Ghica

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10452 - 10452

Published: Sept. 27, 2024

The nasal route of administration can bypass the blood-brain barrier in order to obtain a higher concentration brain, thus offering feasible alternative for diseases associated with central nervous system. advantages intranasal and potential favorable therapeutic effects intranasally administered insulin led formulation carboxymethyl chitosan (CMC) sodium hyaluronate (NaHA) hydrocolloidal systems administration, targeting nose-to-brain delivery initial assessment these systems. influence variables on response parameters defined as surface properties, rheology, vitro release were analyzed using experimental design statistical programs (Modde Minitab software). recorded good wetting adhesion capacity, allowing spread mucosa. samples had pseudoplastic flow rapid was according our objective. According physico-chemical characterization preliminary assessment, formulations are appropriate mucosa, but further studies necessary demonstrate beneficial actions safety insulin.

Language: Английский

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI Open Access

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

Citations

15
Neural Networks and Chemical Messengers: Insights into Tobacco Addiction DOI

Jieping Sun,

Qingqing Lv, Jinghan Dang

et al.

Brain Topography, Journal Year: 2025, Volume and Issue: 38(4)

Published: May 13, 2025

Language: Английский

Citations

0
Physico-Chemical Characterization and Initial Evaluation of Carboxymethyl Chitosan–Hyaluronan Hydrocolloid Systems with Insulin Intended for Intranasal Administration DOI Open Access
Roxana Popescu, Cristina-Elena Dinu-Pîrvu, Mihaela Violeta Ghica

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10452 - 10452

Published: Sept. 27, 2024

The nasal route of administration can bypass the blood-brain barrier in order to obtain a higher concentration brain, thus offering feasible alternative for diseases associated with central nervous system. advantages intranasal and potential favorable therapeutic effects intranasally administered insulin led formulation carboxymethyl chitosan (CMC) sodium hyaluronate (NaHA) hydrocolloidal systems administration, targeting nose-to-brain delivery initial assessment these systems. influence variables on response parameters defined as surface properties, rheology, vitro release were analyzed using experimental design statistical programs (Modde Minitab software). recorded good wetting adhesion capacity, allowing spread mucosa. samples had pseudoplastic flow rapid was according our objective. According physico-chemical characterization preliminary assessment, formulations are appropriate mucosa, but further studies necessary demonstrate beneficial actions safety insulin.

Language: Английский

Citations

0