Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

The intestinal wall is a selectively permeable barrier between the content of lumen and internal environment body. Disturbances permeability can potentially lead to unwanted activation enteric immune system due excessive contact with gut microbiota its components, development endotoxemia, when level bacterial lipopolysaccharides increases in blood, causing chronic low-intensity inflammation. In this review, following aspects are covered: structure barrier; influence on via regulation functioning tight junction proteins, synthesis/degradation mucus antioxidant effects; molecular mechanisms pro-inflammatory response caused by invasion through TLR4-induced TIRAP/MyD88 TRAM/TRIF signaling cascades; nutrition permeability, exercise an emphasis exercise-induced heat stress hypoxia. Overall, review provides some insight into how prevent associated inflammatory processes involved many if not most pathologies. Some diets physical supposed be non-pharmacological approaches maintain integrity function provide efficient operation. However, at early age, increased has hormetic effect contributes system.

Language: Английский

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Barrier-Strengthening Effects of Cannabidiol on Porcine Peyer’s Patches

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3360 - 3360

Published: April 3, 2025

Cannabidiol (CBD), a major non-psychoactive cannabinoid of the Cannabis sativa L. plant, has demonstrated anti-inflammatory effects in various studies. However, therapeutic use CBD is still limited. Despite its potential, little known about molecular mechanisms on epithelial integrity, particularly concerning native intestinal tissue. To accomplish this, our study aimed to investigate ex vivo follicle-associated epithelium Peyer's Patches (PP) and villus (VE) from porcine intestine. measure barrier, Ussing chamber technique was employed, followed by immunoblotting confocal laser-scanning immunofluorescence microscopy tight junction proteins specific receptors. The results revealed that significantly strengthens barrier PP upregulation sealing proteins, including occludin, claudin-1, -3, -7. Additionally, showed potential decrease expression Tumor necrosis factor alpha (TNFɑ) receptor 1 (TNFR-1) plays key role chronic inflammatory diseases. highlights prevention conditions underlines important as target for bioactive compounds.

Language: Английский

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Enhancing intestinal tight junction assembly by gallic acid as a subcellular basis for the pharmacological effect of Ocimum sanctum L. flower aqueous extract

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106519 - 106519

Published: Nov. 1, 2024

Language: Английский

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Protective Capacity of Helichrysum italicum Infusion Against Intestinal Barrier Disruption and Translocation of Salmonella Infantis

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1398 - 1398

Published: Oct. 19, 2024

is a Mediterranean plant with well-known anti-inflammatory activity, but our previous whole transcriptome analysis has found that

Language: Английский

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Co-Digestion of Tea Extracts with Omega-3 Fatty Acids Enhances Digestive Stability and Intestinal Absorption of Omega-3 Fatty Acids by Increasing Antioxidant Activity and Micelle Stabilization

Applied Sciences, Journal Year: 2024, Volume and Issue: 15(1), P. 233 - 233

Published: Dec. 30, 2024

The current study hypothesized that omega-3 fatty acids ω-3 FAs consumed with various tea extracts, which included green extract comprising 35% and 65% catechin (GTE35 GTE65), naturally fermented (Heukcha) (NFGT), a complex of heat-treated enzymatically-modified isoquercitrin (1:1, w:w) (AdiphenonTM) would enhance the digestive stability intestinal absorption FAs. eicosapentaenoic acid (EPA) docosahexaenoic (DHA) co-digested GTE65 using an in vitro digestion model system was improved by up to 20.76% 23.22%, respectively, compared oxidative stability, measured peroxide values, lowest, whereas DPPH radical scavenging capacity during highest Adiphenon™, showing 1.03 ± 0.25 meq O2/kg oil 1251.96 26.03 µmol TE/g. deviation zeta potential reduced when were co-treated indicating micelle is stable. Caco-2 cells increased 34.53% for EPA 60.23% DHA extracts alone. co-treatment GTE35 Adiphenon™ did not alter expression P-glycoprotein (P-gp) alone, implies efflux polyphenols, such as catechins, could be limited due suppression P-gp FA. results from suggest co-intake increase bioavailability preventing oxidation, stabilizing structures, minimizing efflux.

Language: Английский

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Special Issue “The Tight Junction and Its Proteins: From Structure to Pathologies”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13154 - 13154

Published: Dec. 7, 2024

Most tight junction (TJ) proteins build epithelial and endothelial barriers [...].

Language: Английский

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