Natural Product Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Dec. 30, 2024
An
undescribed
cladosporol
derivative
named
cladosporine
(1),
together
with
eight
known
compounds
(2-9)
were
characterised
from
Cladosporium
colombiae
GTJ67,
an
endophytic
fungus
Aconitum
hemsleyanum.
Their
structures
established
by
detailed
analysis
of
the
spectroscopic
data,
HRESIMS,
NMR
calculations
DP4+
probability
analyses
and
ECD
spectra.
Compounds
3
5
exhibited
inhibitory
activity
against
Candida
albicans
MIC
values
1
μg/mL
4
respectively,
compound
6
Staphylococcus
aureus
value
μg/mL.
Journal of Fungi,
Journal Year:
2025,
Volume and Issue:
11(2), P. 113 - 113
Published: Feb. 3, 2025
(1)
Background:
Endophytic
fungi
play
an
important
role
in
plant
growth
and
stress
resistance.
The
presence
of
a
special
fungal
taxon
such
as
the
dark
septate
endophytic
(DSE)
alpine
environments
is
particularly
for
resistance
to
environmental
stresses.
However,
composition
root
different
between
host
plants
has
not
been
well
studied.
(2)
Results:
A
total
408
culturable
were
isolated
from
roots
Saussurea
involucrata
Rhodiola
crenulata
which
collected
5
plots
Tianshan
Karakoram
Mountains
Xinjiang
region,
belonging
91
species,
54
genera,
31
families,
3
phyla
based
on
morphological
characteristics
molecular
sequence.
Among
them,
DSE
dominant
group,
accounting
52.94%,
Leptodontidium
orchidicola
was
species.
In
addition,
we
also
compared
diversity
sites,
with
emphasis
taxa
DSE.
(3)
Conclusions:
cultural
are
significantly
two
medicinal
species
across
various
locations.
Some
showed
preferences
or
environment.
resources,
especially
DSE,
very
rich
plants,
indicating
that
these
may
crucial
ecological
adaptation
harsh
environments.
Marine Drugs,
Journal Year:
2025,
Volume and Issue:
23(3), P. 115 - 115
Published: March 7, 2025
Marine
microplastics
(MPs)
represent
a
novel
ecological
niche,
populated
by
fungi
with
high
potential
for
pharmaceutical
discovery.
This
study
explores
the
bioactivity
of
fungal
strains
isolated
from
MPs
in
Mediterranean
sediments,
focusing
on
their
osteogenic
and
antiviral
activities.
Crude
extracts
prepared
via
solid-state
submerged-state
fermentation
were
tested
effects
extracellular
matrix
mineralization
vitro
bone
growth
zebrafish
larvae,
activity
against
respiratory
syncytial
virus
(RSV)
herpes
simplex
type
2
(HSV-2).
Several
exhibited
significant
mineralogenic
activities,
Aspergillus
jensenii
MUT6581
Cladosporium
halotolerans
MUT6558
being
most
performing
ones.
Antiviral
assays
identified
A.
Bjerkandera
adusta
MUT6589
as
effective
RSV
HSV-2
at
different
extents,
no
cytotoxic
effect.
Although
chemical
profiling
extract
led
to
isolation
decumbenones
A
B,
they
did
not
reproduce
observed
bioactivities,
suggesting
involvement
other
active
compounds
or
synergistic
effects.
These
results
highlight
plastisphere
valuable
resource
bioactive
suggest
need
further
fractionation
characterization
identify
molecules
responsible
these
promising
Natural Product Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 7
Published: March 17, 2025
A
new
aromatic
diamide
compound,
aspergillusin
(1),
together
with
three
known
compounds,
globosterol
(2),
ergosterol
(3),
and
cladosporide
(4),
was
isolated
from
the
crude
extract
of
endophytic
fungi
Aspergillus
sp.
H30.
The
structures
were
elucidated
using
NMR
MS
data,
finally,
biosynthetic
pathway
compound
1
hypothesised.
Compounds
1–4
tested
for
their
antibacterial
activities
on
six
pathogenic
bacteria
also
evaluated
against
human
non-small
cell
lung
cancer
H1299.
Among
them,
exhibited
weak
activity
MRSA
a
strong
effect
bronchial
epithelial
line,
BEAS-2B,
an
IC50
value
12.32
±
0.37
μM.
Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
4(4), P. 1411 - 1421
Published: Sept. 24, 2024
This
study
explores
the
relationship
between
filamentous
fungi
and
dental
caries
in
isolated
indigenous
communities
Siltepec,
Chiapas,
Mexico.
A
total
of
37
oral
swabs
were
collected,
with
22
participants
harboring
fungi,
primarily
from
genus
Cladosporium.
Statistical
analysis
using
Student’s
t-test
Mann–Whitney
U
test
revealed
a
significant
reduction
extensive
fully
cavitated
(p
<
0.0001)
individuals
while
those
without
exhibited
higher
rates
decay.
Participants
had
prevalence
healthy
teeth
incipient
caries.
The
findings
suggest
that
traditional
maize-based
diets,
particularly
fermented
beverages
like
pozol,
may
promote
growth
beneficial
microbiome,
offering
protective
effect
against
through
microbial
competition
alteration
environment.
These
results
underline
need
for
further
research
into
long-term
impact
diets
on
health
potential
use
natural
substances,
such
as
probiotics
plant-based
antimicrobials,
to
maintain
homeostasis
prevent
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 11, 2024
Introduction
The
marine
environment
is
extremely
complex
and
exerts
strong
evolutionary
pressure
often
leading
to
the
appearance
of
microbial
strains
with
new
metabolic
competencies.
Microorganisms
in
ecosystems
are
still
largely
unknown
should
be
explored
conserved
for
biodiversity
preservation,
possible
ecosystem
restoring,
other
applications.
Biodiversity
conservation
become
a
basic
ecological
strategy
particular
significance
relation
global
change.
In
this
context,
present
research
aimed
at
exploring
culturable
mycobiota
associated
jellyfish
Pelagia
noctiluca,
never
studied
before.
addition,
isolated
were
tested
potential
application
(antimicrobial
activity
presence
genes
related
production
secondary
metabolites).
Methods
Five
jellyfishes
collected
coastal
area
Giglio
Island
processed
isolate
epizoic
fungi.
identified
using
polyphasic
approach
(morphological,
physiological,
molecular)
their
salt
preference
was
also
investigated.
antifungal
antibacterial
each
strain
agar
plug
diffusion
test.
some
key
main
pathways
metabolites
fungi,
polyketide
synthases
(PKSs),
non-ribosomal
peptide
synthase
(NRPSs),
assessed.
Results
A
total
164
isolates
obtained;
after
dereplication,
40
morphotypes,
23
species
identified.
phylogenetic
analyses
suggested
taxa
belonging
Pleosporales:
two
genera
species,
Tamaricicola
.
detected
showed
relatively
high
diversity,
if
compared
fungal
communities.
All
fungi
as
confirmed
by
marked
euryhalinism.
PKSs
NRPSs,
four
nine
strains,
respectively.
antimicrobial
revealed
70%
including
taxa.
abundance
bioactive
may
involvement
host
defense
strategies.
Moreover,
these
could
show
further
biotechnological
applications
particularly
case
maintained
culture
collections.
