Polymers,
Journal Year:
2024,
Volume and Issue:
17(1), P. 7 - 7
Published: Dec. 24, 2024
Methyl
gallate
(MG),
a
natural
phenolic
compound,
exhibits
in
vitro
synergistic
activity
with
amoxicillin
(Amox)
against
methicillin-resistant
Staphylococcus
aureus
(MRSA),
global
health
concern.
This
study
developed
electrospun
nanofibers
incorporating
MG
and
Amox
into
poly(vinyl
alcohol)
(PVA)/chitosan
(CS)
blend
to
target
both
methicillin-susceptible
S.
(MSSA)
MRSA.
The
formulation
was
optimized,
the
impact
of
acetic
acid
on
antibacterial
evaluated
using
agar
disc
diffusion.
final
fabricated
characterized
SEM,
FTIR,
DSC,
swelling,
release
behavior
analyses
understand
its
efficacy.
Results
revealed
that
eliminated
activity,
but
(64
mg/mL)
(2.5
were
successfully
incorporated
PVA/CS
solution
prepared
deionized
water.
resulting
nanofiber
mats
featured
nanoscale
fibers
(126
±
45
nm)
micron-oval
beads.
Despite
synergism,
MG/Amox/PVA/CS
showed
no
significant
improvement
over
or
alone
MRSA,
likely
due
their
physicochemical
properties.
FTIR
DSC
results
confirmed
molecular
interactions
between
active
compounds
polymer
matrix,
which
may
cause
minimal
swelling
low
drug
at
24
h.
offers
insights
potential
MG/Amox-loaded
for
anti-MRSA
material
development.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2021 - 2021
Published: July 15, 2024
Poly(vinyl
alcohol)
(PVA)
is
a
versatile
synthetic
polymer,
used
for
the
design
of
hydrogels,
porous
membranes
and
films.
Its
solubility
in
water,
film-
hydrogel-forming
capabilities,
non-toxicity,
crystallinity
excellent
mechanical
properties,
chemical
inertness
stability
towards
biological
fluids,
superior
oxygen
gas
barrier
good
printability
availability
(relatively
low
production
cost)
are
main
aspects
that
make
PVA
suitable
variety
applications,
from
biomedical
pharmaceutical
uses
to
sensing
devices,
packaging
materials
or
wastewater
treatment.
However,
pure
present
limited
flexibility
poor
biocompatibility
biodegradability,
which
restrict
its
use
alone
various
applications.
mixed
with
other
polymers
biomolecules
(polysaccharides,
proteins,
peptides,
amino
acids
etc.),
as
well
inorganic/organic
compounds,
generates
wide
PVA’s
shortcomings
considerably
improved,
new
functionalities
obtained.
Also,
transformation
brings
features
opens
door
unexpected
uses.
The
review
focused
on
recent
advances
PVA-based
hydrogels.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9524 - 9524
Published: Sept. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Polymers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 230 - 230
Published: Jan. 17, 2025
Our
work
describes
the
green
synthesis
of
silver
sulfide
nanoparticles
(Ag2S
NPs)
and
their
formulation
into
polycaprolactone
fibers
(PCL),
aiming
to
improve
multifunctional
biological
performance
PCL
membranes
as
scaffolds.
For
this
purpose,
an
extract
rosemary
(Salvia
rosmarinus)
was
employed
a
reducing
agent
for
Ag2S
NPs,
obtaining
irregular
NPs
clusters
5-60
nm,
with
characteristic
SPR
absorption
at
369
nm.
successfully
incorporated
by
electrospinning
using
heparin
(HEP)
stabilizer/biocompatibility
agent,
nanostructured
ca.
500-800
nm
diameter.
Different
amounts
(0.05,
0.5,
1
wt.%)
enhanced
membranes'
surface
polarity
mechanical
performance,
controlled
ion
release
after
6
days
submerged
in
PBS
solution,
determined
cyclic
voltammetry.
As
result,
PCL/HEP/Ag2S
scaffolds
exhibit
high
antibacterial
(80-90%)
early
stages
contact
(3
h)
against
E.
coli
S.
aureus.
Also,
cytotoxicity
analysis
demonstrated
that
are
biocompatible
fibroblast
cell
regeneration,
which
is
optimal
application
To
validate
regenerative
response
scaffolds,
wounds
were
induced
Wistar
rats,
presenting
favorable
healing
1%,
compared
untreated
wound.
results
indicated
enable
development
novel
nanomaterials
performance.
