Methyl Gallate and Amoxicillin-Loaded Electrospun Poly(vinyl alcohol)/Chitosan Mats: Impact of Acetic Acid on Their Anti-Staphylococcus aureus Activity DOI Open Access
Pimsumon Jiamboonsri, Weradesh Sangkhun, Sompit Wanwong

et al.

Polymers, Journal Year: 2024, Volume and Issue: 17(1), P. 7 - 7

Published: Dec. 24, 2024

Methyl gallate (MG), a natural phenolic compound, exhibits in vitro synergistic activity with amoxicillin (Amox) against methicillin-resistant Staphylococcus aureus (MRSA), global health concern. This study developed electrospun nanofibers incorporating MG and Amox into poly(vinyl alcohol) (PVA)/chitosan (CS) blend to target both methicillin-susceptible S. (MSSA) MRSA. The formulation was optimized, the impact of acetic acid on antibacterial evaluated using agar disc diffusion. final fabricated characterized SEM, FTIR, DSC, swelling, release behavior analyses understand its efficacy. Results revealed that eliminated activity, but (64 mg/mL) (2.5 were successfully incorporated PVA/CS solution prepared deionized water. resulting nanofiber mats featured nanoscale fibers (126 ± 45 nm) micron-oval beads. Despite synergism, MG/Amox/PVA/CS showed no significant improvement over or alone MRSA, likely due their physicochemical properties. FTIR DSC results confirmed molecular interactions between active compounds polymer matrix, which may cause minimal swelling low drug at 24 h. offers insights potential MG/Amox-loaded for anti-MRSA material development.

Language: Английский

An Approach to Fabricate Biofibers with Spider Weblike Structures Based on Electrospinning Device DOI

O. M. García-Tirado,

W. J. Pech-Rodríguez, P. C. Meléndez-González

et al.

Arabian Journal for Science and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Citations

0
Methyl Gallate and Amoxicillin-Loaded Electrospun Poly(vinyl alcohol)/Chitosan Mats: Impact of Acetic Acid on Their Anti-Staphylococcus aureus Activity DOI Open Access
Pimsumon Jiamboonsri, Weradesh Sangkhun, Sompit Wanwong

et al.

Polymers, Journal Year: 2024, Volume and Issue: 17(1), P. 7 - 7

Published: Dec. 24, 2024

Methyl gallate (MG), a natural phenolic compound, exhibits in vitro synergistic activity with amoxicillin (Amox) against methicillin-resistant Staphylococcus aureus (MRSA), global health concern. This study developed electrospun nanofibers incorporating MG and Amox into poly(vinyl alcohol) (PVA)/chitosan (CS) blend to target both methicillin-susceptible S. (MSSA) MRSA. The formulation was optimized, the impact of acetic acid on antibacterial evaluated using agar disc diffusion. final fabricated characterized SEM, FTIR, DSC, swelling, release behavior analyses understand its efficacy. Results revealed that eliminated activity, but (64 mg/mL) (2.5 were successfully incorporated PVA/CS solution prepared deionized water. resulting nanofiber mats featured nanoscale fibers (126 ± 45 nm) micron-oval beads. Despite synergism, MG/Amox/PVA/CS showed no significant improvement over or alone MRSA, likely due their physicochemical properties. FTIR DSC results confirmed molecular interactions between active compounds polymer matrix, which may cause minimal swelling low drug at 24 h. offers insights potential MG/Amox-loaded for anti-MRSA material development.

Language: Английский

Citations

0