Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Dec. 30, 2024
Language: Английский
Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: 50(5), P. 1067 - 1082
Published: July 2, 2024
Abstract Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic, cognitive, neuroanatomical changes. Recent studies have used optical coherence tomography (OCT) to investigate retinal changes in SZ BD, but their unique shared require further evaluation. Articles were identified using PubMed Google Scholar. 39 met the inclusion criteria. Diagnostic groups proband (SZ/BD combined), SZ, healthy control (HC) eyes. Meta-analyses utilized fixed random effects models when appropriate, publication bias was corrected trim-and-fill analysis (“meta” package R). Results reported as standardized mean differences with 95% CIs. Data from 3145 patient eyes (1956 1189 BD) 3135 HC included. Studies thinning of peripapillary nerve fiber layer (pRNFL, overall 2 subregions), m-Retina (overall all mGCL-IPL, mIPL, mRPE patients. BD showed pRNFL each subregion), pGCC, macular Retina (in 5 no thickness or volume for total retina. Neither nor patients demonstrated significant fovea, mRNFL, mGCL, mGCC, mINL, mOPL, mONL, choroid thicknesses. Moderating age, illness duration, smoking on structures identified. This meta-analysis builds upon previous literature this field incorporating recent OCT examining both regions respect psychotic disorders. Overall, structural abnormalities people compared HCs.
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159618 - 159618
Published: Jan. 15, 2025
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(5)
Published: Jan. 31, 2025
Alzheimer’s disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges affecting more than 30 million people worldwide with etiology still largely enigmatic. The intricate gut-brain axis, serving as vital communication network between gut and brain, appears to wield influence in progression AD. Our study showcases remarkable precision x-ray phase-contrast tomography (XPCT) conducting an advanced three-dimensional examination cellular composition structure. exploitation micro- nano-XPCT on various AD mouse models unveiled relevant alterations villi crypts, transformations Paneth goblet cells, along detection telocytes, neurons, erythrocytes, mucus secretion by cells within cavity. observed structural variations may elucidate transition from dysbiosis neurodegeneration cognitive decline. Leveraging XPCT could prove pivotal early prognosis disease.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 293 - 293
Published: Feb. 21, 2025
Retinal models play a pivotal role in translational drug development, bridging preclinical research and therapeutic applications for both ocular systemic diseases. This review highlights the retina as an ideal organ studying advanced therapies, thanks to its immune privilege, vascular neuronal networks, accessibility, imaging capabilities. Preclinical retinal disease offer unparalleled insights into inflammation, angiogenesis, fibrosis, hypoxia, utilizing clinically translatable bioimaging tools like fundoscopy, optical coherence tomography, confocal scanning laser ophthalmoscopy, fluorescein angiography, optokinetic tracking, electroretinography. These have driven innovations anti-inflammatory, anti-angiogenic, neuroprotective strategies, with broader implications diseases such rheumatoid arthritis, Alzheimer’s, fibrosis-related conditions. By emphasizing integration of 3Rs principles novel modalities, this how not only enhances precision but also minimizes ethical concerns, paving way more predictive human-relevant approaches development.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Abstract In recent years, nanomaterials have demonstrated broad prospects in the diagnosis and treatment of retinal diseases due to their unique physicochemical properties, such as small‐size effects, high biocompatibility, functional surfaces. Retinal are often accompanied by complex pathological microenvironments, where conventional diagnostic therapeutic approaches face challenges low drug delivery efficiency, risks associated with invasive procedures, difficulties real‐time monitoring. Nanomaterials hold promise addressing these limitations traditional therapies, thereby improving precision efficacy. The applications diagnostics summarized, they enable high‐resolution imaging carrying fluorescent probes or contrast agents act biosensors sensitively detect disease‐related biomarkers, facilitating early dynamic therapeutics, functionalized nanocarriers can precisely deliver drugs, genes, antioxidant molecules target cells, significantly enhancing outcomes while reducing systemic toxicity. Additionally, nanofiber materials possess properties that make them particularly suitable for regeneration tissue engineering. By loading neurotrophic factors into scaffolds, regenerative effects be amplified, promoting repair neurons. Despite immense potential, clinical translation still requires long‐term biosafety, scalable manufacturing processes, optimization targeting efficiency.
Language: Английский
Citations
0
NeuroToxicology, Journal Year: 2024, Volume and Issue: 104, P. 36 - 44
Published: July 14, 2024
Ozone (O3) forms in the Earth's atmosphere, both naturally and by reactions of man-made air pollutants. Deleterious effects O3 have been found respiratory system. Here, we examine whether alters olfactory behavior cellular properties For this purpose, mice were exposed to at a concentration highly polluted city [0.8 ppm], elicited social non-social odors habituation/dishabituation tests was assessed. In addition, electrical responses dopaminergic bulb (OB) neurons also evaluated. differentially compromises perception odors: it reduces Swiss Webster mice, while effect observed C57BL/6 J only for some odors. Additionally, reduced rate spontaneous spike firing periglomerular cells (PG-DA) OB. Because could reflect changes excitability and/or synaptic inputs, ability alter PG-DA activity tested together with cell membrane resistance, potential, rheobase chronaxie. Taken together, our data suggest affect perception.
Language: Английский
Citations
2
Current Neurovascular Research, Journal Year: 2024, Volume and Issue: 21(3), P. 229 - 233
Published: June 24, 2024
Language: Английский
Citations
1
Current Neurovascular Research, Journal Year: 2024, Volume and Issue: 21(2), P. 111 - 115
Published: Feb. 27, 2024
Language: Английский
Citations
0
Ain Shams Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 102981 - 102981
Published: Sept. 1, 2024
Language: Английский
Citations
0
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(12), P. 3537 - 3538
Published: Oct. 22, 2024
Language: Английский
Citations
0