Cited by Splenic γδ T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update DOI

Júlia Pauli De Cól,

Enzo Pereira de Lima,

Fernanda Moris Pompeu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3694 - 3694

Published: March 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Language: Английский

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An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus DOI

Jinni Hong, Tingting Fu, Weizhen Liu

et al.

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 1235 - 1248

Published: March 1, 2024

Abstract: Ruminococcus gnavus ( R. gnavus) is a gram-positive anaerobe commonly resides in the human gut microbiota. The advent of metagenomics has linked with various diseases, including inflammatory bowel disease (IBD), obesity, and diabetes mellitus (DM), which become growing area investigation. initial focus research primarily centered on assessing abundance its potential association presentation, taking into account variations sample size, sequencing analysis methods. However, recent investigations have shifted towards elucidating underlying mechanistic pathways through may contribute to manifestation. In this comprehensive review, we aim provide an updated synthesis current literature context IBD, DM. We critically analyze relevant studies summarize molecular mediators implicated between these diseases. Across numerous studies, molecules such as methylation-controlled J (MCJ), glucopolysaccharides, ursodeoxycholic acid (UDCA), interleukin(IL)-10, IL-17, capric been proposed contributors link IBD. Similarly, realm hydrogen peroxide, butyrate, UDCA suggested mediators, while glycine (GUDCA) connection Furthermore, it imperative emphasize necessity for additional evaluate efficacy targeting associated viable strategy managing These findings significantly expanded our understanding functional role This review aims offer insights mechanisms , well strategies treatment Keywords: disease,

Language: Английский

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Gut dysbiosis impacts the immune system and promotes prostate cancer DOI

Ritis Kumar Shyanti,

Jazmyn Greggs,

Shalie Malik

et al.

Immunology Letters, Journal Year: 2024, Volume and Issue: 268, P. 106883 - 106883

Published: June 12, 2024

Language: Английский

Citations

Mapping knowledge landscapes and research frontiers of gastrointestinal microbiota and bone metabolism: a text-mining study DOI

Haiyang Wu,

Zaijie Sun,

Qiang Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 10, 2024

Extensive research efforts have been dedicated to elucidating the intricate pathways by which gastrointestinal microbiota and their metabolites exert influence on processes of bone formation. Nonetheless, a notable gap exists in literature concerning bibliometric analysis trends at nexus metabolism.

Language: Английский

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Key actors in neuropathophysiology: The role of γδ T cells DOI

Deniz Bulgur,

Raquel Macedo Moura,

Julie C. Ribot

et al.

European Journal of Immunology, Journal Year: 2024, Volume and Issue: 54(12)

Published: Sept. 6, 2024

The neuroimmune axis has been the focus of many studies, with special emphasis on interactions between central nervous system and different immune cell subsets. T cells are namely recognized to play a critical role due their interaction nerves, by secreting cytokines neurotrophins, which regulate development, function, survival neurons. In this context, γδ particularly relevant, as they colonize specific tissues, meninges, have wide variety complex functions that balance physiological systems. Notably, not only key components for maintaining brain homeostasis but also responsible triggering or preventing inflammatory responses in various pathologies, including neurodegenerative diseases well neuropsychiatric developmental disorders. Here, we provide an overview current state art contribution neuropathophysiology delve into molecular mechanisms behind it. We aim shed light while highlighting upcoming challenges field providing new clues potential therapeutic strategies.

Language: Английский

Citations

Splenic γδ T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice DOI

Guilin Liu, Li Ma, Akemi Sakamoto

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 245, P. 173906 - 173906

Published: Nov. 15, 2024

Language: Английский

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