Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100

Published: Jan. 3, 2025

The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.

Language: Английский

Special Issue: “New Trends in Diabetes, Hypertension, and Cardiovascular Diseases—2nd Edition”

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 449 - 449

Published: Jan. 7, 2025

Cardiovascular diseases (CVDs) encompass a range of conditions affecting both the heart (e.g., coronary disease and failure [1]) blood vessels cerebrovascular [2] peripheral artery [3]) [...].

Language: Английский