Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 556 - 570
Published: Oct. 9, 2024
Language: Английский
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 22, 2025
Atherosclerosis is the primary cause of cardiovascular and cerebrovascular diseases. However, current anti-atherosclerosis drugs have shown conflicting therapeutic outcomes, thereby spurring search for novel effective treatments. Recent research indicates crucial involvement oral gastrointestinal microbiota in atherosclerosis. While gut metabolites, such as choline derivatives, been extensively studied reviewed, emerging evidence suggests that bacterial extracellular vesicles (BEVs), which are membrane-derived lipid bilayers secreted by bacteria, also play a significant role this process. BEVs host-microbiota interactions remains insufficiently explored. This review aims to elucidate complex communication mediated along gut-heart axis. In review, we summarize knowledge on BEVs, with specific focus how pathogen-derived contribute promotion atherosclerosis, well from symbionts probiotics may mitigate its progression. We explore potential challenges associated engineered prevention treatment Finally, discuss benefits using atherosclerosis diagnosis treatment, propose future directions address these issues.
Language: Английский
Citations
1
Microbiological Research, Journal Year: 2024, Volume and Issue: 285, P. 127788 - 127788
Published: June 1, 2024
Language: Английский
Citations
5
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(35), P. 19259 - 19273
Published: Aug. 23, 2024
Probiotics are known to modulate host immune responses in the course of many diseases. Recently, bacterial extracellular vesicles (EVs), which contain bioactive proteins, lipids, nucleic acids, and metabolites released by bacteria, have been identified as potentially important mediators bacteria-bacterium bacteria-host interactions. With deepening research, it has found that probiotic-derived EVs play a significant role regulating function and, thus, exerting health-promoting effects. Nevertheless, current research is its early stages, there remains long way go bridge gap between basic clinical practice. In this review, we describe fundamental aspects EVs, including their biogenesis, cargo sorting mechanism, transport capabilities. We further discussed potential mechanisms host's gut microbiota responses. Finally, speculate about new postbiotics for applications functional food, disease treatment substitutes, regulatory adjuvants.
Language: Английский
Citations
5
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Abstract Bacterial extracellular vesicles (EVs) are lipidic shuttles that play roles in virulence, inter-species competition, and the induction of host immune response. While they have primarily been investigated animal-bacteria interactions, knowledge regarding phytobacterial EVs remains limited. Recent findings revealed various biotic factors like hydroxycinnamic acids can regulate production. Hydroxycinnamic acids, such as ferulic acid, lignin components abundantly released plant environment, where impact ecology numerous phytobacteria. Azospirillum sp. B510, a phytobeneficial bacterium, induces accumulation acid derivatives metabolize them carbon sources. We hypothesized presence environment B510 would influence its production terms size, quantity, cargo. Conversely, we also proposed from this phytobacterium metabolites defense gene expression. Our results show both (mimicking environment) influences content by bacterial physiology at systemic level according to their cargoes. This research provides first evidence global effect on highlights dynamics plant-bacteria interactions mediated EVs.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3630 - 3630
Published: April 11, 2025
Increased abundance of Segatella copri (S. copri) within the gut microbiota is associated with systemic inflammatory diseases, including rheumatoid arthritis. Although outer-membrane vesicles (OMVs) Gram-negative bacteria are important players in microbiota–host communication, effect S. copri-derived OMVs on immune cells unknown. Macrophages engulf and eliminate foreign material conditioned by environmental signals to promote either homeostasis or inflammation. Thus, we aimed explore impact copri-OMVs human macrophages vitro, employing THP-1 monocyte-derived macrophage models. The uptake DiO-labeled into was monitored confocal microscopy flow cytometry. Furthermore, phenotype cytokine secretion naïve (M0), pro-inflammatory (M1), anti-inflammatory (M2) analyzed cytometry ELISA, respectively. We show that enter through macropinocytosis clathrin-dependent mechanisms. copri-OMVs, but not parental bacterium, induced a dose-dependent increase expression M1-related surface markers M0 M2 activated large amounts cytokines M1 macrophages. These results highlight an role promoting responses, which might contribute diseases.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 15, 2025
Outer membrane vesicles (OMVs) released by Helicobacter pylori (H.pylori) can enter the blood circulation of host and cause extra-gastric lesions such as atherosclerosis hyperemesis gravidarum. This study aimed to investigate effect OMVs H.pylori on development thymic T cells in offspring mice its underlying mechanisms. Through experimental observations, we found that were able cross placental barrier, leading a decrease number CD3+ CD4+ peripheral response stimulation. After stimulation with cell positive selection experiments, expression levels CHMP5, IKK-β, NF-κB are up-regulated, release cytokines IL-7, IL-2, IL-4, IFN-γ is simultaneously increased, whereas negative JNK CHMP5 Bcl-2 down-regulated E15-16 fetal thymus organ culture. These results indicate transmission H from mother fetus might be related central tolerance cells. The mechanism may involve an interaction between OMVs-stimulated pathway TCR pathway, although further research needed confirm this hypothesis. highlights importance preventing infection during pregnancy suggests centrally tolerated antigens needs considered vaccine design maximize prevention.
Language: Английский
Citations
0
Microbiological Research, Journal Year: 2025, Volume and Issue: 294, P. 128101 - 128101
Published: Feb. 14, 2025
Language: Английский
Citations
0
Journal of Extracellular Vesicles, Journal Year: 2024, Volume and Issue: 13(10)
Published: Oct. 1, 2024
Bacterial extracellular vesicles (BEVs) have emerged as pivotal mediators between bacteria and host. In addition to being crucial players in host homeostasis, they recently been implicated disease pathologies such cancer. Hence, the study of BEVs represents an intriguing rapidly evolving field with substantial translational potential. this review, we briefly introduce fundamentals BEV characteristics, cargo biogenesis. We emphatically summarize current relationship across various cancer types, illustrating their role tumorigenesis, treatment responses patient survival. further discuss inherent advantages BEVs, stability, abundance specific profiles, that make them attractive candidates for non-invasive diagnostic prognostic approaches. The review also explores potential a strategy therapy, considering ability deliver therapeutic agents, modulate tumour microenvironment (TME) elicit immunomodulatory responses. Understanding clinical significance may lead development better-targeted personalized strategies. This comprehensive evaluates progress surrounding poses questions encourage research emerging harness benefits full applications against
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8722 - 8722
Published: Aug. 9, 2024
The human microbiota is an intricate micro-ecosystem comprising a diverse range of dynamic microbial populations mainly consisting bacteria, whose interactions with hosts strongly affect several physiological and pathological processes. gut being increasingly recognized as critical player in maintaining homeostasis, contributing to the main functions intestine distal organs such brain. However, dysbiosis, characterized by composition function alterations intestinal barrier dysfunction has been linked development progression pathologies, including inflammatory diseases, systemic autoimmune rheumatic arthritis, neurodegenerative Alzheimer’s disease. Moreover, oral research gained significant interest recent years due its potential impact on overall health. Emerging evidence role microbiota–host health disease triggered marked functional bacterial extracellular vesicles (BEVs) mediators inter-kingdom communication. Accumulating reveals that BEVs mediate host transporting delivering into cells effector molecules modulate signaling pathways cell processes, influencing This review discusses from gut, lung, skin cavity epithelium, immune system, CNS interactions.
Language: Английский
Citations
1
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 556 - 570
Published: Oct. 9, 2024
Language: Английский
Citations
1