Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007–2016

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 9, 2024

To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.

Language: Английский

---

Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3990 - 3990

Published: April 23, 2025

Cellular senescence is a hallmark of aging and contributes to age-related diseases, including diabetic nephropathy (DN). Additionally, macrophage-mediated inflammation has been linked with DKD. Therefore, we investigated the effect macrophage depletion on kidney cell in DN, focusing relationship between GDF-15 Klotho signaling pathways. Wistar albino rats (n = 24) were divided into four groups: healthy control, liposomal clodronate (LC)-treated healthy, diabetic, LC-treated groups. Rats groups intravenously administered LC once week for 4 weeks. Rat models type 2 diabetes successfully established via administration streptozotocin high-fat diet, as evidenced by increased blood glucose levels, weight body (KW/BW) ratio, serum albumin, creatinine, urea damage, oxidative stress. However, LC-mediated reduced KW/BW improved parameters, decreased inflammatory markers (IL-6 TNF-α), ameliorated treatment promoted polarization towards anti-inflammatory phenotype, downregulated expression, upregulated damage. In conclusion, combats modulating GDF-15, indicating their potential novel targets DN treatment.

Language: Английский

---

Gender differences in the relationship between the triglyceride-glucose index and serum Klotho concentrations among the middle-aged and elderly: a cross-sectional analysis

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 10, 2024

Language: Английский

---

Lessons from Klotho mouse models to understand mineral homeostasis

Acta Physiologica, Journal Year: 2024, Volume and Issue: 240(10)

Published: Aug. 23, 2024

Abstract Aim Klotho, a key component of the endocrine fibroblast growth factor receptor—fibroblast axis, is multi‐functional protein that impacts renal electrolyte handling. The physiological significance Klotho will be highlighted in regulation calcium, phosphate, and potassium metabolism. Methods In this review, we compare several murine models with different targeted deletions insights into molecular function these offer. Results vivo, deficiency associated severely impaired mineral metabolism, consequences on growth, longevity disease development. Additionally, explore perspectives pathology vascular events, as well potential treatment options. Conclusion This comprehensive review emphasizes use to shed light deciphering vivo mechanisms handling, novel therapeutic interventions.

Language: Английский

---

Determination of the reference interval for urinary klotho to creatinine ratio of healthy dogs

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: July 23, 2024

For several years, alpha klotho has been considered as a candidate biomarker in chronic kidney disease (CKD), progression of CKD and mineral bone disorders (CKD-MBD). The evidence on the relationship between function is controversial some areas. aim study was to identify influence age, sex breed urinary klotho, values early stages within studied population determine reference interval group healthy dogs. Significantly higher were measured older dogs over 6 years old (

Language: Английский

---

Association of serum klotho level with albuminuria in middle‑aged and elderly participants without diabetes mellitus: a cross‑sectional study

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 18, 2024

Language: Английский

---