Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches DOI Creative Commons

Yang-Jin Shen,

Yin-Cheng Huang,

Yi‐Chuan Cheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 17 - 17

Published: Dec. 26, 2024

Spinal cord injury (SCI) initiates a cascade of secondary damage driven by oxidative stress, characterized the excessive production reactive oxygen species and other molecules, which exacerbate cellular tissue through activation deleterious signaling pathways. This review provides comprehensive critical evaluation recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, biomaterial applications. It emphasizes limitations single-regimen approaches, particularly their limited efficacy suboptimal delivery to injured spinal tissue, while highlighting synergistic potential combination therapies that integrate multiple modalities address multifaceted pathophysiology SCI. By analyzing emerging trends current limitations, this identifies key challenges proposes future directions, refinement antioxidant systems, development multi-targeted overcome structural complexities cord. work underscores pressing need innovative integrative approaches advance clinical translation interventions improve outcomes SCI patients.

Language: Английский

Ferulic Acid—A Brief Review of Its Extraction, Bioavailability and Biological Activity DOI Creative Commons
Krystyna Pyrzyńska

Separations, Journal Year: 2024, Volume and Issue: 11(7), P. 204 - 204

Published: July 1, 2024

Ferulic acid is a widespread phenolic compound that occurs in seeds and leaves, both its free form conjugated to polysaccharides, carbohydrates, glycoproteins lignins the plant cell walls. It exhibits various biological activities, like antioxidant, anticarcinogenic, anti-inflammatory, hepatoprotective, antimicrobial, antiviral activity, it modulates enzyme activity. Given these wide potential health benefits, ferulic has attracted considerable research interest may be considered biomolecule with strong prospects as functional food ingredient. Great attempts have been made enhance extraction process recovery from natural matrices agro-industrial wastes for applications relating human nutrition. This review presents recently available information on methods quantifying different samples, along bioavailability stability processing foods activities.

Language: Английский

Citations

18
Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach DOI Open Access

Polina Dobroslavska,

Maria Leonor Silva, Filipa Vicente

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1725 - 1725

Published: May 31, 2024

The global population is on a trajectory of continuous growth, with estimates projecting an increase from 7.7 billion in 2019 to approximately 9.7 by 2050. Longevity also expected rise rapidly, advancements healthcare contributing increased life expectancies and the maximum lifespan. aging process accompanied different changes, often leading decline daily activities susceptibility disease. Age-related changes can cause cellular damage subsequent death. Oxidative stress inflammation play significant roles this molecular mitochondrial dysfunction. Active has been associated improved quality reduced risk morbidity premature mortality. In context, Mediterranean diet emerged as promising approach promoting healthy sustainability. phytochemical compounds within have linked lower developing cardiovascular disease, type 2 diabetes, obesity, cancer neurodegenerative diseases. findings peer-reviewed articles regarding use sustainable dietary pattern written Portuguese, Spanish or English were included narrative literature review. This pattern’s emphasis consumption fresh local food aligns both health environmental sustainability goals. work provides comprehensive review benefits its components highlights importance approach.

Language: Английский

Citations

12
In Vitro Antiviral Activity of Eugenol on Singapore Grouper Iridovirus DOI

Yewen Wang,

Yunxiang Jiang,

Jiatao Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 151, P. 109748 - 109748

Published: July 2, 2024

Language: Английский

Citations

2
Inorganic pyrophosphatase 1: a key player in immune and metabolic reprogramming in ankylosing spondylitis DOI
Tianyou Chen, Chengqian Huang, Jiarui Chen

et al.

Genes and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

Citations

0
Differential Biological Effects of Trifolium pratense Extracts—In Vitro Studies on Breast Cancer Models DOI Creative Commons
Lucian Albulescu,

Alexandru Suciu,

Mihaela Neagu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1435 - 1435

Published: Nov. 22, 2024

The increasing popularity of herbal supplements emphasizes the need scientific data regarding their health benefits and possible toxicological concerns. complexity botanical extracts, which include thousands distinct compounds, contributes to challenging nature this endeavor. In study, we explored hormetic effects two Trifolium pratense extracts on breast cell lines. Using a wide range concentrations (0.1 3.33 mg/mL), analyzed how modulate cellular processes such as viability, proliferation, oxidative stress adenocarcinoma highly invasive estrogen receptor negative (ER-) noninvasive ER+ cells, well non-tumorigenic ER- normal cells. cytotoxicity real-time analysis (RTCA) assays showed that both exercised biphasic dose effect proliferation stress. We report monotonic dose-dependent cells; induced apoptosis was based pro-oxidant activity extracts. reactive oxygen species (ROS) generation by high-dose ethanolic extract observed in all followed mitochondria dysfunction. Oxidative parameters, malondialdehyde (MDA) reduced glutathione (GSH) levels, superoxide dismutase (SOD) were affected. Our study demonstrates T. have chemoprevention potential tumorigenic cells modulating

Language: Английский

Citations

0
Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches DOI Creative Commons

Yang-Jin Shen,

Yin-Cheng Huang,

Yi‐Chuan Cheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 17 - 17

Published: Dec. 26, 2024

Spinal cord injury (SCI) initiates a cascade of secondary damage driven by oxidative stress, characterized the excessive production reactive oxygen species and other molecules, which exacerbate cellular tissue through activation deleterious signaling pathways. This review provides comprehensive critical evaluation recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, biomaterial applications. It emphasizes limitations single-regimen approaches, particularly their limited efficacy suboptimal delivery to injured spinal tissue, while highlighting synergistic potential combination therapies that integrate multiple modalities address multifaceted pathophysiology SCI. By analyzing emerging trends current limitations, this identifies key challenges proposes future directions, refinement antioxidant systems, development multi-targeted overcome structural complexities cord. work underscores pressing need innovative integrative approaches advance clinical translation interventions improve outcomes SCI patients.

Language: Английский

Citations

0