Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

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Molecular Docking Analysis and In Vivo Assessment of Zinc Oxide Nanoparticle Toxicity in Zebrafish Larvae

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 276, P. 107112 - 107112

Published: Oct. 2, 2024

Language: Английский

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Molecular characterizations of nanodiamond and related carbon-based nanomaterials in the human cell line and zebrafish models

Diamond and Related Materials, Journal Year: 2025, Volume and Issue: 152, P. 111946 - 111946

Published: Jan. 5, 2025

Language: Английский

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Synergistic stress of zinc oxide nanoparticles and pH triggers gill damage and mortality in zebrafish

Nanotechnology for Environmental Engineering, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 28, 2025

Language: Английский

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Augmentation of betacyanin and quercetin in hybrid callus: Comprehensive assessment of biosynthesized silver nanoparticles for their potent biological activities, advanced in silico interactions, and rigorous toxicological evaluation

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 227, P. 120824 - 120824

Published: March 14, 2025

Language: Английский

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Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Language: Английский

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Folic acid functionalization of rGO/Co3O4/Chitosan based biocompatible nanocomposite enhances targeted delivery and cytotoxicity of Doxorubicin

Composites Communications, Journal Year: 2025, Volume and Issue: unknown, P. 102362 - 102362

Published: March 1, 2025

Language: Английский

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Antibacterial Mechanisms of Negatively and Positively Charged Ligands on Gold Nanoclusters

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Alleviation of mycobacterial infection by impairing motility and biofilm formation via natural and synthetic molecules

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(4)

Published: March 28, 2025

Language: Английский

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Exploring Oxidative Stress Mechanisms of Nanoparticles Using Zebrafish (Danio rerio): Toxicological and Pharmaceutical Insights

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 489 - 489

Published: April 18, 2025

Nanoparticles (NPs) have revolutionized biomedical and pharmaceutical applications due to their unique physicochemical properties. However, widespread use has raised concerns regarding potential toxicity, particularly mediated by oxidative stress mechanisms. This redox imbalance, primarily driven the overproduction of reactive oxygen species (ROS), plays a central role in NP-induced leading cellular dysfunction, inflammation, apoptosis, genotoxicity. Zebrafish (Danio rerio) emerged as powerful vivo model for nanotoxicology, offering advantages such genetic similarity humans, rapid development, optical transparency, allowing real-time monitoring damage. review synthesizes current findings on zebrafish, highlighting key toxicity mechanisms case studies involving metallic (gold, silver, copper), metal oxide (zinc oxide, titanium dioxide, iron oxide), polymeric, lipid-based NPs. The influence NP properties, size, surface charge, functionalization, responses is explored. Additionally, experimental approaches used assess ROS generation, antioxidant enzyme activity, damage biomarkers zebrafish models are examined. In addition concerns, antioxidant-modified NPs evaluated, drug delivery, neuroprotection, disease therapeutics. Notably, show that curcumin- quercetin-loaded nanoparticles enhance defense reduce neurotoxicity models, demonstrating promise neuroprotective therapies. Furthermore, cerium nanoparticles, which mimic catalase SOD enzymatic shown significant efficacy reducing protecting against Challenges zebrafish-based need standardized methodologies, future directions optimizing design minimize stress-related risks also discussed. By integrating insights from mechanisms, studies, strategies, this supports development safer more effective nanoparticle-based therapies while addressing challenges toxicity.

Language: Английский

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