Unlocking the Mechanisms of Hidradenitis Suppurativa: Inflammation and miRNA Insights DOI Creative Commons

Emily Ames,

Maggie Sanders,

M.‐C. Jacobs

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2829 - 2846

Published: Dec. 1, 2024

Abstract: Inflammatory skin diseases impose a significant burden on patients and healthcare systems worldwide. Among these, hidradenitis suppurativa (HS) is particularly notable for its chronic recurrent nature. Recurrent nodules, abscesses, scarring in apocrine gland-rich areas characterize the disease, including groin, axillae, perianal regions. Despite considerable physical psychological impact, precise mechanisms driving HS remain elusive. Recent advancements understanding inflammatory processes involved have highlighted TNF-alpha, IL-1β, IL-17/IL-23 pathways, which play crucial roles initiating perpetuating disease. Moreover, specific microRNAs (miRNAs), such as miR-24-1-5p, miR146a-5p, mirR-26a-5p, miR-206, miR-338-3p, miR-338-5p, are these processes. Dysregulation of miRNAs contributes to aberrant cytokine expression persistent inflammation, foreseeably exacerbating disease progression. This narrative review hypothesizes that miRNA dysregulation triggers contributing HS's clinical manifestations We explore implicated miRNAs' potential biomarkers earlier detection novel therapeutic targets. Identifying offers new opportunities more accurate diagnosis, potentially allowing clinicians intervene before severe occur. Furthermore, strategies modulate could target pathways HS, leading personalized effective treatments. also discusses future research directions enhance management HS. A better involvement avenues management, ultimately improving patient outcomes quality life. Keywords: sebaceous glands, immunosuppressant drugs,

Language: Английский

Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure DOI Open Access
Jenny Valentina Garmendia, Claudia Valentina De Sanctis, Marián Hajdúch

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1295 - 1295

Published: Feb. 3, 2025

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive losses before 24 weeks gestation. It affects 3-5% women who are attempting to conceive. RPL can stem from a variety causes and frequently associated with psychological distress diminished quality life. By contrast, recurrent implantation failure (RIF) refers inability achieve successful after three high-quality embryo transfers at least instances egg donation. RIF shares several causative factors RPL. The immunological underpinnings these conditions involve alterations in uterine NK cells, reductions M2 macrophages myeloid-derived suppressor an increased Th1/Th2 ratio, decreased Treg/Th17 presence shared ≥3 HLA alleles between partners, autoimmune disorders. Various therapeutic approaches have been employed address concerns, achieving varying degrees success, although some therapies remain contentious within medical community. This review intends explore implicated analyze treatments for conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, lymphocyte immunotherapy.

Language: Английский

Citations

2
Epigenetics in autoimmune diseases: Unraveling the hidden regulators of immune dysregulation DOI Creative Commons
Giacomo Bagni, Edoardo Biancalana,

Emanuele Chiara

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(6), P. 103784 - 103784

Published: March 3, 2025

Autoimmune diseases result from complex interactions between genetic and environmental factors. Recent advances in epigenetic research shed light on the intricate regulatory mechanisms that contribute to development progression of such conditions. The present review aims explore role modifications, including DNA methylation, histone non-coding RNAs, context autoimmune diseases. We discuss current understanding alterations associated with various disorders, their impact immune cell function, potential as innovative therapeutic targets. Additionally, we highlight main future directions field epigenetics autoimmunity.

Language: Английский

Citations

2
Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation DOI Creative Commons
Daniela Pinto,

Giammaria Giuliani,

Giorgia Mondadori

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 16 - 16

Published: Jan. 22, 2025

Exosomes, a subtype of extracellular vehicles (EVs), play pivotal role in cellular communication and have gained considerable attention dermatological research. Formed through the inward budding endosomal membrane, exosomes facilitate transfer proteins, lipids, nucleic acids, including microRNAs (miRNAs), thereby influencing behavior function recipient cells. These vesicles are secreted by various cell types, keratinocytes, crucial for maintaining skin homeostasis, regulating immune responses, promoting wound healing. Exosomes demonstrated therapeutic potential addressing conditions such as hair disorders, cancers photoaging enhanced regeneration reduced oxidative stress. However, they also implicated disease progression, with pathogens utilizing exosome release to evade host responses. Recent studies highlight diverse origins functions exosomes, suggesting their promise innovative agents dermatology. As research continues elucidate multifaceted roles, represent frontier understanding intercellular developing novel treatments skin-related diseases, underscoring impact on both health clinical applications. This review synthesizes existing literature biology isolation focus implications contexts.

Language: Английский

Citations

1
Methods for Extracellular Vesicle Isolation: Relevance for Encapsulated miRNAs in Disease Diagnosis and Treatment DOI Open Access
María Ljungström, Elisa Oltra

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 330 - 330

Published: March 12, 2025

Extracellular vesicles (EVs) are nanovesicles that facilitate intercellular communication by carrying essential biomolecules under physiological and pathological conditions including microRNAs (miRNAs). They found in various body fluids, such as blood, urine, saliva, their levels fluctuate with disease progression, making them valuable diagnostic tools. However, isolating EVs is challenging due to small size biological complexity. Here, we summarize the principles behind most common EV isolation methods ultracentrifugation, precipitation, immunoaffinity, sorting, ultrafiltration, exclusion chromatography, microfluidics while highlighting protocol strengths weaknesses. We also review main strategies identify quantify circulating miRNAs a particular focus on EV-encapsulated miRNAs. Since these hold special clinical interest derived from superior stability therapeutic potential, information provided here should provide guidance for future research initiatives promising field of treatment based

Language: Английский

Citations

1
MicroRNA regulation of enteric nervous system development and disease DOI
Amy Marie Holland, Reindert Jehoul,

Jorunn Vranken

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Towards personalized management of myasthenia gravis phenotypes: From the role of multi-omics to the emerging biomarkers and therapeutic targets DOI
Carmela Rita Balistreri, Claudia Vinciguerra, Daniele Magro

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(12), P. 103669 - 103669

Published: Oct. 18, 2024

Language: Английский

Citations

4
The Gut Microbiome Advances Precision Medicine and Diagnostics for Inflammatory Bowel Diseases DOI Open Access
Walaa K. Mousa,

A. Ali

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11259 - 11259

Published: Oct. 19, 2024

The gut microbiome emerges as an integral component of precision medicine because its signature variability among individuals and plasticity, which enables personalized therapeutic interventions, especially when integrated with other multiomics data. This promise is further fueled by advances in next-generation sequencing metabolomics, allow in-depth high-precision profiling communities, their genetic contents, secreted chemistry. knowledge has advanced our understanding microbial partners, interaction cellular targets, implication human conditions such inflammatory bowel disease (IBD). explosion data inspired the development therapeutics for treating IBD that depend on manipulating diet modulation or using live products therapeutics. current landscape artificial not limited to probiotics fecal transplants but expanded include community consortia, engineered probiotics, defined metabolites, bypassing several limitations hindered rapid progress this field safety regulatory issues. More research will reveal new targets enzymes receptors mediating interactions between microbiota-secreted molecules drive modulate diseases. With shift toward enhanced integration host genetics polymorphism treatment regimes, following key questions emerge: How can we effectively implement microbiomics personalize diseases like IBD, leveraging proven validated links? Can manage altering immune response? In review, discuss recent mechanism underpinning role microbes driving preventing IBD. We highlight developed targeted approaches reverse dysbiosis through editing microbiome. analyze opportunities while defining specific clinical niche innovative modality treatment, prevention, diagnosis potential medicine.

Language: Английский

Citations

4
Assessment of miR-19b-3p, miR-182-5p, and miR-155-5p expression and its relation DOI

Ahmed Ibrahim AbdElneam,

Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 22, 2025

Language: Английский

Citations

0
The power of microRNA regulation—insights into immunity and metabolism DOI Creative Commons
Stefania Oliveto, Nicola Manfrini, Stefano Biffo

et al.

FEBS Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

MicroRNAs (miRNAs) are a prominent class of small non‐coding RNAs that control gene expression. This comprehensive review explores the intricate roles miRNAs in metabolism and immunity, as well emerging field immunometabolism. The core this work delves into functional regulatory capabilities miRNAs, examining their complex influence on glucose lipid metabolism, pivotal shaping T‐cell development function. Specifically, addresses how orchestrate interaction between cellular metabolic processes immune responses, underscoring essential nature these molecules maintaining homeostasis. Finally, we examine role Artificial Intelligence (AI) miRNA research, focusing machine learning techniques revolutionizing identification validation potential biomarkers. By integrating diverse aspects, underscores multifaceted biological significant advancing biomedical research clinical applications.

Language: Английский

Citations

0
Differential expression levels of miR-125a, miR-125b, and miR-let-7f in sputum and plasma as biomarkers for tuberculosis DOI

Ali Nour Nematollahi,

Aria S. Kazemi,

Samira Tarashi

et al.

Human Gene, Journal Year: 2025, Volume and Issue: unknown, P. 201406 - 201406

Published: April 1, 2025

Language: Английский

Citations

0