Spotlight on the Mechanism of Action of Semaglutide DOI Creative Commons
Ilias Papakonstantinou, Konstantinos Tsioufis, Vasiliki Katsi

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 14514 - 14541

Published: Dec. 23, 2024

Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide or without diabetes presents significant therapeutic efficacy ameliorating cardiometabolic risk factors and physical functioning, independent of body reduction. Semaglutide may modulate adipose tissue browning, which enhances human metabolism exhibits possible benefits skeletal muscle degeneration, accelerated obesity ageing. This be attributed anti-inflammatory, mitochondrial biogenesis, antioxidant autophagy-regulating effects. However, most supporting evidence on mechanistic actions is preclinical, demonstrated rodents not actually confirmed humans, therefore warranting caution interpretation. article aims explore potential innovative molecular mechanisms action restoring balance several interlinking aspects metabolism, pointing distinct functions inflammation oxidative stress insulin-sensitive musculoskeletal tissues. Moreover, applications protection from infections anti-aging properties are discussed. enhancement core involved progress although mostly provide framework for future research diseases overall.

Language: Английский

Angiogenesis within Atherosclerotic Plaques: Mechanical Regulation, Molecular Mechanism and Clinical Diagnosis DOI Creative Commons
Hanxiao Chen,

Chih-Yu Peng,

Fei Fang

et al.

Mechanobiology in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100114 - 100114

Published: Feb. 1, 2025

Language: Английский

Citations

1
Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA DOI Creative Commons
Jumi Kim,

Jiseon Ha,

Chanho Song

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 9, 2025

Chronic hepatitis B virus (HBV) infection continues to be a global health concern because current treatments such as interferon-α and nucleos(t)ide analogs cannot fully eliminate the due persistence of covalently closed circular DNA (cccDNA) integrated HBV DNA. Earlier research suggests that AGK2, selective SIRT2 inhibitor, suppresses replication by modifying key signaling pathways. This study aimed further explore anti-HBV effects AKG2, particularly its on epigenetic landscape cccDNA. HBV-transfected -infected cells were used assess impact AGK2 viral replication. Changes in expression α-tubulin acetylation (SDS-PAGE-immunoblotting), core particle formation (native agarose gel electrophoresis immunoblotting), RNA (northern blotting) (Southern synthesis, cccDNA levels measured. Chromatin immunoprecipitation assays performed examine deposition transcriptionally repressive markers reduced SIRT2, increased acetylated levels, synthesis Importantly, also histone H4K20me1, H3K27me3, H3K9me3 cccDNA, mediated lysine methyltransferases PR-Set7, EZH2, SETDB1, SUV39H1. Additionally, there was reduction recruitment polymerase II H3 indicating enhances transcriptional repression. through direct antiviral actions, modulation using target associated regulators shows promise functional cure for chronic B.

Language: Английский

Citations

0
Spotlight on the Mechanism of Action of Semaglutide DOI Creative Commons
Ilias Papakonstantinou, Konstantinos Tsioufis, Vasiliki Katsi

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 14514 - 14541

Published: Dec. 23, 2024

Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide or without diabetes presents significant therapeutic efficacy ameliorating cardiometabolic risk factors and physical functioning, independent of body reduction. Semaglutide may modulate adipose tissue browning, which enhances human metabolism exhibits possible benefits skeletal muscle degeneration, accelerated obesity ageing. This be attributed anti-inflammatory, mitochondrial biogenesis, antioxidant autophagy-regulating effects. However, most supporting evidence on mechanistic actions is preclinical, demonstrated rodents not actually confirmed humans, therefore warranting caution interpretation. article aims explore potential innovative molecular mechanisms action restoring balance several interlinking aspects metabolism, pointing distinct functions inflammation oxidative stress insulin-sensitive musculoskeletal tissues. Moreover, applications protection from infections anti-aging properties are discussed. enhancement core involved progress although mostly provide framework for future research diseases overall.

Language: Английский

Citations

1