Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C–C and C–N Bond Formation in Biosynthetic Pathways DOI Creative Commons
Yaoyao Shen, Aimin Sun, Yisong Guo

et al.

ACS Bio & Med Chem Au, Journal Year: 2025, Volume and Issue: 5(2), P. 238 - 261

Published: March 10, 2025

Iron and 2-oxoglutarate dependent (Fe/2OG) enzymes utilize an FeIV═O species to catalyze the functionalization of otherwise chemically inert C–H bonds. In addition more familiar canonical reactions hydroxylation chlorination, they also several other types that contribute diversity complexity natural products. past decade, new Fe/2OG C–C C–N bond formation have been reported in biosynthesis structurally complex Compared with catalytic cycles these involve distinct mechanistic features enable noncanonical reaction outcomes. This Review summarizes recent discoveries involved a focus on mechanisms their roles product biosynthesis.

Language: Английский

Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C–C and C–N Bond Formation in Biosynthetic Pathways DOI Creative Commons
Yaoyao Shen, Aimin Sun, Yisong Guo

et al.

ACS Bio & Med Chem Au, Journal Year: 2025, Volume and Issue: 5(2), P. 238 - 261

Published: March 10, 2025

Iron and 2-oxoglutarate dependent (Fe/2OG) enzymes utilize an FeIV═O species to catalyze the functionalization of otherwise chemically inert C–H bonds. In addition more familiar canonical reactions hydroxylation chlorination, they also several other types that contribute diversity complexity natural products. past decade, new Fe/2OG C–C C–N bond formation have been reported in biosynthesis structurally complex Compared with catalytic cycles these involve distinct mechanistic features enable noncanonical reaction outcomes. This Review summarizes recent discoveries involved a focus on mechanisms their roles product biosynthesis.

Language: Английский

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