International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12495 - 12495

Published: Nov. 21, 2024

An abdominal aortic aneurysm (AAA) is described as a gradual and localized permanent expansion of the aorta resulting from weakening vascular wall. The key aspects AAA's progression are high proteolysis structural elements wall, depletion smooth muscle cells (VSMCs), chronic immunoinflammatory response. pathological mechanisms underpinning development an AAA complex still unknown. At present, there no successful drug treatments available that can slow or prevent rupture aneurysmal Recently, it has been suggested endothelial cellular senescence may be involved in aging diseases, but clear correlation between AAAs. Therefore, aim this study was to identify presence senescent on wall aneurysmatic aortas correlate their distribution with morphological markers Pathological healthy segments were collected during repair surgery immediately processed for histological immunohistochemical analyses. Hematoxylin/eosin, Verhoeff-van Gieson, Goldner's Masson trichrome staining procedures carried out investigate features related pathology. Immunohistochemical investigations p21

Language: Английский