STUDY OF COPPER COMPLEXES [Cu(LCF3)2] AND [Cu(Lcur)2]H2O AS RADIOPROTECTIVE COMPOUNDS DOI Creative Commons
Anahit Karapetyan, Carlo Santini, Maura Pellei

et al.

Archiv Euromedica, Journal Year: 2024, Volume and Issue: 14(4)

Published: Sept. 3, 2024

One of the first and direct signs impact ionizing radiation (IR) on a cell is destabilization chromosomes. Radiation-induced damage to karyotype an important indicator both for biological indication severity injuries predicting development long-term adverse effects IR. The search new, effective radioprotective compounds priority task modern radiobiology. In this area, metal-based with high antioxidant activity are particular interest. purpose work determine possible properties Cu(II) complexes, [Сu(LCF3)2] [Cu(Lcur)2]H2O, supported by anions β-diketone ligands 1,1,1,5,5,5-hexafluoro-2,4-pentanedione (HLCF3) 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione or curcumin (HLcur). research we determined survival, life expectancy cytogenetic parameters: mitotic index, chromosome aberrations % polyploid cells in bone marrow femur (count 1000 each preparation). Group I included intact animals; II consisted animals exposed radioisotope technetium; III that were intraperitoneally injected copper complex [Cu(LCF3)2] at dose 50 mg/kg volume 2 mL one hour before administration Tc isotope (“irradiation + compound [Cu(LCF3)2]); IV received [Cu(Lcur)2]H2O irradiation. groups injection had highest survival. terms chromosomal number cells, as indicators, significant difference was found those irradiated compared “irradiation [Cu(LCF3)2]” group (both after 15 30 days), which indicates property compound. tendency towards normalization noted days between Groups 3 end study (after also proves beneficial effect Analysis survival changes parameters multiregression analysis using complexes confirms greatest efficiency respect because when comparing it “pure irradiation” only toward observed. Multiregression confirmed comparison [Cu(Lcur)2]H2O. results indicate need continue direction searching agents have therapeutic injuries.

Language: Английский

Bridging the gap between theory and treatment: Transition metal complexes as successful candidates in medicine DOI

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216477 - 216477

Published: Feb. 8, 2025

Language: Английский

Citations

1
STUDY OF COPPER COMPLEXES [Cu(LCF3)2] AND [Cu(Lcur)2]H2O AS RADIOPROTECTIVE COMPOUNDS DOI Creative Commons
Anahit Karapetyan, Carlo Santini, Maura Pellei

et al.

Archiv Euromedica, Journal Year: 2024, Volume and Issue: 14(4)

Published: Sept. 3, 2024

One of the first and direct signs impact ionizing radiation (IR) on a cell is destabilization chromosomes. Radiation-induced damage to karyotype an important indicator both for biological indication severity injuries predicting development long-term adverse effects IR. The search new, effective radioprotective compounds priority task modern radiobiology. In this area, metal-based with high antioxidant activity are particular interest. purpose work determine possible properties Cu(II) complexes, [Сu(LCF3)2] [Cu(Lcur)2]H2O, supported by anions β-diketone ligands 1,1,1,5,5,5-hexafluoro-2,4-pentanedione (HLCF3) 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione or curcumin (HLcur). research we determined survival, life expectancy cytogenetic parameters: mitotic index, chromosome aberrations % polyploid cells in bone marrow femur (count 1000 each preparation). Group I included intact animals; II consisted animals exposed radioisotope technetium; III that were intraperitoneally injected copper complex [Cu(LCF3)2] at dose 50 mg/kg volume 2 mL one hour before administration Tc isotope (“irradiation + compound [Cu(LCF3)2]); IV received [Cu(Lcur)2]H2O irradiation. groups injection had highest survival. terms chromosomal number cells, as indicators, significant difference was found those irradiated compared “irradiation [Cu(LCF3)2]” group (both after 15 30 days), which indicates property compound. tendency towards normalization noted days between Groups 3 end study (after also proves beneficial effect Analysis survival changes parameters multiregression analysis using complexes confirms greatest efficiency respect because when comparing it “pure irradiation” only toward observed. Multiregression confirmed comparison [Cu(Lcur)2]H2O. results indicate need continue direction searching agents have therapeutic injuries.

Language: Английский

Citations

0