Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 167623 - 167623
Published: Dec. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 14, 2025
Glioblastoma(GBM) is a highly malignant primary central nervous system tumor that poses significant threat to patient survival due its treatment resistance and rapid recurrence.Current options, including maximal safe surgical resection, radiotherapy, temozolomide (TMZ) chemotherapy, have limited efficacy.In recent years, the role of glycolytic metabolic reprogramming in GBM has garnered increasing attention. This review delves into pivotal GBM, with particular focus on multifaceted roles lactate, key product, within microenvironment (TME). Lactate been implicated promoting cell proliferation, invasion, immune evasion. Additionally, this systematically analyzes potential therapeutic strategies targeting molecules pathway, such as Glucose Transporters (GLUTs), Monocarboxylate Transporters(MCTs), Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), Pyruvate Kinase Isozyme Type M2 (PKM2), Dehydrogenase A (LDHA). These studies provide novel perspective for treatment. Despite progress made existing research, challenges remain, drug penetration across blood-brain barrier, side effects, resistance. Future research will aim address these by improving delivery, minimizing exploring combination therapies immunotherapy develop more precise effective personalized GBM.
Language: Английский
Citations
2
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 29, 2024
Abstract Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study tumor has gradually become an emerging field treatment. Recent studies have shown that epigenetic regulation is closely linked to metabolism, influencing metabolic remodeling biological traits cells. This review focuses on primary pathways explores therapeutic strategies target these pathways. It covers key areas such as glycolysis, Warburg effect, mitochondrial function, oxidative phosphorylation, adaptability Additionally, this article examines regulator SWI/SNF complex specifically its interactions with glucose, lipids, amino acids. Summarizing aimed at pathways, including inhibitors mitochondrial-targeted drugs, exploitation vulnerabilities, recent developments related complexes potential targets. clinical significance, challenges, future directions research are discussed, overcome resistance, combination therapy, application new technologies.
Language: Английский
Citations
8
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 9, 2025
Osteosarcoma (OS), a prevalent metastatic cancer among young individuals, is associated with grim prognosis. Long non-coding RNAs (lncRNAs), including C1QTNF1-AS1, are pivotal regulators of cell proliferation and motility. As an oncogene, C1QTNF1-AS1 implicated in various tumor types, such as colorectal, pancreatic, hepatocellular carcinomas, OS. The aim this study was to investigate the functions underlying mechanisms progression osteosarcoma. This investigation focused on elucidating functional roles OS cells. Bioinformatics tools were utilized identify interaction between microRNA miR-34a-5p well targeting LDHA PDK3 by miR-34a-5p. Dual-luciferase reporter assays RNA immunoprecipitation employed validate these interactions. Expression profiles miR-34a-5p, LDHA, osteosarcoma cells analyzed using RT-PCR western blot analyses, revealing their intricate relationships. impact molecules proliferation, invasion, migration assessed through CCK-8, Transwell, Cell scratch assay. Moreover, effects aerobic glycolysis examined quantifying ATP levels, lactate production, glucose uptake capacity, extracellular acidification rate. findings indicated significant decrease expression levels compared normal osteoblasts. A parallel downregulation trend also observed Silencing led marked upregulation cells, which partially attenuated mimics. Functional evaluations demonstrated that suppression accelerated growth, motility, invasiveness, Warburg effect. Conversely, overexpression mitigated stimulatory effects, suggesting regulatory role modulating progression. Our research emphasizes critical pathogenesis (OS). We discovered indirectly upregulates suppressing regulator cascade events promotes enhancing glycolytic metabolism supplying energy for migration, invasion. These suggest potential therapeutic target highlight importance understanding network involving lncRNAs
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 13, 2025
Glioblastoma (GBM) ranks among the most lethal primary tumors of central nervous system. This is partly due to its complex intracellular metabolism and interactions with surrounding tumor microenvironment (TME). Compelling evidence represents that altered amino acids (AAs) plays a crucial role in both areas. The AAs their metabolites glioma biology an emerging topic. Therefore, this review was conducted summarize current knowledge about molecular mechanisms by which participate GBM pathogenesis. can directly influence progression affecting cell or indirectly releasing bioactive agents through particular metabolic pathways. begins examining pathways essential AAs, such as tryptophan, tyrosine, phenylalanine, contribute synthesizing critical neurotransmitters shape signatures. We explore how these impact growth immune modulation, focusing on promote malignant properties cells. also play pivotal reprogramming TME, contributing evasion resistance therapy. further discusses signatures, influenced AA metabolism, enhance immunosuppressive microenvironment, providing new avenues for targeted immunotherapies. Finally, we outline potential therapeutic strategies modulate emphasize opportunities future research improve management.
Language: Английский
Citations
0
Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101450 - 101450
Published: April 3, 2025
Language: Английский
Citations
0
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(5)
Published: May 28, 2024
Abstract Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) pathogenesis GBM. Analysis public datasets revealed ARNT upregulated GBM tissues compared lower grade gliomas or normal tissues. Higher expression correlated with mesenchymal subtype poorer survival patients. Silencing using lentiviral shRNAs attenuated proliferative, invasive, stem-like capabilities cell lines, while overexpression enhanced these malignant phenotypes. Single-cell RNA sequencing uncovered that highly expressed a subpopulation involved regulating glycolysis, hypoxia response, stress pathways. Mechanistic studies found activates p38 mitogen-activated protein kinase (MAPK) signaling promote chemoresistance cells. Disrupting ARNT/p38α interaction via PAS-A domain restored temozolomide sensitivity. Overall, this demonstrates functions as an oncogenic driver represents promising therapeutic target.
Language: Английский
Citations
2
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 167623 - 167623
Published: Dec. 1, 2024
Language: Английский
Citations
0