Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(12), P. 666 - 666
Published: Dec. 19, 2024
The only cells in an organism that could do any other sort of cell until 2006 (except sperm or egg) were known as embryonic stem cells, ESC [...]
Language: Английский
ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5148 - 5171
Published: Feb. 3, 2025
Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative affecting mostly the elderly population. The main pathological features of AD are extracellular Aβ plaques generated by APP cleavage through amyloidogenic pathway, intracellular neurofibrillary tangles (NFT) resulting from hyperphosphorylated tau proteins, and cholinergic neurodegeneration. However, actual causes unknown, but several studies suggest hereditary mutations in PSEN1 -2, APOE4, APP, TAU genes major perpetrators. In order to understand etiology pathogenesis AD, various hypotheses proposed. These include following hypotheses: amyloid accumulation, tauopathy, inflammation, oxidative stress, mitochondrial dysfunction, glutamate/excitotoxicity, deficiency, gut dysbiosis. Currently approved therapeutic interventions donepezil, galantamine, rivastigmine, which cholinesterase inhibitors (ChEIs), memantine, N-methyl-d-aspartate (NMDA) antagonist. treatment strategies focus on only symptomatic management attenuating symptoms not regeneration neurons or clearance Tau. This review focuses pathophysiology, novel targets, disease-altering treatments such as α-secretase modulators, active immunotherapy, passive natural antioxidant products, nanomaterials, antiamyloid therapy, aggregation inhibitors, transplantation fecal microbiota stem cells, microtubule stabilizers that clinical trials still under investigation.
Language: Английский
Citations
1
Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: March 19, 2025
Alzheimer's disease (AD), the leading cause of dementia, remains without adequate treatment. Current models do not fully replicate human physiology and pathology. The advent induced pluripotent stem cell (hiPSC) technology offers a novel approach to studying AD. Our study conducted bibliometric analysis assess application development hiPSC in AD research. We retrieved 531 articles on from Web Science Core Collection, published between January 2010 June 2024. CiteSpace VOSviewer were used analyze authorship, geographic contributions, journal influence, citation patterns. findings reveal steady increase publications over 14 years, with United States followed by China. Li-Huei Tsai Massachusetts Institute Technology is prominent researcher. PLoS One emerges as most influential journal. Research trends have focused inflammation, astrocytes, microglia, apolipoprotein E (ApoE), tau. Bibliometric crucial identifying research gaps guiding future studies address unmet needs understanding modeling Leveraging investigate molecular mechanisms familial sporadic expected provide foundation for developing treatment strategies. In summary, this comprehensive overview current landscape It also highlights emerging gaps, efforts, particularly exploring therapeutic targets improving mechanisms.
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2203 - 2203
Published: March 24, 2025
Recovery from traumatic spinal cord injury (tSCI) is challenging due to the limited regenerative capacity of central nervous system restore cells, myelin, and neural connections. At clinical level, fundamental pillars treatment are reduction in secondary damage (neuroprotection) rehabilitation; these tools we have mitigate disability caused by (SCI). To date, treatments on which neuroprotection has been based prevention acute respiratory failure avoid hypoxia, early hemodynamic control, neuroprotective drugs surgical management. Optimizing control ensure adequate perfusion may be key management SCI. While agents like methylprednisolone fallen into disuse, several promising therapies currently being tested trials. In terms treatment, although their impact neurological recovery remains debated, appropriate bone decompression followed duroplasty selected cases increasingly recommended. Advances cell hold significant potential for enhancing both functional outcomes SCI patients. Moreover, emerging neuromodulation techniques, such as transcutaneous epidural stimulation, along with innovations rehabilitation technologies-such robotic systems exoskeletons-are becoming indispensable improving locomotion overall mobility individuals This article provides an update advances against tSCI, cellular therapies, new therapies.
Language: Английский
Citations
0
Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 249 - 319
Published: Jan. 1, 2024
Language: Английский
Citations
2
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10180 - 10199
Published: Sept. 14, 2024
Neuromodulatory subcortical systems (NSSs) are monoaminergic and cholinergic neuronal groups that markedly precociously involved in the pathogenesis of many neurodegenerative disorders (NDDs), including Parkinson’s Alzheimer’s diseases. In humans, although tools have been developed to infer information on these nuclei, encompassing neuroimaging neurophysiological methods, a detailed specific direct evaluation their cellular features vivo has difficult obtain until recent years. The development induced pluripotent stem cell (iPSC) models allowed research deeply delve into molecular biology NSS neurons. fact, iPSCs can be produced easily non-invasively from patients’ fibroblasts or circulating blood monocytes, by de-differentiating those cells using protocols, then re-differentiated towards neural phenotypes, which may reproduce correspondent brain neurons (including ones) same patient. this review, we summarized findings obtained field NDDs iPSCs, with aim understand how reliably might represent vitro NSS. We found most current literature NSSs focused midbrain dopaminergic disease, providing interesting results pathophysiology even leading first human autologous transplantation. Differentiation protocols for noradrenergic, cholinergic, serotoninergic also recently defined published. Thus, it expected near future, approach could extend other NDDs.
Language: Английский
Citations
1
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: July 11, 2024
Language: Английский
Citations
0
In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2024, Volume and Issue: 60(9), P. 1021 - 1033
Published: Aug. 12, 2024
Language: Английский
Citations
0
Precision and Future Medicine, Journal Year: 2024, Volume and Issue: 8(3), P. 65 - 73
Published: Sept. 6, 2024
Understanding the genetic basis and pathomechanisms underlying dementia arising from single-gene mutations is crucial to expand our knowledge in field of research. In this review, we comprehensively summarize results existing research using induced pluripotent stem cells (iPSCs) investigate familial Alzheimer’s disease caused by presenilin-1 (PSEN1), presenilin-2 (PSEN2), or amyloid precursor protein (APP) genes. We further review iPSC studies leukodystrophies, including Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts Leukoencephalopathy (CADASIL), notch receptor 3 (NOTCH3) gene; adult-onset leukoencephalopathy axonal spheroids pigmented glia (ALSP), colony-stimulating factor 1 (CSF1R) gene. systematically advantages necessity iPSCs elucidate pathogenesis neurodegenerative diseases, particularly facilitate modeling. Furthermore, introduce applied based on technology. Through aimed help mechanisms which causative genes induce symptoms would contribute development effective treatment strategies.
Language: Английский
Citations
0
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 87(1), P. 250 - 264
Published: Dec. 11, 2024
Induced pluripotent stem cells (iPSCs) provide a novel approach to studying the pathophysiology of brain tumors and assessing various therapeutic techniques with greater precision. This study aims systematically review existing literature critically analyze synthesize current research findings. The objective is evaluate role iPSCs in understanding development innovative treatment strategies. We reviewed articles that utilized iPSC technology assess either or techniques, following standards Preferred Reporting Items for Systematic Meta-Analysis guidelines. Key terms were comprehensively searched electronic databases, including PubMed, EMBASE, Scopus. Articles screened based on specific inclusion exclusion criteria. Ultimately, 22 relevant chosen, their data extracted. summary findings each selected article was organized into two general categories: "Methods Generating iPSCs" "Applications iPSCs." methods generation, transfection transduction, as well types viral non-viral vectors used, extracted reported study. Additionally, main studies, whether modeling approaches, gathered results section. vehicle brings new solutions overcome difficulties tumor studies. In vivo vitro models generated from suitable platforms investigate more precisely. Also, have been studies examine how different antitumor agents may affect target cells.
Language: Английский
Citations
0
Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(12), P. 666 - 666
Published: Dec. 19, 2024
The only cells in an organism that could do any other sort of cell until 2006 (except sperm or egg) were known as embryonic stem cells, ESC [...]
Language: Английский
Citations
0