Changes in the Microbiome During Chronic Rhinosinusitis DOI Creative Commons
Mateusz de Mezer,

Nina Chalama,

Cheyanna Bratt

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 14(1), P. 14 - 14

Published: Dec. 30, 2024

Chronic rhinosinusitis (CRS) is a common inflammatory disease of the paranasal sinuses with yet unknown etiology. As studies continue to elucidate disease's heterogeneity profile and presentation, there growing interest in influence nasal microbiome on pathogenesis chronicity. The sinus microbiota appear dominated by Staphylococcus Corynebacterium genera; known upper airway pathogens, such as Haemophilus influenza, are present airways healthy individuals, though at relatively lower abundances than CRS patients. Viral culprits may induce an unhindered local immune response that contributes recurrence chronicity inverted papillomas-benign mucosal lesions propensity for destruction malignant transformation can be found patients history infection. persistence papillomas warrants investigation into their how they contribute landscape promoting CRS. Further needed uncover interplay between resident viral, fungal, immunological influence. Discerning 'healthy' 'diseased' sinonasal microbiomes 'keystone' species could shed light etiology provide opportunity treatment tailored individual's microbiome. This review aims explore interrelation microbial residents diseased environment.

Language: Английский

Changes in the Microbiome During Chronic Rhinosinusitis DOI Creative Commons
Mateusz de Mezer,

Nina Chalama,

Cheyanna Bratt

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 14(1), P. 14 - 14

Published: Dec. 30, 2024

Chronic rhinosinusitis (CRS) is a common inflammatory disease of the paranasal sinuses with yet unknown etiology. As studies continue to elucidate disease's heterogeneity profile and presentation, there growing interest in influence nasal microbiome on pathogenesis chronicity. The sinus microbiota appear dominated by Staphylococcus Corynebacterium genera; known upper airway pathogens, such as Haemophilus influenza, are present airways healthy individuals, though at relatively lower abundances than CRS patients. Viral culprits may induce an unhindered local immune response that contributes recurrence chronicity inverted papillomas-benign mucosal lesions propensity for destruction malignant transformation can be found patients history infection. persistence papillomas warrants investigation into their how they contribute landscape promoting CRS. Further needed uncover interplay between resident viral, fungal, immunological influence. Discerning 'healthy' 'diseased' sinonasal microbiomes 'keystone' species could shed light etiology provide opportunity treatment tailored individual's microbiome. This review aims explore interrelation microbial residents diseased environment.

Language: Английский

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