Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review DOI
Abeer Kazmi, Tahira Sultana

Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016

Published: March 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Language: Английский

Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword DOI Creative Commons

Sina Kamrani,

Reza Naseramini,

Pouria Khani

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Language: Английский

Citations

1
MMP14 from BM-MSCs facilitates progression and Ara-C resistance in acute myeloid leukemia via the JAK/STAT pathway DOI Creative Commons

Jinxian Wu,

Xinqi Li, Ying Liu

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 22, 2025

Abstract Growing evidence underscores the pivotal impact of crosstalk between leukemic stem cells (LSCs) and mesenchymal stromal (MSCs) within their niche on leukemia initiation, progression, therapy response. Although MMP14 plays an important role in inflammation cancer, regulation MSC-derived acute myeloid (AML) are largely unknown. Here, we found that AML patient-derived MSCs (AML-MSCs) were more supportive cell growth compared to healthy donor-derived (HD-MSCs). Moreover, AML-MSCs HD-MSCs showed significant differences gene expression protein profiles. Knockdown inhibited CFU-F ability MSC increased proportion G0 phase, thereby inhibiting proliferation. Co-culture with proliferation cycle progression cells, while increasing apoptosis rate, thus impairing leukemogenic potential both vitro vivo. Mechanistic studies revealed MMP14-mediated alterations microenvironment driven by PGE2 secretion activation JAK-STAT pathway, promoting progression. Notably, inhibition can attenuate chemotherapy resistance induced cytarabine (Ara-C). Together, our study, for first time, demonstrates critical chemoresistance. Targeting signaling pathways may offer novel therapeutic options AML.

Language: Английский

Citations

0
Exploring the bone marrow micro environment in thalassemia patients: potential therapeutic alternatives DOI Creative Commons
Zengzheng Li, Xiangmei Yao, Jie Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 5, 2024

Genetic mutations in the β-globin gene lead to a decrease or removal of chain, causing build-up unstable alpha-hemoglobin. This condition is referred as beta-thalassemia (BT). The present treatment strategies primarily target correction defective erythropoiesis, with particular emphasis on therapy and hematopoietic stem cell transplantation. However, presence inefficient erythropoiesis BT bone marrow (BM) likely disturb previously functioning BM microenvironment. includes accumulation various macromolecules, damage function, destruction production osteoblast(OBs), so on. In addition, changes microenvironment may have certain correlation occurrence hematological malignancies. Correction can be achieved through treatments such iron chelation, antioxidants, hypoglycemia, biologics. Hence, review describes some potential remedies.

Language: Английский

Citations

2
Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review DOI
Abeer Kazmi, Tahira Sultana

Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016

Published: March 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Language: Английский

Citations

0