Induced Pluripotent Stem Cells-Based Regenerative Therapies in Treating Human Aging-Related Functional Decline and Diseases

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 619 - 619

Published: April 21, 2025

A significant increase in life expectancy worldwide has resulted a growing aging population, accompanied by rise aging-related diseases that pose substantial societal, economic, and medical challenges. This trend prompted extensive efforts within many scientific communities to develop enhance therapies aimed at delaying processes, mitigating functional decline, addressing aging-associated extend health span. Research biology focused on unraveling various biochemical genetic pathways contributing changes, including genomic instability, telomere shortening, cellular senescence. The advent of induced pluripotent stem cells (iPSCs), derived through reprogramming human somatic cells, revolutionized disease modeling understanding humans the limitations conventional animal models primary cells. iPSCs offer advantages over other such as embryonic they can be obtained without need for embryo destruction are not restricted availability healthy donors or patients. These attributes position iPSC technology promising avenue deciphering mechanisms underlie associated diseases, well studying drug effects. Moreover, exhibit remarkable versatility differentiating into diverse cell types, making them tool personalized regenerative replacing aged damaged with healthy, equivalents. review explores breadth research iPSC-based their potential applications spectrum conditions.

Language: Английский

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Modern cell culture technologies: Revolutionizing neuroregeneration in neuropsychiatry

Archives of Biological Psychiatry, Journal Year: 2024, Volume and Issue: 2, P. 14 - 24

Published: July 6, 2024

This review highlights the latest developments in current cell culture methods, including three-dimensional culture, organoids, coculture systems, microfluidics, and nanofiber scaffolds to support neuroregeneration major neuropsychiatric illnesses. Due enhanced vitro modeling of human brain structure function, these state-of-the-art methods allow for investigations disease processes drug screening, pathophysiological research on has increased. We examine recent relationship between technologies conditions such as stroke, Alzheimer’s, traumatic injury, spinal cord injury. The advancements present encouraging prospects augmenting could facilitate stem cell-based therapies ailments that were previously untreatable.

Language: Английский

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Advances in Mesenchymal Stem Cell Therapy and Natural Antioxidants for Hepatic Fibrosis: A Comprehensive Review

Deleted Journal, Journal Year: 2024, Volume and Issue: 2, P. 100016 - 100016

Published: March 1, 2024

Liver damage resulting from the administration of various allopathic drugs and their associated toxicity has become a major health problem, leading to hepatic fibrosis, cirrhosis, metabolic disorders. This epidemic condition liver disease represents global cause death morbidity. Although orthotopic transplantation remains vital treatment option for fibrotic conditions, its efficacy is limited by organ scarcity risk immunological rejection. Consequently, alternative therapeutic approaches are urgently needed. Cell-based therapy utilizing mesenchymal stem cells (MSCs) garnered considerable interest as promising modality. MSCs exhibit immunomodulatory properties can differentiate into hepatocytes, thus facilitating regeneration damaged hepatocytes increasing residual hepatocyte proliferation while inhibiting activation or apoptosis stellate cells. However, despite potential benefits, transplanted often low survival rates due inadequate oxidative inflammatory stress resistance. Plants harbor diverse array bioactive compounds known possess hepatoprotective antioxidant properties. Nanomaterials play crucial role in regenerative medicine providing targeted delivery agents scaffolds tissue engineering. In treating liver, nanomaterials help mitigate fibrosis progression promote through controlled release anti-fibrotic growth factors. review highlights synergistic cell-based therapy, natural antioxidants, differentiation factors, nanotechnology combating advancing medicine. These combined offer avenues effectively conditions promoting regeneration.

Language: Английский

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Progress of induced pluripotent stem cell (iPSC)-derived renal organoids in clinical application

Kidney Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 11, 2024

Background: Kidney disease has become a growing public health problem worldwide, and there is an urgent need to develop reliable models for investigating novel effective treatment strategies. In recent years, kidney organoids, as different from traditional two-dimensional cells model animals, have attracted more attention. Current advances allowed the generation of organoids directed differentiation induced pluripotent stem (iPSCs), which possess similar characteristics embryonic cells, but bypass ethical constraints wide range sources. Summary: Herein, methods generating renal iPSCs, applications iPSC-derived in modeling, drug effectiveness detection, regenerative medicine well challenges were reviewed. Key Messages: can be used diseases are great studying injury toxicity. Many efforts needed finally apply into clinical application.

Language: Английский

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Liver organoids: From 3D printing to biomedical applications

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract The liver is an immune organ, especially tolerance organ. critical shortage of donor organs and disease models for the treatment end‐stage failure underscores urgent need generation organoids from human induced pluripotent stem cells (iPSCs). Notably, significant advancements have been made in study over past decade. construction has transitioned single cell type to multicellular models, two‐dimensional three‐dimensional cultures. Here we provide progress surrounding different culture techniques 3D printing organ‐on‐chip, as well focuses on present future applications organoids, then challenges perspectives ahead further advancement.

Language: Английский

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