The Role of Diet, Additives, and Antibiotics in Metabolic Endotoxemia and Chronic Diseases

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 704 - 704

Published: Dec. 13, 2024

Background/Objectives: Dietary patterns, including high-fat and high-carbohydrate diets (HFDs HCDs), as well non-dietary factors such food additives antibiotics, are strongly linked to metabolic endotoxemia, a critical driver of low-grade chronic inflammation. This review explores the mechanisms through which these impair intestinal permeability, disrupt gut microbial balance, facilitate lipopolysaccharide (LPS) translocation into bloodstream, contributing disorders obesity, type 2 diabetes mellitus, inflammatory bowel disease. Methods: The analysis integrates findings from recent studies on effects dietary components microbiota interactions barrier function systemic Focus is given experimental designs assessing permeability using biochemical histological methods, alongside profiling in both human animal models. Results: HFDs HCDs were shown increase LPS levels, inducing dysbiosis compromising integrity. resulting endotoxemia promoted state inflammation, disrupting regulation pathogenesis various diseases. Food antibiotics further exacerbated by altering composition increasing permeability. Conclusions: Diet-induced alterations dysfunction emerge key mediators related disorders. Addressing patterns their impact health crucial for developing targeted interventions. Further research warranted standardize methodologies elucidate translating clinical applications.

Language: Английский

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Association between lipid accumulation product and chronic obstructive pulmonary disease: a cross-sectional study based on U.S. adults

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Lipid Accumulation Product (LAP), which is derived from measurements of waist circumference and triglyceride (TG) levels, serves as a comprehensive indicator lipid accumulation. Emerging research indicates that accumulation dysfunction might significantly contribute to the pathogenesis Chronic Obstructive Pulmonary Disease (COPD). Nevertheless, investigation into association between LAP COPD risk still insufficient, particularly in population-based research. This intends examine possible correlation likelihood developing COPD. study, designed cross-sectional analysis, made use data gathered National Health Nutrition Examination Survey (NHANES) spanning years 2017 2020, encompassing total 7,113 eligible participants. LAP, exposure variable, was calculated using concentration. diagnosis determined participants' self-reported information. To explore COPD, multivariate logistic regression models were applied, smoothing curve fitting employed any potential nonlinear patterns. Further analysis included stratified subgroup evaluations assess how variables such sex, smoking habits, alcohol intake impact relationship The findings indicated significant increase with each one-unit rise ln evidenced by an Odds Ratio (OR) 1.16 [95% Confidence Interval (CI): 1.04-1.30, p < 0.01]. Furthermore, quartile-based revealed individuals highest category had considerably higher compared those lowest category, OR 1.35 (95% CI: 1.04-1.75, P for trend <0.01). identified positive suggesting steeper values rise. Subgroup suggested this remained fairly consistent across various demographic groups. study found link levels elevated displaying pattern. As marker abnormalities, may serve valuable tool assessing could inform strategies early identification targeted clinical management.

Language: Английский

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Intestinal Microbiota Dysbiosis Role and Bacterial Translocation as a Factor for Septic Risk

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2028 - 2028

Published: Feb. 26, 2025

The human immune system is closely linked to microbiota such as a complex symbiotic relationship during the coevolution of vertebrates and microorganisms. transfer microorganisms from mother's newborn begins before birth gestation considered initial phase intestinal (IM). gut an important site where can establish colonies. IM contains polymicrobial communities, which show interactions with diet host immunity. tendency towards dysbiosis influenced by local but also extra-intestinal factors inflammatory processes, infections, or septic state that aggravate it. Pathogens could trigger response, proinflammatory responses. In addition, changes in influence community structure additional translocation pathogenic non-pathogenic bacteria. Finally, inflammation has been found be factor growth microorganisms, particularly its role sepsis. aim this article able detect current knowledge mechanisms lead cause bacterial risk infection vice versa.

Language: Английский

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Beneficial Changes in Total Cholesterol, LDL-C, Biomarkers of Intestinal Inflammation, and Vitamin E status in Adults with Metabolic Syndrome Consuming Almonds as Snack Foods: A Randomized Controlled Clinical Trial

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4359 - 4359

Published: Dec. 18, 2024

Traumatic brain injury (TBI) represents a multifaceted pathological condition resulting from external forces that disrupt neuronal integrity and function. This narrative review explores the intricate relationship between dietary macronutrients, gut microbiota (GM), neuroinflammation in TBI. We delineate dual aspects of TBI: immediate mechanical damage (primary injury) subsequent biological processes (secondary exacerbate damage. Dysregulation gut–brain axis emerges as critical factor neuroinflammatory response, emphasizing role GM mediating immune responses. Recent evidence indicates specific including lipids, proteins, probiotics, can influence composition turn modulate neuroinflammation. Moreover, specialized interventions may promote resilience against secondary insults support neurological recovery post-TBI. aims to synthesize current preclinical clinical on potential strategies mitigating pathways, suggesting targeted nutrition health optimization could serve promising therapeutic modalities TBI management.

Language: Английский

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Endothelial Dysfunction and Liver Cirrhosis: Unraveling of a Complex Relationship

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12859 - 12859

Published: Nov. 29, 2024

Endothelial dysfunction (ED) is the in background of multiple metabolic diseases and a key process liver disease progression cirrhosis decompensation. ED affects sinusoidal endothelial cells (LSECs) response to different damaging agents, causing their progressive dedifferentiation, unavoidably associated with an increase intrahepatic resistance that leads portal hypertension hyperdynamic circulation increased cardiac output low peripheral artery resistance. These changes are driven by continuous interplay between hepatic cell types, invariably leading reactive oxygen species (ROS) formation, release pro-inflammatory cytokines chemokines, reduced nitric oxide (NO) bioavailability, subsequent loss proper vascular tone regulation fibrosis development. evaluation often accomplished serum markers flow-mediated dilation (FMD) measurement brachial assess its NO-dependent shear stress, which usually decreases ED. In context cirrhosis, assessment could help understand complex hemodynamic occurring early late stages disease. However, instauration state NO bioavailability systemic circulation—often defined as paradox—must be considered confounding factors during FMD analysis. The primary purpose this review describe main features highlight findings dynamic intriguing relationship We will also focus on significance setting, pointing out role therapeutic target never-ending battle against progression.

Language: Английский

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The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus

Life, Journal Year: 2024, Volume and Issue: 14(7), P. 784 - 784

Published: June 21, 2024

Type 2 diabetes mellitus (T2DM) is a burgeoning public health challenge worldwide. Individuals with T2DM are at increased risk for skeletal muscle atrophy, serious complication that significantly compromises quality of life and which effective prevention measures currently inadequate. Emerging evidence indicates systemic local inflammation stemming from the compromised intestinal barrier one crucial mechanisms contributing to atrophy in patients. Notably, natural plant polysaccharides were found be capable enhancing function mitigating secondary some diseases. Herein, we hypothesized

Language: Английский

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