The 10-year temporal evolution of respiratory support and associated outcomes in extremely premature infants: betting on a favourable forecast for the next decade

European Respiratory Journal, Journal Year: 2025, Volume and Issue: 65(1), P. 2402194 - 2402194

Published: Jan. 1, 2025

Language: Английский

---

Safety, Efficacy and Bio-Distribution Analysis of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells for Effective Treatment of Bronchopulmonary Dysplasia by Intranasal Administration in Mice Model

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2521 - 2553

Published: Feb. 1, 2025

Exosomes (Exos) derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) hold great potential for treating bronchopulmonary dysplasia (BPD); however, safety concerns and effects of intranasal administration remain unexplored. This study aimed to explore the hUC-MSCs Exos investigate efficacy bio-distribution repeated in neonatal BPD models. Characteristics were analyzed. A subcutaneous tumor formation assay using a single dose or was conducted Crl:NU-Foxn1nu mice. Vital signs, biochemical indices, pathological alterations, 18F-FDG microPET/CT analysis examined. Pulmonary pathology, three-dimensional reconstructions, ultrastructural structures, vivo ex imaging analyses, enzyme-linked immunoassay assays, reverse transcription-quantitative polymerase chain reaction analyses lung tissues all documented following administration. satisfied specifications. mice did not exhibit overt toxicity carcinogenicity after 60 days observation. Repeated effectively alleviated injuries, restored pulmonary ventilation reconstruction, recovered endothelial cell layer integrity analysis. steadily accumulated postnatal day 1 14. also interrupted epithelial-mesenchymal transition inflammation reactions As nanoscale, non-cellular therapy, an effective, noninvasive treatment BPD. approach free toxic, tumorigenic risks repaired alveolar damage while interrupting with

Language: Английский

---

Harnessing the therapeutic potential of mesenchymal stem cells in cancer treatment

Advanced Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 14(3), P. 574 - 590

Published: June 22, 2024

Cancer, as a complicated disease, is considered to be one of the major leading causes death globally. Although various cancer therapeutic strategies have been established, however, some issues confine efficacies treatments. In recent decades researchers for finding efficient solutions extensively focused on abilities stem cells in inhibition. Mesenchymal (MSCs) are multipotent stromal that can most widely extracted from sources such bone marrow (BM), placenta, umbilical cord (UC), menses blood, Wharton's jelly (WJ), adipose tissue and dental pulp (DP). These capable differentiating into osteoblasts, chondrocytes, adipocytes. Due unique characteristics MSCs paracrine effects, immunomodulation, tumor-tropism, migration, they promising candidates therapeutics. Currently, an excellent living carrier delivery genes chemical agents target tumor sites. Also, exosomes, important extracellular vesicle released MSCs, act strong cell-free tool prevent progression by inhibiting several signaling pathways, wnt/β-catenin PI3K/AKT/mTOR. However, there challenges associated with use their exosomes field therapy need considered. This review explores significance cell-based therapy, focusing homing properties immunomodulatory characteristics. It also examines potential using carriers anticancer role modulating signal transduction pathways cells.

Language: Английский

---

Promises and challenges of stem cell cargo therapy for bronchopulmonary dysplasia

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Language: Английский

---