Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 29, 2025

Adipose tissue plays a critical role in the development of metabolically unhealthy obesity (MUO), with distinct adipose depots demonstrating functional differences. This study aimed to investigate unique characteristics subcutaneous (SA) and visceral (VA) MUO. Paired omental VA abdominal SA samples were obtained from four male patients MUO subjected Four-Dimensional Data Independent Acquisition (4D-DIA) proteomic lysine acetylation (Kac) analyses. Differentially expressed proteins differentially modified Kac sites identified, quantified, integrated, Overlap analysis was performed between our datasets previously published populations. Additionally, on histones their related enzymes identified. A total 281 147 identified among 6,201 quantifiable 1,826 sites. Upregulated acetylated predominantly enriched extracellular matrix (ECM) remodeling pathways, while those energy metabolism disease-related pathways. Differential ECM adaptability primarily mediated by fibranexin integrin, COL6A1, COL6A3, ITGA5 as overlapping dataset previous studies. Potential inflammatory processes closely associated modifications. Specific histones, including H1.2K63, H1XK90, H3.7K80, showed increased VA, N-deacetylase/N-sulfotransferase 1 (NDST1) enzyme. provided comprehensive acetylomic profiles laying foundation for investigating pathogenesis potential therapeutic approaches characterized pronounced regulation, exhibited poorer more prominent metabolic changes. These differential influenced not only protein expression levels but, importantly, The regulation modifications white (WAT), particularly inflammation-related may serve an effective intervention strategy MUO, NDST1 emerging promising target. Not applicable since this did involve clinical intervention.

Language: Английский

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Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: July 24, 2024

Cardiovascular disease and cancer are the two leading causes of morbidity mortality in world. The emerging field cardio-oncology described several shared risk factors that predispose patients to both cardiovascular cancer. Post-acute COVID-19 syndrome is a chronic condition occurs many who have experienced SARS-CoV-2 infection, mainly based on fatigue, sedentary lifestyle, cramps, breathing difficulties, reduced lung performance. exposes increased visceral adiposity, insulin resistance, myosteatosis, white adipose tissue content (surrounded by M1 macrophages characterized Th1/Th17 phenotype), which increases recurrence. In this review, main metabolic affections post-acute at low high cardiomyopathies will be summarized. Furthermore, non-pharmacological strategies aimed reducing atherosclerotic cardiac provided, especially through anti-inflammatory nutrition with glycemic index, appropriate physical activity, immune-modulating bioactivities able reduce obesity improving insulin-related signaling myocardial metabolism.

Language: Английский

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SUBCUTANEOUS ADIPOSE TISSUE RADIODENSITY: AN EMERGING RISK FACTOR FOR SEVERE COVID-19

Nutrition, Journal Year: 2024, Volume and Issue: 128, P. 112561 - 112561

Published: Aug. 22, 2024

Language: Английский

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New Insights into Adipose Tissue Metabolic Function and Dysfunction, 2nd Edition

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9258 - 9258

Published: Aug. 27, 2024

The adipose organ is well recognized for its role in energy storage and mobilization, responding to nutrient availability, the body’s needs, thermogenesis, thereby regulating organism’s balance [...]

Language: Английский

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