Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(2)
Published: Dec. 5, 2024
Ferroptosis
is
a
form
of
programmed
cell
death
that
distinct
from
apoptosis.
The
mechanism
involves
redox‑active
metallic
iron
and
characterized
by
an
abnormal
increase
in
iron‑dependent
lipid
reactive
oxygen
species,
which
results
high
levels
membrane
peroxides.
relationship
between
ferroptosis
gynaecological
tumours
complex.
can
regulate
tumour
proliferation,
metastasis
chemotherapy
resistance,
targeting
promising
antitumour
approach.
interacts
with
mechanisms
related
to
tumorigenesis
development,
such
as
macrophage
polarization,
the
neutrophil
trap
network,
mitochondrial
autophagy
cuproptosis.
present
review
examines
recent
information
on
interaction
molecular
other
tumour‑related
mechanisms,
well
involvement
tumours,
identify
implications
for
cancer
therapy.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3689 - 3689
Published: Oct. 31, 2024
The
identification
of
reliable
prognostic
biomarkers
is
crucial
for
optimizing
cancer
treatment
strategies,
especially
in
the
era
personalized
medicine.
This
systematic
review
and
meta-analysis
evaluate
significance
neutrophil-to-eosinophil
ratio
(NER)
various
types,
with
a
focus
on
its
association
overall
survival
(OS)
progression-free
(PFS).
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 16, 2025
Neutrophils,
traditionally
considered
as
non-specific
components
of
the
innate
immune
system,
have
garnered
considerable
research
interest
due
to
their
dual
roles
in
both
promoting
and
inhibiting
tumor
progression.
This
paper
seeks
clarify
specific
mechanisms
by
which
neutrophils
play
a
bidirectional
role
immunity
factors
that
influence
these
roles.
By
conducting
comprehensive
analysis
synthesis
vast
array
relevant
literature,
it
has
become
evident
can
development
invasive
migration
through
various
mechanisms,
thereby
exerting
anti-tumor
effects.
Conversely,
they
also
facilitate
tumorigenesis
proliferation,
well
affect
normal
physiological
functions
other
cells,
thus
pro-tumor
Moreover,
are
influenced
cells
unique
microenvironment,
turn
affects
heterogeneity
plasticity.
Neutrophils
interact
with
regulate
aspects
life
activities
precisely.
identifies
unresolved
issues
concerning
development,
offering
new
opportunities
challenges
for
advancing
our
understanding.
This,
turn,
aid
proper
application
insights
clinical
treatment
strategies.
Cancer Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 15
Published: Sept. 19, 2024
Neutrophils,
which
originate
from
the
bone
marrow
and
are
characterized
by
a
segmented
nucleus
brief
lifespan,
have
crucial
role
in
body’s
defense
against
infections
acute
inflammation.
Recent
research
has
uncovered
complex
roles
of
neutrophils
as
regulators
tumorigenesis,
during
exhibit
dualistic
nature
that
promotes
or
inhibits
tumor
progression.
This
adaptability
is
pivotal
within
microenvironment
(TME).
In
this
review,
we
provide
comprehensive
characterization
neutrophil
plasticity
heterogeneity,
aiming
to
illuminate
current
findings
discuss
potential
therapeutic
avenues.
By
delineating
intricate
interplay
TME,
review
further
underscores
urgent
need
understand
dual
functions
with
particular
emphasis
on
anti-tumor
effects
facilitate
development
effective
strategies
cancer.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 817 - 817
Published: Feb. 26, 2025
Despite
multimodal
therapies,
the
treatment
of
glioblastoma
remains
challenging.
In
addition
to
very
complex
mechanisms
cancer
cells,
including
specialized
phenotypes
that
enable
them
proliferate,
invade
tissues,
and
evade
immunosurveillance,
they
exhibit
a
pronounced
resistance
chemo-
radiotherapy.
More
advanced
tumors
create
hypoxic
environment
supports
their
proliferation
survival,
while
robust
angiogenesis
ensures
constant
supply
nutrients.
GBM,
these
structures
are
contribute
creation
maintenance
highly
immunosuppressive
microenvironment
promotes
tumor
growth
immune
escape.
addition,
high
accumulation
tumor-infiltrating
leukocytes
other
expression
checkpoint
molecules,
low
mutational
burden,
i.e.,
number
neoantigens,
hallmarks
GBM
challenge
therapeutic
approaches.
Here,
we
review
exploits
support
potential
treatments.
These
include
new
chemotherapeutics,
treating
fields,
small
compounds
targeting
or
blockers
tyrosine
kinases
inhibit
cell
survival.
focus
on
immunotherapies
such
as
blockade
in
particular
vaccination
with
dendritic
cells
CAR-T
which
can
either
kill
directly
bypass
immunosuppression
by
modulating
boosting
patient's
own
response.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 302 - 302
Published: Feb. 28, 2025
Excessive
alcohol
consumption
significantly
impacts
human
health,
particularly
the
brain,
due
to
its
susceptibility
oxidative
stress,
which
contributes
neurodegenerative
conditions.
Alcohol
metabolism
in
brain
occurs
primarily
via
catalase,
followed
by
CYP2E1
pathways.
Excess
metabolized
generates
reactive
oxygen/nitrogen
species
(ROS/RNS),
leading
cell
injury
altering
many
different
Elevated
stress
impairs
autophagic
processes,
increasing
post-translational
modifications
and
further
exacerbating
mitochondrial
dysfunction
ER
death.
The
literature
highlights
that
alcohol-induced
disrupts
autophagy
mitophagy,
contributing
neuronal
damage.
Key
mechanisms
include
dysfunction,
epigenetics,
accumulation
of
oxidatively
modified
proteins,
lead
neuroinflammation
impaired
cellular
quality
control.
These
processes
are
exacerbated
chronic
exposure,
resulting
suppression
protective
pathways
like
NRF2-mediated
antioxidant
responses
increased
changes
brain.
Alcohol-mediated
neurotoxicity
involves
complex
interactions
between
metabolism,
regulation,
influenced
various
factors
such
as
drinking
patterns,
nutritional
status,
genetic/environmental
factors,
highlighting
need
for
molecular
studies
unravel
these
develop
targeted
interventions.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 14, 2025
The
objective
of
this
study
is
to
investigate
the
relationship
between
neutrophil-to-lymphocyte
ratio
(NLR)
and
all-cause
as
well
cause-specific
mortality
among
patients
with
kidney
stones,
evaluate
capability
NLR
a
predictor
mortality.
This
included
2,995
stones
from
NHANES
database
during
period
2007
2018,
subsequently
linked
data
National
Death
Index.
was
analyzed
using
Cox
proportional
hazards
model
Kaplan-Meier
survival
curves.
Additionally,
restricted
cubic
spline
(RCS)
curves
were
employed
explore
dose-response
mortality,
while
time-dependent
ROC
utilized
assess
predictive
for
Finally,
mediating
effect
estimated
glomerular
filtration
rate
(eGFR)
on
also
analyzed.
ultimately
median
follow-up
74
months.
A
total
395
deaths
recorded,
which
87
attributed
cardiovascular
diseases.
An
cut-off
3.62
identified
significantly
associated
outcomes
'maxstat'
package
principle
maximum
rank
statistics.
plot
indicates
non-linear
both
After
adjusting
relevant
covariates,
regression
analysis
demonstrated
that,
in
comparison
lower
group,
higher
group
exhibited
1.05-fold
(HR
2.05,
95%
CI
1.51-2.78,
P
<
0.001)
increased
risk
1.99-fold
2.99,
1.89-4.72,
Furthermore,
eGFR
significant
found
that
exhibiting
high
have
U.S.
population.
Therefore,
monitoring
may
be
important
prognosis
stones.
Cancer Medicine,
Journal Year:
2025,
Volume and Issue:
14(7)
Published: March 27, 2025
A
tumor
is
composed
of
more
than
tumoral
cells.
In
recent
years,
there
has
been
an
increase
in
interest
and
knowledge
the
microenvironment
(TME).
The
TME
integral
part
tumor,
several
cells:
immune,
stromal,
endothelial,
among
others,
thus
offering
a
wide
range
interactions
multiple
possibilities
for
targeted
therapies
environment
modulation.
While
pancreatic
ductal
adenocarcinoma
widely
studied,
it
not
very
true
neuroendocrine
neoplasms
(PNENs).
incidence
PNENs
increasing
and,
therefore,
important
to
comprehend
their
biology
evolution
efficient
since
many
develop
metastasis,
including
G1
PNENs.
This
paper
focuses
on
review
role
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(4), P. 853 - 853
Published: April 2, 2025
DLBCL
is
a
testament
to
the
complexity
of
nature.
It
characterized
by
remarkable
diversity
in
its
molecular
and
pathological
subtypes
clinical
manifestations.
Despite
strides
made
treatment
introduction
innovative
drugs,
around
one-third
patients
face
relapse
or
develop
refractory
disease.
Recent
findings
over
past
ten
years
have
highlighted
critical
interplay
between
evolution
various
epigenetic
mechanisms,
including
chromatin
remodeling,
DNA
methylation,
histone
modifications,
regulatory
roles
non-coding
RNAs.
These
alterations
are
integral
pathways
oncogenesis,
tumor
progression,
development
therapeutic
resistance.
In
decade,
identification
dysregulated
mechanisms
lymphomas
has
paved
way
for
an
exciting
field
therapies.
Crucially,
these
transformations
span
beyond
cells
include
sophisticated
network
within
microenvironment
(TME).
While
exploration
dysregulation
lymphoma
thriving,
affecting
functions
immune
TME
invite
further
investigation.
This
review
dedicated
weaving
together
narrative
impacting
both
with
focus
on
their
infiltrating
companions.
