Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(2)
Published: Dec. 5, 2024
Ferroptosis
is
a
form
of
programmed
cell
death
that
distinct
from
apoptosis.
The
mechanism
involves
redox‑active
metallic
iron
and
characterized
by
an
abnormal
increase
in
iron‑dependent
lipid
reactive
oxygen
species,
which
results
high
levels
membrane
peroxides.
relationship
between
ferroptosis
gynaecological
tumours
complex.
can
regulate
tumour
proliferation,
metastasis
chemotherapy
resistance,
targeting
promising
antitumour
approach.
interacts
with
mechanisms
related
to
tumorigenesis
development,
such
as
macrophage
polarization,
the
neutrophil
trap
network,
mitochondrial
autophagy
cuproptosis.
present
review
examines
recent
information
on
interaction
molecular
other
tumour‑related
mechanisms,
well
involvement
tumours,
identify
implications
for
cancer
therapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
26(1), P. 6 - 6
Published: Dec. 24, 2024
Colorectal
cancer
(CRC)
is
often
associated
with
metastasis
and
recurrence
the
leading
cause
of
cancer-related
mortality.
In
progression
CRC,
recent
studies
have
highlighted
critical
role
neutrophils,
particularly
tumor-associated
neutrophils
(TANs).
TANs
both
tumor-promoting
tumor-suppressing
activities,
contributing
to
metastasis,
immunosuppression,
angiogenesis,
epithelial-to-mesenchymal
transition.
Tumor-promoting
promote
tumor
growth
by
releasing
proteases,
reactive
oxygen
species,
cytokines,
whereas
enhance
immune
responses
activating
T
cells
natural
killer
cells.
Understanding
mechanisms
underlying
TAN
mobilization,
plasticity,
their
in
microenvironment
has
revealed
potential
therapeutic
targets.
This
review
provides
a
comprehensive
overview
biology
CRC
discusses
functions
neutrophils.
Novel
approaches
targeting
TANs,
such
as
chemokine
receptor
antagonists,
aim
modulate
neutrophil
reprogramming
offer
promising
avenues
for
improving
treatment
outcomes
CRC.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: May 23, 2024
Background
Tertiary
lymphoid
structures
(TLS)
is
a
particular
component
of
tumor
microenvironment
(TME).
However,
its
biological
mechanisms
in
colorectal
cancer
(CRC)
have
not
yet
been
understood.
We
desired
to
reveal
the
TLS
gene
signature
CRC
and
evaluate
role
prognosis
immunotherapy
response.
Methods
The
data
was
sourced
from
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO)
databases.
Based
on
TLS-related
genes
(TRGs),
related
subclusters
were
identified
through
unsupervised
clustering.
TME
between
evaluated
by
CIBERSORT
xCell.
Subsequently,
developing
risk
model
conducting
external
validation.
Integrating
score
clinical
characteristics
create
comprehensive
nomogram.
Further
analyses
conducted
screen
hub
explore
relationship
genes,
TME,
processes,
using
random
forest
analysis,
enrichment
variation
competing
endogenous
RNA
(ceRNA)
network
analysis.
Multiple
immunofluorescence
(mIF)
immunohistochemistry
(IHC)
employed
characterize
existence
expression
gene.
Results
Two
that
enriched
or
depleted
identified.
two
had
distinct
prognoses,
characteristics,
immune
infiltration.
established
prognostic
including
14
validated
predictive
power
datasets.
model’s
AUC
values
for
1-,
3-,
5-year
overall
survival
(OS)
0.704,
0.737,
0.746.
low-risk
group
superior
rate,
more
abundant
infiltration
cells,
lower
dysfunction
exclusion
(TIDE)
score,
exhibited
better
efficacy.
In
addition,
we
selected
top
important
features
within
model:
VSIG4
,
SELL
PRRX1
.
Enrichment
analysis
showed
significantly
affected
signaling
pathways
progression.
ceRNA
network:
-miRNA
(
hsa-miR-20a-5p
hsa-miR-485–5p
)
-lncRNA
has
discovered.
Finally,
IHC
mIF
results
confirmed
level
markedly
elevated
TLS-
group.
Conclusion
study
thoroughly
describe
CRC.
applicable
prediction
assessment
TLS-hub
which
potential
function
as
an
immunomodulatory
factor
TLS,
could
be
therapeutic
target
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 4, 2024
Background
Neutrophils
have
long
been
consistently
adjudged
to
hold
a
dominant
position
in
acute
inflammation,
which
once
led
people
undervalue
their
role
chronic
malignancy.
It
is
now
acknowledged
that
neutrophils
also
infiltrate
into
the
tumor
microenvironment
substantial
quantities
and
form
highly
abundant
immune
population
within
tumor,
known
as
tumor-associated
(TANs).
There
has
surge
of
interest
researching
eminent
heterogeneity
plasticity
TANs
recent
years,
scholars
increasingly
cotton
on
multifaceted
functions
so
strenuous
endeavors
devoted
enunciating
potential
therapeutic
targets.
Yet
it
remains
much
left
translate
TAN-targeted
immunotherapies
clinical
practice.
Therefore,
there
great
significance
comprehensively
appraise
research
status,
focal
point,
evolution
trend
TAN
by
using
bibliometric
analysis.
Methods
Publications
related
from
2000
2024
are
extracted
Web
Science
Core
Collection.
Bibliometric
analysis
visualization
were
performed
tools
encompassing
Microsoft
Excel,
VOSviewer,
CiteSpace,
R-bibliometrix,
on.
Results
The
included
total
788
publications
authored
5291
affiliated
with
1000
institutions
across
58
countries/regions,
relevant
articles
published
324
journals.
Despite
China’s
maximum
quantity
top
10
institutions,
United
States
leading
country
most
high-quality
global
cooperation
center.
FRONTIERS
IN
IMMUNOLOGY
papers,
whereas
CANCER
RESEARCH
highest
co-cited
journal.
Israeli
professor
Fridlender,
Zvi
G.
founder,
pioneer,
cultivator
citation
counts
H-index
area.
Our
prefigures
future
trajectories:
heterogeneity,
neutrophil
extracellular
trap,
crosstalk
between
immunocytes,
immunotherapy
will
likely
be
focus
research.
Conclusion
A
comprehensive
visual
first
map
current
landscape
intellectual
structure
TAN,
proffers
fresh
perspectives
for
further
accurate
identification
distinct
subpopulations
precise
targeting
key
pro-tumor/anti-tumor
immense
develop
immunotherapy.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 25, 2024
Osteosarcoma
is
a
cancerous
bone
tumor
that
develops
from
mesenchymal
cells
and
characterized
by
early
metastasis,
easy
drug
resistance,
high
disability,
mortality.
Immunological
characteristics
of
the
microenvironment
(TME)
have
attracted
attention
for
prognosis
treatment
osteosarcoma,
there
need
to
explore
signature
with
sensitivity
prognosis.
In
present
study,
total
84
samples
osteosarcoma
were
acquired
UCSC
Xena
database,
analyzed
immune
infiltration
classified
into
two
categories
depending
on
their
properties,
then
screened
DEGs
between
groups
enrichment,
majority
enriched
in
domain.
To
further
analyze
characteristics,
immune-related
genes
obtained
TIMER
database.
We
performed
an
intersection
analysis
identify
differentially
expressed
(IR-DEGs),
which
using
univariate
COX
regression,
LASSO
was
used
obtain
ideal
construct
risk
model,
uncover
prognostic
distinctions
high-risk
scoring
group
low-risk
group,
survival
conducted.
The
assessment
model
developed
this
study
revealed
notable
variation
outcomes
groups,
conclusions
reached
are
consistent
findings
previous
scholars.
They
also
yield
meaningful
results
when
analyzing
checkpoints.
precise
dependable
forecasting
osteosarcoma.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 9, 2024
Abstract
Osteosarcoma
is
a
cancerous
bone
tumor
that
develops
from
mesenchymal
cells
and
characterized
by
early
metastasis,
easy
drug
resistance,
high
disability,
mortality.
Immunological
characteristics
of
the
microenvironment
(TME)
has
attracted
attention
for
prognosis
treatment
osteosarcoma,
there
need
to
explore
signature
with
sensitivity
prognosis.
In
present
study,
total
84
samples
osteosarcoma
were
acquired
UCSC
Xena
database,
analyzed
immune
infiltration
classified
into
two
categories
depending
on
their
properties,
then
screened
DEGs
between
groups
enrichment,
majority
enriched
in
domain.
To
further
analyze
characteristics,the
related
genes
obtained
TIMER
we
performed
an
intersection
analysis
identify
immune-related
differentially
expressed
(IR-DEGs),
which
using
univariate
COX
regression
LASSO
was
used
obtain
ideal
constructing
risk
model,
uncover
prognostic
distinctions
high-risk
scoring
group
low-risk
group,
survival
conducted.
The
assessment
model
developed
this
study
revealed
notable
variation
outcomes
groups,
conclusions
reached
are
consistent
findings
previous
scholars
also
yield
meaningful
results
when
analyzing
checkpoints.
precise
dependable
forecasting
osteosarcoma.
Clinical and Experimental Obstetrics & Gynecology,
Journal Year:
2024,
Volume and Issue:
51(5)
Published: May 9, 2024
Background:
Infiltration
of
immune
cells
associated
with
tumor
clinical
results
affects
different
cancers.
However,
the
composition
and
significance
tumor-infiltrated
in
epithelial
ovarian
cancer
has
not
been
completely
investigated.
Methods:
The
metagene
deconvolution
algorithm
(Cell
type
Identification
by
Estimating
Relative
Subsets
known
RNA
Transcripts
(CIBERSORT))
was
used
to
analyze
gene
expression
profiles
public
databases
(GEO
TCGA)
infer
22
cell
subgroups
tumors.
proportions
obtained
this
study
were
investigate
association
between
each
outcomes
for
diagnosis
prognosis.
Quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
detecting
levels
related
genes.
Results:
infiltration
altered
malignant
neoplastic
tissue.
Ovarian
tissues
contained
higher
proportion
T
follicular
helper
(Tfh)
macrophages
(M0
M1)
rather
than
normal
Meanwhile,
lower
monocytes
neutrophils
also
observed
compared
tissues.
qRT-PCR
test
confirmed
conclusion
that
contents
CD80
(M1
cells)
CD4+
(Tfh
high
interstitium
tissue,
while
CD21
(B
CD66b
(neutrophil)
low.
Interestingly,
be
correlated
change
outcome.
activated
mast
subpopulation
poor
prognosis,
resting
dendritic
pathological
grade
cancer.
Conclusions:
Our
bioanalysis
revealed
tumor-infiltrating
closely
outcome
cancer,
which
validated
samples.
These
provide
a
new
strategic
basis
prognosis
treatment
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(2)
Published: Dec. 5, 2024
Ferroptosis
is
a
form
of
programmed
cell
death
that
distinct
from
apoptosis.
The
mechanism
involves
redox‑active
metallic
iron
and
characterized
by
an
abnormal
increase
in
iron‑dependent
lipid
reactive
oxygen
species,
which
results
high
levels
membrane
peroxides.
relationship
between
ferroptosis
gynaecological
tumours
complex.
can
regulate
tumour
proliferation,
metastasis
chemotherapy
resistance,
targeting
promising
antitumour
approach.
interacts
with
mechanisms
related
to
tumorigenesis
development,
such
as
macrophage
polarization,
the
neutrophil
trap
network,
mitochondrial
autophagy
cuproptosis.
present
review
examines
recent
information
on
interaction
molecular
other
tumour‑related
mechanisms,
well
involvement
tumours,
identify
implications
for
cancer
therapy.
