Current status of research on the role of natural products and their active ingredients in the treatment of cardiovascular aging: a narrative review

Aging advances., Journal Year: 2025, Volume and Issue: 2(2), P. 67 - 74

Published: April 8, 2025

Aging is a multifaceted physiological process marked by alterations in human appearance and the progressive decline organ function. With intensification of global population aging, health older individuals has emerged as critical concern, particularly given significant impact cardiovascular aging on overall outcomes. Although an inevitable natural process, strategies aimed at delaying its progression can enhance In recent years, products have garnered increasing attention for their potential disease intervention, attributed to high efficacy relatively low side-effect profiles. These demonstrated anti-aging effects several studies. This review provides comprehensive overview mechanisms underlying reviews biological activities various active constituents combating aging. It encompasses latest findings trends from both vitro vivo studies, thereby offering theoretical foundation development novel, side effect, rapidly acting drugs that target Natural exert anti-cardiovascular through multiple mechanisms, including antioxidant activity, apoptosis inhibition, anti-thrombosis, anti-fibrosis, anti-atherosclerosis, blood pressure regulation. For instance, water-soluble components Salvia miltiorrhiza , such tanshinone salvianolic acid B, improve function modulating oxidative stress inflammatory responses. Ligustrazine Rhizoma Chuanxiong reduces myocardial injury activating phosphatidylinositol 3-kinase-protein kinase B signaling pathway, whereas Ginkgo biloba leaf extract enhances vascular regulating inflammation. Additionally, animal-derived products, antler peptides royal jelly, cardioprotective effects. However, current studies possess limitations, with insufficient evidence supporting clinical application many products. Their long-term safety humans require further validation. Despite these challenges, hold improving among elderly. continued research into action advancement trials, they are expected become important tools enhancing quality life Future should explore develop safer more effective drugs, contributing positively societal health.

Language: Английский

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Comprehensive evaluation of non-coding RNA-mediated autophagy regulation in myocardial ischemia-reperfusion injury

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Ischemic heart disease remains a major global health challenge, with myocardial ischemia-reperfusion injury (MIRI) being one of its most common and severe pathophysiological complications. The pathogenesis MIRI is multifaceted, involving oxidative stress, inflammatory responses, apoptotic pathways, autophagic regulation. Notably, autophagy exerts dual regulatory effect, where maintaining optimal flux essential for cardiac homeostasis. Emerging evidence underscores the crucial role non-coding RNAs (ncRNAs) in modulating these pathological processes. In particular, long (lncRNAs), microRNAs (miRNAs), circular (circRNAs) have been identified as key regulators autophagy-mediated progression through complex molecular networks. This review provides systematic analysis pathways which ncRNAs influence pathogenesis, specific focus on their autophagy-regulatory mechanisms. These insights may enhance our understanding pathobiology facilitate development novel therapeutic strategies.

Language: Английский

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circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12351 - 12351

Published: Nov. 18, 2024

The Guangling Large-Tailed sheep is renowned for its unique tail fat deposition, with a significant proportion of total body being localized in the region. Fat deposition complex biological process regulated by various molecular mechanisms. Our previous studies have identified large number differentially expressed circular RNAs (circRNAs) adipose tissue sheep. These circRNAs may play pivotal role deposition. Given potential regulatory functions metabolism, investigating their roles scientific importance. In this study, we novel circARID1A. Using experimental methods, including lentivirus infection, RNase R treatment, actinomycin D assay, qPCR, western blotting, and dual-luciferase reporter assays, determined that circARID1A inhibits expression miR-493-3p through competitive binding, thereby regulating adipocyte differentiation. Further research revealed promotes differentiation targeting YTH domain family 2 (YTHDF2), effect also influenced conclusion, our findings suggest cell circARID1A/miR-493-3p/YTHDF2 axis, providing theoretical support improving meat quality

Language: Английский

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Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1417 - 1417

Published: Aug. 25, 2024

Breakthroughs in surgical and medical techniques have significantly improved outcomes for children with congenital heart disease (CHD), but research continues to address the ongoing challenge of organ dysfunction after surgery, particularly neonates infants. Our study explored circular RNAs (circRNAs) within plasma-derived extracellular vesicles (EVs) infants undergoing CHD surgery. Post-surgery EV circRNAs showed dramatic expression changes between (OD) control groups. Tissue injury-related pathways were consistent across pre- post-surgery OD. The top two significant predicted tissue sources these originated from respiratory system, aligning fact that all patients OD arm experienced dysfunction. Five circRNAs, namely circ-CELSR1, circ-PLXNA1, circ-OBSL1, circ-DAB2IP, circ-KANK1, correlated PELOD (Pediatric Logistic Organ Dysfunction) score demonstrated high performance (AUC = 0.95), supporting potential as prognostic markers. These findings pave way promising tools managing post-surgical potentially guiding therapeutic strategies CHD.

Language: Английский

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Circular RNAs in coronary heart disease: From molecular mechanism to promising clinical application (Review)

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(1)

Published: Oct. 31, 2024

Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide, posing substantial public health burden. Despite advancements in treatment, the complex etiology CHD necessitates ongoing exploration novel diagnostic markers therapeutic targets. Circular RNAs (circRNAs), distinct class non‑coding with covalently closed loop structure, have emerged as significant regulators various diseases, including CHD. Their high stability, tissue‑specific expression evolutionary conservation underscore their potential biomarkers agents This review discusses current knowledge on circRNAs context explores molecular mechanisms by which influence pathophysiology CHD, cardiomyocyte death, endothelial injury, vascular dysfunction inflammation. It also summarizes emerging evidence highlighting differential patients utilities non‑invasive prognostic targets for this disease.

Language: Английский

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