Journal of Applied Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Lactiplantibacillus
plantarum
is
a
Gram-positive,
bacilli-shaped
bacterium
commonly
found
in
fermented
foods
and
the
human
gastrointestinal
tract.
Heat-treatment
of
L.
OLL2712
prior
to
consumption
has
been
have
positive
health
effects.
However,
full
toxicological
evaluation
heat-treated
cells
(heat-treated
OLL2712)
not
conducted.
In
this
regard,
was
evaluated
for
use
as
an
ingredient
food
dietary
supplements
using
panel
tests
including
genotoxic
subchronic
studies.
Heat-treated
did
show
any
genotoxicity
based
on
vitro
mammalian
chromosomal
aberration
test
vivo
mouse
micronucleus
assay
up
8.0
×
10
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8998 - 8998
Published: Aug. 19, 2024
Parkinson's
Disease
(PD)
is
a
prevalent
neurodegenerative
disorder
characterized
by
motor
and
non-motor
symptoms.
Emerging
evidence
suggests
that
gut
microbiota
alterations,
specifically
involving
short-chain
fatty
acids
(SCFAs)
like
butyrate,
may
influence
PD
pathogenesis
symptomatology.
This
Systematic
Review
aims
to
synthesize
current
research
on
the
role
of
butyrate
in
modulating
symptoms
its
neuroprotective
effects
PD,
providing
insights
into
potential
therapeutic
approaches.
A
systematic
literature
search
was
conducted
April
2024
across
databases,
including
ScienceDirect,
Scopus,
Wiley,
Web
Science,
for
studies
published
between
2000
2024.
Keywords
used
were
"neuroprotective
AND
(Parkinson
disease
OR
symptoms)".
Four
authors
independently
screened
titles,
abstracts,
full
texts,
applying
inclusion
criteria
focused
investigating
regulation
total
1377
articles
identified,
with
40
selected
full-text
review
14
meeting
criteria.
Data
extraction
performed
study
population,
models,
methodology,
intervention
details,
outcomes.
Quality
assessment
using
SYRCLE
RoB
tool
highlighted
variability
quality,
some
biases
noted
allocation
concealment
blinding.
Findings
indicate
has
significant
impact
improving
offers
benefits
models.
The
modulation
enhance
levels
presents
promising
strategy
symptom
management.
Fermentation,
Journal Year:
2024,
Volume and Issue:
10(7), P. 339 - 339
Published: June 28, 2024
Previously,
the
exopolysaccharides
produced
by
Lactiplantibacillus
plantarum
C7
isolated
from
broiler
intestine
have
been
shown
to
possess
probiotic
potential.
In
this
study,
we
highlighted
capacity
of
strain
produce
exopolysaccharide
(EPS)
endowed
with
several
biological
activities.
The
2,2-Diphenyl-1-picrylhydrazyl
(DPPH)
and
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic
acid)
(ABTS)
free
radical
scavenging
activities
EPS
were
found
be
30.4%
68.165%,
respectively,
at
100
mg/mL.
ferrous
reducing
potential
was
measured
25.26%.
Furthermore,
exhibited
antibacterial
effects
against
both
Gram-negative
Gram-positive
pathogens,
including
Escherichia
coli
ATCC
10536
Bacillus
cereus
11778,
inhibition
zones
22.5
±
0.70
mm
20
1.41,
respectively.
On
other
hand,
also
excellent
inhibitory
activity
butyrylcholinesterase
(BChE),
achieving
70.99%
a
concentration
10
FTIR
spectra
used
characterize
functional
groups
in
EPS.
Our
findings
proved
that
could
explored
for
various
applications,
particularly
health
food
sectors.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8564 - 8564
Published: Aug. 6, 2024
Probiotics
can
affect
human
health,
keep
the
balance
between
beneficial
and
pathogenic
bacteria,
their
colonizing
abilities
enable
enhancement
of
epithelial
barrier,
preventing
invasion
pathogens.
Health
benefits
probiotics
were
related
to
allergy,
depression,
eczema,
cancer,
obesity,
inflammatory
diseases,
viral
infections,
immune
regulation.
Probiotic
bacterial
cells
contain
various
proteins
that
function
as
effector
molecules,
explaining
roles
in
probiotic
actions
is
a
key
developing
efficient
targeted
treatments
for
disorders.
Systematic
proteomic
studies
(probioproteomics)
provide
information
about
type
involved,
expression
levels,
pathological
changes.
Advanced
methods
with
mass
spectrometry
instrumentation
bioinformatics
point
out
potential
candidates
next-generation
are
regulated
under
pharmaceutical
frameworks.
In
addition,
application
proteomics
other
omics
creates
powerful
tool
expand
our
understanding
diverse
functionality.
this
review,
strategies
identification/quantitation
bacteria
overviewed.
The
types
investigated
by
described,
such
intracellular
proteins,
surface
secreted
extracellular
vesicles.
Examples
conditions
which
played
crucial
discussed.
Journal of Applied Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Lactiplantibacillus
plantarum
is
a
Gram-positive,
bacilli-shaped
bacterium
commonly
found
in
fermented
foods
and
the
human
gastrointestinal
tract.
Heat-treatment
of
L.
OLL2712
prior
to
consumption
has
been
have
positive
health
effects.
However,
full
toxicological
evaluation
heat-treated
cells
(heat-treated
OLL2712)
not
conducted.
In
this
regard,
was
evaluated
for
use
as
an
ingredient
food
dietary
supplements
using
panel
tests
including
genotoxic
subchronic
studies.
Heat-treated
did
show
any
genotoxicity
based
on
vitro
mammalian
chromosomal
aberration
test
vivo
mouse
micronucleus
assay
up
8.0
×
10
