Metabolites,
Journal Year:
2024,
Volume and Issue:
14(10), P. 517 - 517
Published: Sept. 25, 2024
Background:
Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
autoimmune
disease.
The
fruits
of
Illicium
verum,
which
medicinal
and
edible
resource,
have
been
shown
to
anti-inflammatory
properties.
Methods:
In
this
study,
we
investigated
the
effects
I.
verum
extracts
(IVEs)
on
human
RA
fibroblasts-like
synoviocytes
(RA-FLS)
by
using
sensitive
selective
ultra-high-performance
liquid
chromatography
with
high-definition
mass
spectrometry
(UPLC-HDMS)
method.
We
subsequently
analyzed
metabolites
produced
after
incubation
cultured
RA-FLS
IVEs.
Results:
IVEs
inhibited
proliferation
suppressed
migration
RA-FLS,
reduced
levels
factors
including
TNF-α
IL-6.
Twenty
differential
responsible
for
were
screened
annotated
based
UPLC-HDMS
data
cell
metabolomics
approach.
Discussion:
Our
findings
suggest
that
treating
can
regulate
lipid
amino
acid
metabolism,
indicating
extract
has
potential
modify
metabolic
pathways
cause
inflammation
in
RA.
Conclusions:
This
might
lead
novel
therapeutic
strategies
managing
patients
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2389 - 2389
Published: Oct. 18, 2024
Osteoporosis
(OP)
is
a
prevalent
skeletal
disorder
characterized
by
decreased
bone
mineral
density
(BMD)
and
increased
fracture
risk.
The
advancements
in
omics
technologies—genomics,
transcriptomics,
proteomics,
metabolomics—have
provided
significant
insights
into
the
molecular
mechanisms
driving
OP.
These
technologies
offer
critical
perspectives
on
genetic
predispositions,
gene
expression
regulation,
protein
signatures,
metabolic
alterations,
enabling
identification
of
novel
biomarkers
for
diagnosis
therapeutic
targets.
This
review
underscores
potential
these
multi-omics
approaches
to
bridge
gap
between
basic
research
clinical
applications,
paving
way
precision
medicine
OP
management.
By
integrating
technologies,
researchers
can
contribute
improved
diagnostics,
preventative
strategies,
treatments
patients
suffering
from
related
conditions.
Expert Review of Anticancer Therapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 12, 2025
Bone
metastasis
often
develops
in
advanced
malignancies.
Lipid
metabolic
dysregulation
might
play
pivotal
role
cancer
progression
and
subsequent
deterioration
of
bone
health
at
metastatic
condition.
In-depth
understanding
lipid
reprogramming
metastasized
cells
other
stromal
including
marrow
adipocyte
(BMA)
is
an
urgent
need
to
develop
effective
therapy.
This
paper
emphasizes
providing
overview
multifaceted
dysregulated
lipids
BMA
association
with
by
utilizing
search
terms
metabolism,
PubMed.
study
extends
address
mechanism
linked
metabolism
various
crucial
genes
(e.g.
CSF-1,
RANKL,
NFkB
NFATc1)
involved
metastasis.
review
examines
therapeutic
strategies
targeting
offer
potential
avenues
disrupt
lipid-driven
On
condition,
molecules
especially
not
only
favors
but
also
potentiate
within
cells.
Distinct
lipid-metabolism
associated
may
act
as
biomarker,
these
challenging
task
for
specific
treatment.
Curbing
function
resorption
controlling
drugs
statins,
omega-3
FA
metformin)
provide
additional
support
curtail
lipid-associated
Current Osteoporosis Reports,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 23, 2025
This
review
summarizes
the
recently
published
scientific
evidence
regarding
role
of
enzymes
engaged
in
de
novo
anabolic
biosynthesis,
catabolic,
and
salvage
pathways
ceramide
bioactive
sphingolipids
bone
dynamics
skeletal
health.
Ceramides
are
precursors
for
sphingolipids,
including
sphingosine,
sphingosine-1-phosphate,
others.
Studies
metabolism
bone-related
cells
demonstrated
that
sphingosine-1-phosphate
control
levels
remodeling
resorption
generated
by
osteoblasts
osteoclasts.
Multiple
studies
critical
regulating
ceramide/sphingosine-1-phosphate
ratio
relative
to
physiology
promotion
inflammatory
osteolysis.
Accordingly,
emerging
suggests
targeting
sphingolipid
has
potential
alleviate
osteolysis
accelerate
regeneration.
Therefore,
this
study
aimed
discuss
current
knowledge
about
crosstalk
between
their
metabolic
within
osteoclast
osteoblast
coupling
pathogenic
highlights
complexity
biosynthesis
gaps
pathology.
We
also
importance
canonical
non-canonical
mammalian
bacterial-derived
Poultry Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 105270 - 105270
Published: May 1, 2025
In
laying
hens,
maintaining
optimal
bone
health
and
development
from
the
early
stages
is
crucial,
as
it
directly
affects
their
egg-laying
efficiency,
overall
welfare
productivity.
Studies
have
shown
that
grape
polyphenols
Vitis
vinifera
enhance
in
both
humans
animals.
Still,
mechanisms
behind
this
effect
remain
unclear,
given
diversity
of
varying
action.
The
objective
study
was
to
investigate
a
standardized
dry
extract
(SDGE)
on
quality
metabolome
future
hens
reared
commercial
conditions.
Therefore,
36300
day-old
pullets
were
randomly
divided
into
two
barns
same
farm
site.
Both
received
diet,
with
addition
30
mg/kg
SDGE
(Nor-Grape®,
Nor-Feed,
France)
day
1
until
week
17
supplemented
group
(SDGE).
At
end
supplementation
period,
several
parameters
analyzed
50
individuals
per
group.
Additionally,
non-targeted
metabolomics
plasma
bones
performed
uncover
impact
pullet's
metabolome.
Results
demonstrated
keel
deformity
tended
improve
following
(P
=
0.10).
Moreover,
intake
significantly
increased
mineral
content,
compared
control
<
0.05)
increase
calcium
(Ca)
0.074)
phosphorus
(P)
content
0.055).
On
other
hand,
samples
revealed
an
fatty
acids
glycerophospholipid
metabolisms
while
analysis
uncovered
pathways
related
sphingolipid
estrogen
mediated
signaling
pathways.
Overall,
suggests
novel
through
lipid
metabolism
highlights
nutritional
intervention
developmental
stage
improves
prior
entry
phase,
thus
proving
useful
tool
management.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 22, 2024
Immunometabolism
has
been
an
emerging
hotspot
in
the
fields
of
tumors,
obesity,
and
atherosclerosis
recent
decades,
yet
few
studies
have
investigated
its
connection
with
rheumatoid
arthritis
(RA).
In
principle,
intracellular
metabolic
pathways
upstream
regulated
by
nutrients
growth
factors
control
effector
functions
immune
cells.
Dynamic
communication
hypermetabolic
lesions
cells
within
inflammatory
synovial
microenvironment
contributes
to
development
progression
RA.
Hence,
targeting
subpopulations
pathological
may
represent
novel
therapeutic
strategies
for
Natural
products
constitute
a
great
potential
treasury
research
drugs
Here,
we
aimed
delineate
atlas
glycolysis,
lipid
metabolism,
amino
acid
biosynthesis,
nucleotide
metabolism
RA
that
affect
processes
Meanwhile,
potentials
pharmacological
mechanisms
natural
are
demonstrated
inhibit
related
key
enzymes
or
reverse
signals
were
discussed
highlighted.
Periodontal
disease
ranks
among
the
most
expensive
health
conditions
to
treat,
asreported
by
World
Health
Organization
(WHO).
This
is
due
fact
thatdiagnosis
based
on
several
specific
clinical
criteria
that
employ
methods
suchas
inspection,
palpation,
probing,
and
interpretation
of
radiographic
images.However,
since
these
diagnostic
tools
do
not
provide
information
about
patientsat
risk
developing
severe
stage
periodontal
disease,
patients
are
oftenovertreated.
Porphyromonas
gingivalis
a
prevalent
bacterium
in
thesubgingival
crevice
with
has
been
termed
akeystone
pathogen
conditions.
P.
together
its
enzymes,Rgp
Kgp,
therefore
interest
as
potential
biomarkers
which
builddiagnostic
artificial
receptors.
Firstly,
molecularly
imprintedpolymers
using
either
native
enzymes
or
short
sequence
epitopes
from
themcan
be
used
determine
expression
level
samples.Secondly,
enzymatic
activity
can
determined
recording
changes
inelectrochemical
signals
before
after
hydrolysis
specially
designedpeptide
selective
for
one
enzymes.
Finally,
reversible
selfassembledmonolayers
bearing
ligands
bacterial
adhesion
throughmultivalent
interactions
potentially
employed
selectively
separate
anddetect
gingivalis.
Together,
they
form
foundation
designing
acommercially
exploitable
biosensor
combines
detection
improvethe
accuracy
diagnosis.
Diseases,
Journal Year:
2024,
Volume and Issue:
12(9), P. 195 - 195
Published: Aug. 23, 2024
Abnormalities
in
lipid
homeostasis
have
been
associated
with
many
human
diseases,
and
the
interrelation
between
lipotoxicity
cellular
dysfunction
has
received
significant
attention
past
two
decades.
Ceramides
(Cers)
are
bioactive
molecules
that
serve
as
precursors
of
all
complex
sphingolipids.
Besides
their
function
structural
components
cell
mitochondrial
membranes,
Cers
play
a
role
key
mediators
metabolism
involved
numerous
processes,
such
proliferation,
differentiation,
inflammation,
induction
apoptosis.
The
accumulation
various
ceramides
tissues
causes
metabolic
disturbances.
Recent
studies
suggest
Cer
an
important
obesity,
syndrome,
type
2
diabetes,
atherosclerosis,
cardiovascular
diseases
(CVDs).
In
humans,
elevated
plasma
ceramide
levels
insulin
resistance
impaired
health.
this
review,
we
summarize
inflammation
potential
promising
diagnostic
tool.
