Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules DOI Creative Commons
Sosuke Yagishita,

Megumi Shibata,

Akiko Furuno

et al.

Neurology International, Journal Year: 2024, Volume and Issue: 16(3), P. 653 - 662

Published: June 11, 2024

The tau protein is a microtubule-associated that promotes microtubule stabilization. phosphorylation of the has been linked to its dissociation from microtubules. Here, we examined relationship between neuronal depolarization activity and by employing model systems in culture as well vivo. KCl-evoked cultured neurons often used investigate effects activity. We found dephosphorylation at AT8 sites (S202, T205), T212, AT180 (T231, S235), S396 KCl-simulated neurons. also KCl-induced increases level fractionated with stable In an vivo experiment, demonstrated exposure mice new environment activates phosphatase 1 mouse hippocampus induces dephosphorylation. increased amount fraction, suggesting may lead association These results suggest microtubules proteins be regulated status affected electrical

Language: Английский

Ginsenoside Rg1 improves autophagy dysfunction to ameliorate Alzheimer's disease via targeting FGR proto-oncogene DOI

Qiankun Quan,

Xinxin Ma, Jundong Feng

et al.

Neuropeptides, Journal Year: 2025, Volume and Issue: 111, P. 102514 - 102514

Published: March 4, 2025

Language: Английский

Citations

1
A Look at the Etiology of Alzheimer's Disease based on the Brain Ischemia Model DOI
Ryszard Pluta

Current Alzheimer Research, Journal Year: 2024, Volume and Issue: 21(3), P. 166 - 182

Published: March 1, 2024

Alzheimer's disease (AD) is the frequent form of dementia in world. Despite over 100 years research into causes AD, including amyloid and tau protein, has stalled not led to any conclusions. Moreover, numerous projects aimed at finding a cure for AD have also failed achieve breakthrough. Thus, failure anti-amyloid anti-tau protein therapy treat significantly influenced way we began think about etiology disease. This situation prompted group researchers focus on ischemic brain episodes, which, like mostly present alterations hippocampus. In this context, it been proposed that cerebral incidents may play major role promoting neurodegeneration AD. review, summarized experimental clinical conducted several episodes development Studies shown changes typical course post-ischemia, i.e., progressive hippocampal atrophy, increased production, modification protein. post-ischemic brain, diffuse senile plaques neurofibrillary tangles characteristic were revealed. The above data evidently showed after ischemia, there are modifications folding, leading massive neuronal death damage network, which triggers with phenotype.

Language: Английский

Citations

4
Tau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program DOI
Robson Campos Gutierre,

Pamela Russel Machado Rocha,

Alexandre Lebedev Graciani

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1850, P. 149419 - 149419

Published: Dec. 25, 2024

Language: Английский

Citations

1
Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules DOI Creative Commons
Sosuke Yagishita,

Megumi Shibata,

Akiko Furuno

et al.

Neurology International, Journal Year: 2024, Volume and Issue: 16(3), P. 653 - 662

Published: June 11, 2024

The tau protein is a microtubule-associated that promotes microtubule stabilization. phosphorylation of the has been linked to its dissociation from microtubules. Here, we examined relationship between neuronal depolarization activity and by employing model systems in culture as well vivo. KCl-evoked cultured neurons often used investigate effects activity. We found dephosphorylation at AT8 sites (S202, T205), T212, AT180 (T231, S235), S396 KCl-simulated neurons. also KCl-induced increases level fractionated with stable In an vivo experiment, demonstrated exposure mice new environment activates phosphatase 1 mouse hippocampus induces dephosphorylation. increased amount fraction, suggesting may lead association These results suggest microtubules proteins be regulated status affected electrical

Language: Английский

Citations

0